Water soluble transition metal [Ni(ii), Cu(ii) and Zn(ii)] complexes of N-phthaloylglycinate bis(1,2-diaminocyclohexane). DNA binding, pBR322 cleavage and cytotoxicity

Abstract

A series of water-soluble ionic complexes (1–3) were synthesized as potent anticancer agents.

Hydrazylpyridine salicylaldehyde–copper(ii)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation

“…The cytotoxic activity of Cugdupt1–Cugdupt9 was evaluated by the CCK-8 assays to assess IC 50 values (μM) 36,37 on A549 and A549cis cancer cells as well as HL-7702 normal cells. Cugdupt1–Cugdupt9 exhibited significantly greater potency for A549cis cells than A549 and HL-7702 cells with different toxicity from cisplatin (Table 2).…”

Ru(II)(ƞ6-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System

“…The change in electrophoretic mobility of pBR322 plasmid DNA on agarose gel provided further evidence for DNA-drug interactions [ 36 , 37 , 38 ]. The migration of pBR322 plasmid DNA from its supercoiled form (Form I) to its nicked (Form II) or linear form (Form III) after its interaction with drug candidates provides evidence for DNA-drug interactions [ 39 ].…”

Revelation of potential bioactive water-soluble Boc-l-valine and imidazole appended metal complexes {M = Co(ii), Cu(ii) & Zn(ii)}: synthesis, characterization, ct-DNA binding, pBR322 cleavage, SOD mimetic, and cytotoxicity studies

“…5,6 This has sparked interest in the development of novel DNA-targeted water-soluble drug candidates derived from 3d-transition metals viz., Co, Cu and Zn coordinated to N, O and S donor ligands exhibiting distinct anticancer potential with lower toxicity towards healthy cells. [7][8][9][10] Amino acids possess versatile coordination chemistry owing to their structural and stereochemical features. 11 Copper-based compounds of amino acids have shown better prospects as anticancer drugs, exhibiting good DNA scission propensity via the oxidative pathway, SOD mimetic, and antioxidants.…”

“…5,6 This has sparked interest in the development of novel DNA-targeted water-soluble drug candidates derived from 3d-transition metals viz ., Co, Cu and Zn coordinated to N, O and S donor ligands exhibiting distinct anticancer potential with lower toxicity towards healthy cells. 7–10…”