Waist hip ratio: an anatomical predictive marker of risk of PCOS

Yadav, Sumitra; Tarware, Ritu

doi:10.18203/2320-1770.ijrcog20191231

Cited by 11 publications

(10 citation statements)

References 8 publications

(8 reference statements)

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“…Conversely, no significant correlations were noted between vitamin D levels and age, BMI, reproductive hormones (progesterone, testosterone, estradiol, prolactin, AMH, TSH, FSH, LH, LH/FSH ratio), lipid profile (TC, HDL-C, LDL-C, TG, VLDL-C, LDL-HDL ratio), or insulin levels in either group (Table 3). group is in line with the clinical features typical of PCOS [2] and agrees with a previous report by Yadav and Tarware [16].…”

Section: Resultssupporting

confidence: 93%

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Akinola,

Inyangudo,

Ottun

et al. 2024

Cureus

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BackgroundPolycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by dyslipidemia, hormonal imbalances, and metabolic dysfunctions. Vitamin D deficiency may be implicated in the pathogenesis of PCOS, potentially exacerbating its metabolic syndrome. However, the exact interplay between these factors remains underexplored. AimThis study aimed to evaluate serum levels of vitamin D and its association with modalities of PCOS among women with PCOS and healthy controls. MethodsThis was a hospital-based case-control study where 60 women newly diagnosed with PCOS and 56 non-PCOS controls were consecutively recruited within a 10-month period. The women aged 20-40 were recruited at the gynecology clinics of Lagos State University Teaching Hospital and Lagos Island Maternity Hospital. PCOS was diagnosed using the Rotterdam's criteria. The biodata, anthropometry, clinical features, serum vitamin D, cortisol, progesterone, testosterone, estradiol, prolactin, anti-Mullerian hormone (AMH), thyroid-stimulating hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), insulin, fasting blood glucose (FBG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and very-low-density lipoprotein cholesterol (VLDL-C) levels of PCOS-diagnosed women were assessed and compared with those of women without PCOS. The exclusion criteria comprised known diabetics, women with gynecological pathologies such as fibroids, and women on medications affecting the study analytes or hormones. Statistical analyses included chi-square or Fisher's exact tests for categorical variables, student t-test for continuous variables, and Pearson's correlation for assessing relationships between continuous variables. The significance level was set at p<0.05 and a confidence interval of 95%. ResultsIndividuals with PCOS exhibited a younger mean age (26.90±3.73 versus 29.95±5.00 years, p=0.001) and a higher prevalence of irregular menstrual patterns (46.7% versus 14.3%, p=0.0001) and acne (58.3% versus 37.5%, p=0.025). Moreover, PCOS was associated with elevated levels of TC (p = 0.03), TG (p = 0.03), LDL-C (p = 0.014), FBG (p = 0.001), LH:FSH ratio (p = 0.002), AMH (p = 0.0001), and testosterone (p = 0.003), but low progesterone (p = 0.001) and vitamin D (p = 0.033), alongside a higher incidence of vitamin D deficiency (33.3% versus 26.1%) and insufficiency (66.7% versus 56.5%). Additionally, significant but weak correlations were observed between serum vitamin D levels and waist-hip ratio (r = 0.4, p = 0.016) and FBG (r = -0.4, p = 0.036) in the PCOS group, suggesting potential metabolic implications. ConclusionThe PCOS subjects in this study had decreased vitamin D and progesterone levels, with elevated concentrations of testosterone, AMH, lipid profile (TC, LDL, and TG), FBG, and LH:FSH ratio. Studies on the therapeutic effect of vitamin D administration in managing PCOS will need to be further evaluated.

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Section: Resultssupporting

confidence: 93%

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Akinola,

Inyangudo,

Ottun

et al. 2024

Cureus

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“…Yadav et al in their study reported the mean waist-hip ratio as 0.87±0.05 which was close to our study. 13 Interestingly, the association of PCOS and the waist hip ratio reached statistical significance in the study by Yadav et al unlike our study wherein statistical significance was not reached. This could be explained by the difference in total number of cases which was 60 in this study versus 400 in their study.…”

Section: Table 3: Distribution Of Subjects Based On Acnecontrasting

confidence: 80%

“…The mean age in this study for PCOS women was 22±3.9 years which was very close to the mean age of 23.26±3.56 years reported by Yadav et al in 2019. 13 However, earlier in 2017, Kumar et al in their study found the mean age of PCOS cases to be 28.6±6.3 years while Gul et al in 2018, found the mean age to be 26.7±7.54 years, higher than the mean age of this study. 14,15 This difference could be due to multiple factors explained as follows:…”

Section: Table 3: Distribution Of Subjects Based On Acnecontrasting

confidence: 62%

“…In 2019, Yadav et al also found a similar trend and their results also reached statistical significance. 13 In our study 20% of the PCOS cases had acne in contrast to 3.3% in the control group or expressed another way, acne was seen about 6 times more in PCOS subjects as compared to the control group. This was statistically significant with p value 0.0443 (Table 3).…”

Section: Table 3: Distribution Of Subjects Based On Acnecontrasting

confidence: 45%

“…Similarly, Yadav et al found acne in 32% of the PCOS subjects higher than our results. 13 Thus, acne is an important clinical sign for PCOS.…”

Section: Table 3: Distribution Of Subjects Based On Acnementioning

confidence: 99%

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Serum 25-OH vitamin D and insulin resistance in women with polycystic ovary syndrome

Chandra

Ansari²

2023

Int J Reprod Contracept Obstet Gynecol

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Background: This was a prospective case control study conducted in the department of obstetrics and gynecology, Era’s Lucknow Medical College and Hospital from November 2018 to March 2020. Aim was to find whether there was a link between serum 25-OH vitamin D levels, and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: 30 newly diagnosed cases of PCOS and 30 women without PCOS were enrolled. Their clinical details as well as BMI and waist hip ratio were noted. The biochemical parameters which were measured included fasting glucose, fasting insulin, serum 25-OH vitamin D. The insulin resistance was calculated. Results: 50% of the PCOS had insulin resistance and also deficient /or insufficient vitamin D levels, versus 16.7% in the control group. This association was statistically highly significant with p value as 0.00016. No statistical significance was found with regard to the mean serum 25-OH vitamin D level. 53.4%, of the PCOS women had hirsutism versus 3.3% in the control group and was statistically significant, p value <0.0001. 20% of PCOS women had acne in contrast to 3.3% in the control group which was statistically significant with p value 0.0443. Conclusions: Hirsutism and acne were important clinical signs of PCOS. There was a negative correlation between insulin resistance and serum 25-OH vitamin D levels. Thus, vitamin D may be an important link in the genesis of PCOS. Larger randomised case control studies need to be done to understand PCOS.

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Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India

Kaur

Sudhir

et al. 2021

Reprod. Sci.

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Waist hip ratio: an anatomical predictive marker of risk of PCOS

Cited by 11 publications

References 8 publications

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Exploring Serum Vitamin D, Sex Hormones, and Lipid Profile Disparities in Women With and Without Polycystic Ovarian Syndrome: A Case-Control Study

Serum 25-OH vitamin D and insulin resistance in women with polycystic ovary syndrome

Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India

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