Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Maller, Jerome Joseph; Thaveenthiran, Prasanthan; Thomson, Richard Hilton Siddall; McQueen, Susan; Fitzgerald, Paul B.

doi:10.1016/j.jad.2014.08.016

Cited by 77 publications

(82 citation statements)

References 40 publications

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“…Overall, the most common finding is decreased FA values in commissural and association tracts, particularly in the fronto-limbic tracts (Table 2). 43,53,54 …”

Section: Resultsmentioning

confidence: 99%

“…[29][30][31]40,[43][44][45][46]49 Regarding association tracts, five studies found decreased FA values in the cingulum. 29,43,45,48,49 With respect to the projection tracts, two studies noted decreased FA in the ATR, and one study found decreased FA in the corticospinal tract (CST) ( Table 2).…”

Section: Fa and Wm Tractsmentioning

confidence: 99%

“…With respect to the association tracts, several studies have reported impairment in WM connection in patients with BD, with most indicating impairment in the cingulum 29,[43][44][45]48 and the UF. 40,42,43 The cingulum is a complex fiber system that forms a central component of the entire limbic network where the UF carries association fibers between the medial prefrontal cortex and the anterior temporal lobe, including the amygdala.…”

Section: Continued On Next Pagementioning

confidence: 99%

“…40,42,43 The cingulum is a complex fiber system that forms a central component of the entire limbic network where the UF carries association fibers between the medial prefrontal cortex and the anterior temporal lobe, including the amygdala. These regions have been extensively related to the pathophysiology of BD.…”

Section: Continued On Next Pagementioning

confidence: 99%

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Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Duarte

Silva²,

Goldani³

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To review the available data on diffusion tensor imaging (DTI) of subjects with bipolar disorder (BD), with a particular focus on fractional anisotropy (FA) in white matter (WM) tracts. Methods: The PubMed/MEDLINE database was searched for relevant articles, which were included in a systematic review of the literature. FA reductions and WM abnormalities were divided anatomically into three groups: commissural tracts, association tracts, and projection tracts. Results: Eighteen studies met the inclusion criteria. The corpus callosum was the main impaired commissural tract as demonstrated by FA reductions. Five studies reported FA reductions in the cingulum. Two studies reported decreased FA in the anterior thalamic radiation, and one in the corticospinal tract. Conversely, three studies found increased FA values in WM tracts involved in BD pathophysiology. Conclusion: Despite considerable heterogeneity, these results indicate a direct link between executive cognitive functioning and abnormal WM microstructural integrity of fronto-limbic tracts in patients with remitted BD, providing further evidence of the neuronal disruption that underlies BD symptomatology.

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“…Overall, the most common finding is decreased FA values in commissural and association tracts, particularly in the fronto-limbic tracts (Table 2). 43,53,54 …”

Section: Resultsmentioning

confidence: 99%

Section: Fa and Wm Tractsmentioning

confidence: 99%

Section: Continued On Next Pagementioning

confidence: 99%

Section: Continued On Next Pagementioning

confidence: 99%

See 2 more Smart Citations

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Duarte

Silva²,

Goldani³

et al. 2016

Rev. Bras. Psiquiatr.

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“…The few and small studies that have investigated patients with BDI, BDII and healthy controls suggest that the subtypes are characterized by common neurobiological alterations that are less pronounced in patients with BDII. [13][14][15] One study reported fewer case-control differences in grey matter Background: Bipolar disorder (BD) is a common chronic psychiatric disorder mainly characterized by episodes of mania, hypomania and depression. The disorder is associated with cognitive impairments and structural brain abnormalities, such as lower cortical volumes in primarily frontal brain regions than healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Cortical thickness, volume and surface area in patients with bipolar disorder types I and II

Abé

Ekman

Sellgren

et al. 2016

jpn

107

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IntroductionBipolar disorder (BD) is a common chronic psychiatric disorder characterized by mood disturbances with recurrent episodes of mania, hypomania and depression interspersed by euthymic periods. The disorder is not only associated with premature death, significant disability and impaired psychosocial functioning, 1 but also with cognitive impairments. 2Summarizing previous imaging studies of patients with BD, recent meta-analyses and review articles have concluded that these patients demonstrate abnormalities primarily in frontal lobe regions, such as abnormally low volumes not only in the anterior cingulate cortex (ACC), medial and inferior frontal, orbitofrontal, ventral and dorsolateral prefrontal cortices, but also in the temporal and insular cortices. 3-9There are 2 established subtypes of BD: type I and type II. The subtype BDII is distinguished from BDI mainly by the absence of full-blown manic episodes. This and the generally observed lower functional impairment in patients with BDII compared with BDI 10 has led some to describe BDII as a milder form of BDI. But this conclusion is not necessarily accurate, as BDII is characterized by shorter euthymic intervals, more depressive episodes, longer time spent in a state of depression, more comorbidities and greater perceived suffering than BDI. 11,12 The fact that patients with BDI and BDII manifest different symptoms and severity suggests partly different neurobiological mechanisms and pathophysiology. Despite this, most previous studies have focused on patients with BDI or on patients with BDI and BDII combined indiscriminately. The few and small studies that have investigated patients with BDI, BDII and healthy controls suggest that the subtypes are characterized by common neurobiological alterations that are less pronounced in patients with BDII.13-15 One study reported fewer case-control differences in grey matter Background: Bipolar disorder (BD) is a common chronic psychiatric disorder mainly characterized by episodes of mania, hypomania and depression. The disorder is associated with cognitive impairments and structural brain abnormalities, such as lower cortical volumes in primarily frontal brain regions than healthy controls. Although bipolar disorder types I (BDI) and II (BDII) exhibit different symptoms and severity, previous studies have focused on BDI. Furthermore, the most frequently investigated measure in this population is cortical volume. The aim of our study was to investigate abnormalities in patients with BDI and BDII by simultaneously analyzing cortical volume, thickness and surface area, which yields more information about disease-and symptom-related neurobiology. Methods: We used MRI to measure cortical volume, thickness and area in patients with BDI and BDII as well as in healthy controls. The large study cohort enabled us to adjust for important confounding factors. Results: We included 81 patients with BDI, 59 with BDII and 85 controls in our analyses. Cortical volume, thickness and surface area abnormalities were present ...

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Bipolar Disorders

Janiri¹,

Ambrosi²,

Danese³

et al. 2018

Neuromethods

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Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Cited by 77 publications

References 40 publications

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Neurobiological underpinnings of bipolar disorder focusing on findings of diffusion tensor imaging: a systematic review

Cortical thickness, volume and surface area in patients with bipolar disorder types I and II

Bipolar Disorders

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