Voxel based morphometric and diffusion tensor imaging analysis in male bipolar patients with first-episode mania

Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

“…Additionally, we found larger caudate nuclei in those with BD Type I, which is consistent with Ong et al (2012) who reported larger manually segmented caudates in those with BD Type I and particularly in those with a history of psychosis which the authors propose reflect alterations in specific frontostriatal circuitry in BD Type I. Furthermore, Chen et al (2012) found enlarged bilateral putamen in bipolar patients Table 2 Significant clusters detected in the right and left hemispheres between controls and BD subjects after multiple-corrections using raw and TBV normalized data. Note: BD¼ Bipolar disorder; Hem ¼ Hemisphere; L ¼Left; R¼ Right; Raw¼ Raw volumes; TBV ¼ Controlling for TBV; V ¼ Volume; Th ¼Thickness; Max ¼maximum À log 10(p value) in the cluster, VtxMax ¼ vertex number at the maximum, Size(mm2) ¼surface area (mm2) of cluster, TalX ¼Talairach (MNI305) coordinate of the maximum for x direction, TalY ¼Talairach (MNI305) coordinate of the maximum for y direction, TalZ ¼ Talairach (MNI305) coordinate of the maximum for z direction, CWP ¼p-value of the cluster, CWPLow¼lower 90% confidence interval CWPHi ¼ higher 90% confidence interval for CWP, Annotation¼ annotation of segmented region as defined by Freesurfer.…”

Combined analyses of gray matter voxel-based morphometry and white matter tract-based spatial statistics in pediatric bipolar mania

“…patients and reported GM changes in the ALN, including the right anterior insula, head of the caudate nucleus, the nucleus accumbens, the ventral putamen, the OFC and fiber tract coherence in the corpus callosum . Another study recruited male BD patients with first-episode mania only and found that BD patients had larger GM volume in the left thalamus and bilateral basal ganglia as well as reduced FA value of WM in the left posterior corona radiata (Chen et al, 2012). Those results were quite different from our findings and the differences might be associated with different neurobiology for pediatric and adult BD patients, the methodological differences (such as the use of VBA and TBSS), and the small sample sizes in our study.…”

“…Most MRI studies for PBD reported a trend toward a reduction in hippocampal volume (Bearden et al, 2008a;Frazier et al, 2005a), while no difference of hippocampal volume was also observed when comparing with healthy children (Chang et al, 2005). Studies on alterations of thalamus volume also reflected heterogeneous results, showing normal (Chang et al, 2005;Karchemskiy et al, 2011;Scherk et al, 2008), or enlarged volume (Adler et al, 2007;Chen et al, 2012;Wilke et al, 2004) in this region.…”

Widespread white matter tract aberrations in youth with familial risk for bipolar disorder

“…However, an ROI approach is limited in that it only allows for analyses of pre-defined a priori regions. Whole brain DTI analyses using standard voxel-based morphometry (VBM) in adults (Haznedar et al, 2005; Bruno et al, 2008; Wang et al, 2008a, 2008b; Chaddock et al, 2009; Mahon et al, 2009; Sussmann et al, 2009; Barysheva et al, 2013) and adolescents (Kafantaris et al, 2009; Chen et al, 2012; Barysheva et al, 2013; Emsell et al, 2013) have shown additional abnormalities in the inferior fronto-occipital fasciculus (IFOF), corona radiata, anterior thalamic radiation (ATR), orbitofrontal regions, subgenual, precuneus, postcentral gyrus, cortical and thalamic association fibers, ILF, CC, cingulum, and inferior and superior fronto-occipital fasciculi (SFOF). DTI whole brain studies using tract-based spatial statistics (TBSS) address some of the limitations of VBM, such as registration of images to a common template, smoothing kernel selection, and adjusting for partial volume effects, via a skeletonization process (Smith et al, 2006).…”