Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α–Tocopherol Acetate Supplementation

Badraoui, Riadh; Bouali, Nouha; Hamadou, Walid Sabri; Elkahoui, Salem; Alam, Md. Jahoor; Siddiqui, Arif Jamal; Adnan, Mohd; Saoudi, Mongi; Rebaï, Tarek

doi:10.1007/s00223-021-00931-3

Cited by 27 publications

(51 citation statements)

References 66 publications

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“…2, possessed acceptable lipophilicity, as Log P o/w varied between 1.93 and 5.36. Previous reports indicated that Log P o/w < 5 is usually associated with good lipophilicity [ 5 , 21 , 22 , 33 ]. Their bioavailability scores prove their potential biological activities and the possibility of oral administration.…”

Section: Discussionmentioning

confidence: 99%

“…1, 9 and 12 were categorized as blood-brain-barrier (BBB) permeant. The majority of T. polium identified compounds were predicted not to be a substrate of P-glycoprotein (P-gp), which indicates the absence of significant disruption of drug transport [ 21 , 22 ]. Compounds No.…”

Section: Discussionmentioning

confidence: 99%

“…2, 4, 6, 10 and 11 inhibited none of the targeted CYP isoforms CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. None of the remaining compounds was predicted to be a potent inhibitor of the CYP studied isoforms, thus, indicating the lack of disrupted metabolism and excretion [ 21 , 23 ]. Log Kp varied between –0.55 and –9.94, which indicated moderate to low skin permeability.…”

Section: Discussionmentioning

confidence: 99%

“…4, Accession number: 668079) were obtained from the RCSB PDB and pubchem ® , respectively. Both ligand and receptors were processed for minimization and saved in pdbqt format as previously described [ 21 , 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

“…The binding assessment used in molecular docking and calculation of the binding energy was based on the CHARMm force field using MGL tools and Vina ® software (version 4.2.6) as previously described [ 3 , 21 , 24 ]. The ability of the ligands (major component of T. polium : selinidin) to bind to androgen receptors CYP-LBD and STING-LBD was studied after the removal of heteroatoms (warfarin) and water molecules and adding Coleman charges.…”

Section: Methodsmentioning

confidence: 99%

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Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

Rahmouni

Badraoui

Ben-Nasr

et al. 2022

Life

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This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium) and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of the extract were examined. The in vivo protective study was based on the use of an animal model of CCl4-induced liver cirrhosis. Four groups of rats have been used: Group I: control rats; Group II: received CCl4 in olive oil (0.5 mL/kg); Group III: received the EA T. polium (25 mg/kg) of pretreatment for seven days by gavage then CCl4 in olive oil by gavage for 15 days. Group IV: received the EA of T. polium for seven days (25 mg/kg). EA T. polium was found to possess significant antioxidant capacity. CCl4 caused a hepatotoxicity associated increase in both levels of AST and ALT, which were reduced back to normal values following EA T. polium pretreatment. Hepatotoxicity associated structural modifications of liver tissues and increase in thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and carbonyl proteins (CP), associated decreases in several assessed antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). The in vivo findings on the protective effect of T. polium were supported by its druggability, its pharmacokinetic properties and molecular docking assays. These results confirm the modulatory antioxidant and hepatoprotective potential of T. polium in this experimental liver cirrhosis model. T. polium phytochemicals are good candidates for further pharmaceutical explorations and drug design.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

Rahmouni

Badraoui

Ben-Nasr

et al. 2022

Life

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Comprehensive analysis of Seriphidium kurramense: GC/MS profiling, antibacterial and antibiofilm activities, molecular docking study and in-silico ADME profiling

Khatoon,

Alam,

Hussain

et al. 2024

Discov Appl Sci

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The emergence of drug-resistant bacteria poses a substantial threat to global healthcare, necessitating the development of novel therapeutic approaches. Seriphidium kurramense, a well-known aromatic, medicinal, and culinary herb, has garnered attention due to its potential medicinal properties. In this study, we investigated the chemical composition, antibacterial, and antibiofilm activities of Seriphidium kurramense plant extract. The coupled analysis of GC/MS (Gas chromatography/ mass spectrometry) has identified seventeen components in the extract, with major constituents including α-santonin (42.2%), eucalyptol (3.04%), and bicyclo[3.1.0]hexan-3-one (10.1%). The research encompassed four bacterial strains (E. coli, Bacillus, Staphylococcus aureus, and Salmonella), all involved in biofilm formation. The results indicated that the plant extract exhibited varying efficacy against the tested bacterial strains. Additionally, the ADME profiling of the identified phytocompounds supported their potential as drug candidates with promising pharmacokinetic properties. In-silico molecular docking studies revealed that among the 17 identified phytocompounds, lumisantonin displayed the highest effectiveness as an antibiofilm and antibacterial agent. It was closely followed by n-Hexadecanoic acid, ß-Copaene, and other compounds examined in the docking studies. These compounds exhibited high binding scores with target proteins, suggesting their potential as therapeutic agents. This comprehensive investigation not only sheds light on the chemical composition and pharmacological properties of Seriphidium kurramense compound but also presents a promising avenue for developing innovative drugs against drug-resistant bacterial strains. The results of this investigation provide valuable insights to the ongoing efforts in addressing the pressing issue of drug-resistant bacteria in global healthcare.

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Ecotoxicity of chrysene and phenanthrene on meiobenthic nematodes with a case study of Terschellingia longicaudata: Taxonomics, toxicokinetics, and molecular interactions modelling

Badraoui

Allouche

Ouaer

et al. 2023

Environmental Pollution

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Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α–Tocopherol Acetate Supplementation

Cited by 27 publications

References 66 publications

Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

Comprehensive analysis of Seriphidium kurramense: GC/MS profiling, antibacterial and antibiofilm activities, molecular docking study and in-silico ADME profiling

Ecotoxicity of chrysene and phenanthrene on meiobenthic nematodes with a case study of Terschellingia longicaudata: Taxonomics, toxicokinetics, and molecular interactions modelling

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