Revelation of potential bioactive water-soluble Boc-l-valine and imidazole appended metal complexes {M = Co(ii), Cu(ii) & Zn(ii)}: synthesis, characterization, ct-DNA binding, pBR322 cleavage, SOD mimetic, and cytotoxicity studies

Abstract

Bio-compatible water-soluble conjugates of Co(II), Cu(II) and Zn(II) (1-3), [Co(Boc-L-Valine)2(Imidazole)2], [Cu(Boc-L-Valine)2(Imidazole)2] and [Zn(Boc-L-Valine)2(Imidazole)2], were synthesized and comprehensively characterized by various spectroscopic techniques {UV–visible, FT-IR, ESI-MS, EPR, 1H NMR, 13C NMR}...

Repurposing the antihistamine drug bilastine as an anti-cancer metallic drug entity: synthesis and single-crystal X-ray structure analysis of metal-based bilastine and phen [Co(ii), Cu(ii) and Zn(ii)] tailored anticancer chemotherapeutic agents against resistant cancer cells

“…The EPR spectrum of complex 2 exhibited an isotropic signal with g ‖ = 2.126 and g ⊥ = 2.073. Complex 2 followed the trend g ‖ > g ⊥ > 2.0023, indicating that the Cu( ii ) complex has a d x 2 − y 2 ground state with a tetragonally extended octahedron geometry around the metal centre with d 9 configuration 24 (Fig. S3†).…”

Facile Generation of tert-Butoxycarbonyl Chloride Equivalent and Its Use in Microflow Reactor

“…Organic compounds containing a tert -butoxycarbonyl (Boc) group serve as biologically active molecules and functional materials . The Boc group plays a crucial role as a protecting group for alcohols and amines; in particular, it is highly significant as a protective group for amines because tert -butyl carbamates are sufficiently stable under a wide range of conditions, and the Boc group can be readily removed under mild acidic conditions .…”