Walker 256/B malignant breast cancer cells disrupt osteoclast cytomorphometry and activity in rats: Modulation by α-tocopherol acetate

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

“…Together, these phytochemical compounds might have better pharmacological properties than when separated. In fact, it has been reported that the whole-plant effects are usually much better than its active phytochemical compounds [ 13 ]. This might be the result of synergistic effects.…”

“…Earlier reports, including our studies, indicate that these cancerous cells, with high bone trophicity, induce bone loss, disrupt osteoclasts (the bone-resorbing cells) cyto-morphometry and enhance angiogenesis in vicinity of the bone metastatic foci [ 9 , 10 , 11 ]. The two used cell lines are poorly immunogenic and commonly used for murine models of bone osteolytic and osteosclerotic metastasis, respectively [ 5 , 12 , 13 ].…”

Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

“…Although the radical scavenging activities of the complex were lower than the standards, (2-HAMP) 2 [CoBr 4 ] exhibits good antioxidant activity once compared with BHT and Vit C. These results confirmed previous studies regarding antioxidant potentials of chemical compounds. [26,36,37] Several studies highlighted the importance of antioxidants against several pathologies, genotoxicity and cancer. [25,26,37,38] The anticancer effects of (2-HAMP) 2 [CoBr 4 ] were studied using two malignant cell lineages with high metastatic potential.…”

“…[26,36,37] Several studies highlighted the importance of antioxidants against several pathologies, genotoxicity and cancer. [25,26,37,38] The anticancer effects of (2-HAMP) 2 [CoBr 4 ] were studied using two malignant cell lineages with high metastatic potential. Figure 8 exhibits a dose-dependent effect on both MatÀ LyÀ Lu and Walker 256/B cancer cells.…”

“…The malignant cells have a high osteolytic potential, induced osteosclerotic and osteolytic tumor lesions. [4,25,26] The cells were grown in suspension in DMEM medium, which was supplemented with 5 % fetal calf serum, 1 % of non-essential amino acids complexed with penicillin (100 UI/mL), streptomycin sulphate (100 g/mL) and sodium pyruvate (1 mM). Both malignant Walker 256/B and MatÀ LyÀ Lu were seeded on 96-well plates (5 × 10 2 cells/well) with and without the synthesized compound.…”