Water‐soluble cationic polymers and their polymer–metal complexes with biocidal activity: A genotoxicity study

Abstract

Water-soluble polyelectrolytes containing ammonium and sulfonic groups, their polymer-Ag(I) complexes, and silver nitrate were investigated as bactericidal compounds for Staphylococcus aureus (Collection No. ATCC 28922) and Escherichia coli (Collection No. 6538P) according to the National Committee for Clinical Laboratory Standards (NCCL) method. All the compounds, except Ag(I), showed bactericidal activity only for S. aureus. Ag(I) showed high bactericidal activity for both bacteria. No important effect of the molecular weight or macromolecular size on the maximum bactericidal concentration value was observed. The genotoxicity was studied using the rec assay. None of the macromolecular compounds showed genotoxicity, except silver ions, whose value was borderline. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: [452][453][454][455][456][457] 2003

Online Multi-Stage Membrane Filtration of Synthetic Polydispersed Water-Soluble Polymers With Uv Visible Absorption as a Mode for Their Detection

“…245, 230, and 220 nm in the interval 0.1 -4.0 mg/mL, 0.2 -3.0 mg/mL and 0.2 -6.0 mg/mL for samples 1, 2, and 3 respectively. The equations of calibration graphs and regression coefficients (R) for sample number 1, 2, and 3 are: [8][9][10]. We use the combination of MF and GPC to provide more complete information about the molecular weight distribution of the obtained fractions.…”

“…To better understand the mechanism of these reactions and thus be able to predict the polymer behavior, more detailed information is needed about molecules, structural constituents, molecular size, and degree of polymerization. The better characterization of polydispersed substances, which are complex mixtures of polymers and other products that are sometimes obtained after synthesis, can hardly be achieved without the application of fractionation techniques based on different properties of macromolecules, and especially their size [9,10].…”

Simple oligomers as antimicrobial peptide mimics

“…The cationic nature of the molecule is stressed due to the electrostatic interaction of the positive charges with the negatively charged species present in the cytoplasmic membrane [24]. Polymers often have an advantage over conventional small molecule antibacterial agents since they are essentially non-volatile and chemically stable [24]. Many of these compounds synthesized to date do not show selectivity towards bacteria over mammalian cells, rather they are biocidal.…”

“…In the latter topic, cationic polymers have been the focus [12,30,32] including those containing ammonium [9,14,25] or phosphonium salts [20], polylysine [10], pyridinium salts [28,34], or polyguanidines and polybiguanidines [1]. The cationic nature of the molecule is stressed due to the electrostatic interaction of the positive charges with the negatively charged species present in the cytoplasmic membrane [24]. Polymers often have an advantage over conventional small molecule antibacterial agents since they are essentially non-volatile and chemically stable [24].…”

Voltammetric investigation of polyelectrolyte-Cu(II) complexes

“…The formation of polyelectrolyte complexes therefore has been widely investigated over the last decades. Furthermore, polymer-metal complexes have been tested in various technological areas such as the recovery of metal ions from industrial fluids and waste water along with their biological importance [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”