Hydrazylpyridine salicylaldehyde–copper(ii)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation

Abstract

We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes, [Cu(L1a)(phen)] (Cugdupt1), [Cu(L2a)(phen)]·(CH3CN) (Cugdupt2), [Cu(L3a)(phen)] (Cugdupt3), [Cu(L4a)(phen)]·(CH3CN) (Cugdupt4), [Cu(L5a)(phen)] (Cugdupt5), [Cu(L6a)(phen)] (Cugdupt6), [Cu(L7a)(phen)] (Cugdupt7) [Cu(L8a)(phen)] (Cugdupt8) and [Cu(L9a)(phen)]·0.5(H2O)...

Copper and Copper Complexes in Tumor Therapy

“…These agents suggested a promising potential for cisplatin-resistant tumor therapy. [98] GuoJin Huang et al synthesized a fluorescent dithiocarbazate À copper complexes, Cu II 2 Cu I (L) 2 (Br) 3 , which can significantly inhibits the growth of pancreatic cancer cells in vivo. Interestingly, the fluorescent properties of Cu II 2 Cu I (L) 2 (Br) 3 enables its ability to be used for in vivo imaging.…”

Fe(ii) complexes of 2,2′:6′,2′′-terpyridine ligands functionalized with substituted-phenyl groups: synthesis, crystal structures and anticancer potential

“…The terpyridine ligands (L [1][2][3][4][5][6][7][8][9] ) used in the present work were synthesized according to the literature, 64,65 including 4′phenyl-terpyridine(L 1 ), 4′-(4-methylsulfony-phenyl)-2,2′:6′,2″terpyridine(L 2 ), 4′-(4-carboxyl-phenyl)-2,2′:6′,2″-terpyridine(L 3 ), Fig. 12 CD spectra of complex 3 to BSA at different concentration ratios.…”

“…1,2 In recent years, the significant advantages of organometallic complexes in tumor therapy have been gradually recognized. [3][4][5][6][7][8][9] In particular, platinumbased organometallic complexes, such as cisplatin, carboplatin, oxaliplatin, etc., are widely used in the clinical treatment of cancer. Their successful application has aroused wide interest in designing and developing such antitumor analogues.…”

Synthesis, characterization, and cancer cell-selective cytotoxicity of mixed-ligand cobalt(iii) complexes of 8-hydroxyquinolines and phenanthroline bases

“…Metal complexes of 1,10-phenanthroline (phen) and its derivatives have been extensively explored as anticancer agents. 31,32 Two well-studied phenanthroline derivatives, dipyrido[3,2- d :2′,3′- f ]quinoxaline (dpq) and dipyrido[3,2- a :2′,3′- c ]phenazine (dppz), serve as neutral N,N-donor bidentate ligands with a strong affinity for transition metal ions, including cobalt( iii ). Due to their aromaticity and extended planarity, these ligands can avidly bind to DNA and function as anticancer agents when coordinated to a metal ion.…”