Water dispersible CoFe2O4 nanoparticles with improved colloidal stability for biomedical applications

Abstract

Single phase cobalt ferrite (CoFe2O4, CFO) nanoparticles of a controlled size (~ 6 nm) exhibiting superparamagnetic properties have been synthesized by hydrothermal technique using oleic acid (OA) as surfactant. The oleic acid coated CFO nanoparticles are stable in nonpolar organic media, such as hexane but are not well dispersible in water. The surface of these snanoparticles has been further modified by citric acid using ligand exchange process, which makes CFO nanoparticles more stable colloidal solution in water. Citric acid coated CFO nanoparticles exhibits high dispersibility in water, high zeta potential, very low coercivity and moderate saturation magnetization. Biocompatibility of these CFO nanoparticles is demonstrated through cytotoxicity test in L929 cell line.

Mesoporous Cobalt Ferrite Nanosystems Obtained by Surfactant-Assisted Hydrothermal Method: Tuning Morpho-structural and Magnetic Properties via pH-Variation

“…Various preparation methods have been used in order to obtain cobalt ferrite NPs involving co-precipitation [12], thermal decomposition of metal salts in solvents with high boiling temperature [13], sol-gel [14], microemulsions [15], polyols [16], hydrothermal methods [17], combustion [18], sonochemistry [19], and electrochemical methods [20]. Particularly, mesoporous cobalt ferrite structures are very promising as recyclable anti-polluting agents [21], magnetically separable catalysts [22], and targeted drug delivery vehicles [23].…”

Synthesis and Properties of Nanosized Stoichiometric Cobalt Ferrite Spinel

“…Due to its magnetic properties, CoFe 2 O 4 nanoparticles may be employed in catalysts [1,2], cathode electrocatalyst of microbial fuel cells [3], or in various functional composite materials [4,5], including advanced adsorbents, for the removal of anionic pollutants from water [6]. Cobalt ferrite has been also considered as a good candidate for biomedical applications [7,8,9], especially for hyperthermia treatment, because of its high magneto-crystalline anisotropy [7]. …”

“…A usual synthetic technique for preparation of magnetic CoFe 2 O 4 nanoparticles is the co-precipitation method [1,2,3,4,5,6,7,8,9,10,11,12,13], but also hydrothermal [14,15,16,17], sol-gel auto-combustion [18,19], and microwave assisted [20,21] methods can be applied.…”

Processing and size range separation of pristine and magnetic poly( l -lactic acid) based microspheres for biomedical applications

“…These applications are based on the large surface area of the nanoparticles, good tissue diffusion and reduced dipole-dipole interaction [8]. When combined with the piezoelectric effect, magnetostrictive nanoparticles offer the possibility of developing magnetoelectric composites [9] that convert magnetic stimuli into electrical ones, leading to novel tissue engineering strategies [6,10].…”

“…In particular, cobalt ferrite magnetic particles have been explored for biomedical applications due to its large magnetostriction, high Curie temperature and effective anisotropy and moderate saturation magnetization, which can be taken to advantage both for tissue engineering and drug delivery applications [11]. However, they should be coated with organic or inorganic materials in order to ensure their biocompatibility, nontoxicity and colloidal stability [8].…”