Combined analyses of gray matter voxel-based morphometry and white matter tract-based spatial statistics in pediatric bipolar mania

Gao, Weijia; Jiao, Qing; Qi, Rongfeng; Zhong, Yuan; Lu, Dali; Xiao, Qian; Lu, Shengyong; Xu, Chuanjian; Zhang, Yan; Liu, Xiaoqun; Yang, Fan; Lu, Guangming; Su, Linyan

doi:10.1016/j.jad.2013.02.021

Cited by 50 publications

(26 citation statements)

References 64 publications

(78 reference statements)

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“…In a study of unmedicated adolescents in their first episode of mania, FA was decreased in superior frontal WM tracts when compared with findings in HCs (Adler et al, 2006). Similarly, FA in the right anterior cingulate was decreased in youth experiencing a manic episode (Gao et al, 2013a). These two studies are suggestive of increased WM disorganization and/or axonal integrity or myelin breakdown during mania.…”

Section: Discussionmentioning

confidence: 98%

“…DTI whole brain studies using tract-based spatial statistics (TBSS) address some of the limitations of VBM, such as registration of images to a common template, smoothing kernel selection, and adjusting for partial volume effects, via a skeletonization process (Smith et al, 2006). Studies of adolescents with BD using TBSS have found WM aberrations in the CC, fornix, cingulate, and parietal/occipital corona radiata (Barnea-Goraly et al, 2009; James et al, 2011; Lu et al, 2012; Gao et al, 2013b). In summary, previous studies in adults and youth with BD suggest WM tract aberrations in limbic circuitry and major association and commissural tracts.…”

Section: Introductionmentioning

confidence: 99%

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Widespread white matter tract aberrations in youth with familial risk for bipolar disorder

Roybal¹,

Barnea-Goraly

Kelley

et al. 2015

Psychiatry Research: Neuroimaging

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Few studies have examined multiple measures of white matter (WM) differences in youth with familial risk for bipolar disorder (FR-BD). To investigate WM in the FR-BD group, we used three measures of WM structure and two methods of analysis. We used fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) to analyze diffusion tensor imaging (DTI) findings in 25 youth with familial risk for bipolar disorder, defined as having both a parent with BD and mood dysregulation, and 16 sex-, age-, and IQ-matched healthy controls. We conducted a whole brain voxelwise analysis using tract based spatial statistics (TBSS). Subsequently, we conducted a complementary atlas-based, region-of-interest analysis using Diffeomap to confirm results seen in TBSS. When TBSS was used, significant widespread between-group differences were found showing increased FA, increased AD, and decreased RD in the FR-BD group in the bilateral uncinate fasciculus, cingulum, cingulate, superior fronto-occipital fasciculus (SFOF), superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, and corpus callosum. Atlas-based analysis confirmed significant between-group differences, with increased FA and decreased RD in the FR-BD group in the SLF, cingulum, and SFOF. We found significant widespread WM tract aberrations in youth with familial risk for BD using two complementary methods of DTI analysis.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Widespread white matter tract aberrations in youth with familial risk for bipolar disorder

Roybal¹,

Barnea-Goraly

Kelley

et al. 2015

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

show abstract

“…In contrast, cortical volume findings in youths are inconsistent, including decreases or no differences (16,18–23). While there are increasing reports of decreased WM integrity in adolescents with BD, as few studies have focused specifically on anterior paralimbic-heteromodal WM integrity, the extent of abnormalities in those regions in adolescents with BD is not clear (24–30). …”

Section: Introductionmentioning

confidence: 99%

Anterior Cortical Development During Adolescence in Bipolar Disorder

Najt¹,

Wang²,

Spencer³

et al. 2016

Biological Psychiatry

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Background Increasing evidence supports a neurodevelopmental model for bipolar disorder (BD), with adolescence as a critical period in its development. Developmental abnormalities of anterior paralimbic and heteromodal frontal cortices, key structures in emotional regulation processes and central in BD, are implicated. However, few longitudinal studies have been conducted, limiting understanding of trajectory alterations in BD. In this study, we performed longitudinal neuroimaging of adolescents with and without BD and assessed volume changes over time, including changes in tissue overall and within gray and white matter. Larger decreases over time in anterior cortical volumes in the adolescents with BD were hypothesized. Gray matter decreases and white matter increases are typically observed during adolescence in anterior cortices. It was hypothesized that volume decreases over time in BD would reflect alterations in those processes, showing larger gray matter contraction and decreased white matter expansion. Methods Two high-resolution magnetic resonance imaging scans were obtained approximately two-years apart for 35 adolescents with BDI and 37 healthy adolescents. Differences over time between groups were investigated for volume overall and specifically for gray and white matter. Results Relative to healthy adolescents, adolescents with BDI showed greater volume contraction over time in a region including insula, and orbitofrontal, rostral and dorsolateral prefrontal cortices (P<.05, corrected), including greater gray matter contraction and decreased white matter expansion over time, in the BD compared to the healthy group. Conclusions: The findings support neurodevelopmental abnormalities during adolescence in BDI in anterior cortices, include altered developmental trajectories of anterior gray and white matter.

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“…As a result, these measurements have recently been used to investigate white matter microstructural characteristics with converging evidence indicating altered FA patterns in PBD. Specifically, patterns of reduced FA values have been reported in the anterior cingulate, corpus callosum and superior frontal white matter in PBD patients as compared to healthy controls (Gönenç et al, 2010; James et al, 2011; Gao et al, 2013; Adler et al, 2014). …”

Section: Introductionmentioning

confidence: 96%

Predictive classification of pediatric bipolar disorder using atlas-based diffusion weighted imaging and support vector machines

Mwangi¹,

Wu²,

Bauer³

et al. 2015

Psychiatry Research: Neuroimaging

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Previous studies have reported abnormalities of white-matter diffusivity in pediatric bipolar disorder. However, it has not been established whether these abnormalities are able to distinguish individual subjects with pediatric bipolar disorder from healthy controls with a high specificity and sensitivity. Diffusion-weighted imaging scans were acquired from 16 youths diagnosed with DSM-IV bipolar disorder and 16 demographically matched healthy controls. Regional white matter tissue microstructural measurements such as fractional anisotropy, axial diffusivity and radial diffusivity were computed using an atlas-based approach. These measurements were used to `train' a support vector machine (SVM) algorithm to predict new or `unseen' subjects' diagnostic labels. The SVM algorithm predicted individual subjects with specificity = 87.5%, sensitivity = 68.75%, accuracy = 78.12%, positive predictive value = 84.62%, negative predictive value = 73.68%, area under receiver operating characteristic curve (AUROC) = 0.7812 and chi-square p-value = 0.0012. A pattern of reduced regional white matter fractional anisotropy was observed in pediatric bipolar disorder patients. These results suggest that atlas-based diffusion weighted imaging measurements can distinguish individual pediatric bipolar disorder patients from healthy controls. Notably, from a clinical perspective these findings will contribute to the pathophysiological understanding of pediatric bipolar disorder.

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Combined analyses of gray matter voxel-based morphometry and white matter tract-based spatial statistics in pediatric bipolar mania

Cited by 50 publications

References 64 publications

Widespread white matter tract aberrations in youth with familial risk for bipolar disorder

Widespread white matter tract aberrations in youth with familial risk for bipolar disorder

Anterior Cortical Development During Adolescence in Bipolar Disorder

Predictive classification of pediatric bipolar disorder using atlas-based diffusion weighted imaging and support vector machines

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