Vulvar lichen sclerosus: A new regenerative approach through fat grafting

Boero, Veronica; Brambilla, Massimiliano; Sipio, Elisa; Liverani, Carlo Antonio; Martino, Mirella Di; Agnoli, Benedetta; Libutti, Giada; Cribiù, Fulvia Milena; Gobbo, Alessandro Del; Ragni, Enrico; Bolis, Giorgio

doi:10.1016/j.ygyno.2015.10.014

Cited by 43 publications

(47 citation statements)

References 31 publications

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“… 44 , 45 As with measurement of symptoms, there were also those who measured signs within qualitative categories of mild, moderate, and severe or early-, mid-, and end-stage disease, with some providing definitions of two of these labels (early and end stage, 46 and moderate, and severe 47 ), and others not defining these labels at all. 48 Some studies combined symptomatic complaint scores with clinical signs scores. 41 , 42 …”

Section: Resultsmentioning

confidence: 99%

“…Less commonly used measures of disease severity included the description of histological features such as epidermal atrophy, hyperkeratosis, and dermal inflammation 14 , 25 , 48 – 53 and the measurement of various inflammatory marks with immunohistochemical staining. 14 , 20 , 21 , 26 , 46 , 48 , 51 , 54 – 58 Finally, some studies focused on the quality-of-life effects of this disease as well as interference with sexual functioning. 18 , 22 , 35 , 48 , 59 , 60 …”

Section: Resultsmentioning

confidence: 99%

“… 14 , 20 , 21 , 26 , 46 , 48 , 51 , 54 – 58 Finally, some studies focused on the quality-of-life effects of this disease as well as interference with sexual functioning. 18 , 22 , 35 , 48 , 59 , 60 …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Sheinis

Selk

2018

J Low Genit Tract Dis

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Sheinis

Selk

2018

J Low Genit Tract Dis

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“…1 The etiology of LS is uncertain although there is evidence for linkages between autoimmune mechanisms and the pathogenesis of LS. 5 …”

mentioning

confidence: 99%

“…5,17 However, it still remains unclear whether PRP is a sufficiently effective treatment to replace topical steroids. The aim of this article is to present a new regenerative approach that removes symptoms and reduces atrophy and sclerosus in patients diagnosed with LS.…”

mentioning

confidence: 99%

Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus

Behnia-Willison

Pour

Mohamadi

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Background:Lichen sclerosus (LS) is an inflammatory dermatosis with autoimmune pathogenesis. Although relatively common, its true incidence is unknown and likely underestimated. LS is usually anogenital, but in around 10% of patients, it can present as extragenital lesions. Continuous administration of topical corticosteroids is the mainstay of medical treatment. Other treatments are available but are only occasionally prescribed along with or instead of topical steroids. Injection of platelet-rich plasma (PRP) into affected areas has been reported to result in the regeneration of normal skin. In this study, we aimed to evaluate the safety, symptom resolution, and objective improvement in patients with autoimmune condition like genital LS after treatment with PRP.Methods:Over a 2-year period at FBW Gynaecology Plus, we had a total of 28 patients with confirmed LS on biopsy, unresponsive to topical steroid treatment. After acquiring informed consent, patients’ own blood was centrifuged on site and injected under local anesthesia to the external genitalia.Results:Almost all of our patients showed clinical improvement in the size of their lesions, and in 8 cases, lesions totally disappeared after treatment with PRP. Symptoms disappeared in 15 of the 28 patients after treatment, with no need for further steroid therapy in 23 patients. Thirteen women experienced partial symptom relief.Conclusions:Based on our limited findings, we hypothesize that PRP presents a potential alternative to topical steroids for treatment of vulvovaginal autoimmune conditions such as LS. A larger pilot and/or randomized controlled trial study is required to evaluate this finding further.

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Cancer of the vulva: 2021 update

Olawaiye

Cuello

Rogers

2021

Intl J Gynecology & Obste

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Vulvar cancer is an uncommon gynecological malignancy primarily affecting postmenopausal women. There is no specific screening and the most effective strategy to reduce vulvar cancer incidence is the opportune treatment of predisposing and preneoplastic lesions associated with its development. While vulvar cancer may be asymptomatic, most women present with vulvar pruritus or pain, or have noticed a lump or ulcer. Therefore, any suspicious vulvar lesion should be biopsied to exclude invasion. Once established, the most common subtype is squamous cell carcinoma. Treatment of vulvar cancer depends primarily on histology and surgical staging. Treatment is predominantly surgical, particularly for squamous cell carcinoma, although concurrent chemoradiation is an effective alternative, particularly for advanced tumors. Management should be individualized and carried out by a multidisciplinary team in a cancer center experienced in the treatment of these tumors.

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Vulvar lichen sclerosus: A new regenerative approach through fat grafting

Cited by 43 publications

References 31 publications

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Development of the Adult Vulvar Lichen Sclerosus Severity Scale—A Delphi Consensus Exercise for Item Generation

Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus

Cancer of the vulva: 2021 update

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