There is a need for improved processes for preparation of omega-3 PUFA formulations having a high content of PUFA, low levels of persistent environmental pollutants (EPs), acceptable oxidation stability and if possible, can be formulated as a powder. Using N-methyl glucamine (meglumine), which forms water-soluble omega-3 salts, an extraction process was developed that for the first time removed the EPs present in the starting material (commercially available cod liver oil added fish oil, CLO-FO). GC/high-resolution MS (GC-HRMS) showed levels of three common EPs that were below LOQ. Further, the fatty acid salts isolated were enriched in omega-3 and appeared as watersoluble white powders. The overall process increased the content of omega-3 by >70% compared with CLO-FO. The content of saturated fatty acids was reduced from 12.8 AE 0.6 to 2.1 AE 0.1%. In spite of using inert conditions during preparation, the oxidative deterioration was significant. When this issue is resolved, the powder may be further developed for use in tablets or other nutritional and health products.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.