Water‐soluble omega‐3: A concept for purification of fish oil and nutraceuticals?

Abstract

There is a need for improved processes for preparation of omega-3 PUFA formulations having a high content of PUFA, low levels of persistent environmental pollutants (EPs), acceptable oxidation stability and if possible, can be formulated as a powder. Using N-methyl glucamine (meglumine), which forms water-soluble omega-3 salts, an extraction process was developed that for the first time removed the EPs present in the starting material (commercially available cod liver oil added fish oil, CLO-FO). GC/high-resolution MS (GC-HRMS) showed levels of three common EPs that were below LOQ. Further, the fatty acid salts isolated were enriched in omega-3 and appeared as watersoluble white powders. The overall process increased the content of omega-3 by >70% compared with CLO-FO. The content of saturated fatty acids was reduced from 12.8 AE 0.6 to 2.1 AE 0.1%. In spite of using inert conditions during preparation, the oxidative deterioration was significant. When this issue is resolved, the powder may be further developed for use in tablets or other nutritional and health products.

Enrichment process for α‐linolenic acid from silkworm pupae oil

“…There was a significant difference between the recoveries of ALA, LA, and OA from the FFAs extracted from the desilked silkworm pupae oil, which indicates that the β‐CD inclusion exhibited a selective enrichment ability for the purification of three PUFAs. Because β‐CD consists of crystalline, nonhygroscopic, cyclic oligosaccharides with a relatively lipophilic interior and a hydrophilic exterior, the role of β‐CD may be to form inclusion complexes with the PUFA tails within the internal cavity of the β‐CD molecular .…”

Formulating functional foods with long‐chain polyunsaturated fatty acids: Challenges and opportunities

“…In the present issue of EJLST, Borhaug and coworkers proposed a process to prepare water soluble n-3 LC-PUFA concentrate from cod-liver oil [17]. Water soluble n-3 LC-PUFA ingredients are not commercially available and therefore the aim of the study published by Borhaug and coworkers is per se very innovative.…”