Volumetric analysis of tumor extent in nasopharyngeal carcinoma and correlation with treatment outcome

Interobserver reliability of computed tomography‐derived primary tumor volume measurement in patients with supraglottic carcinoma

“…4 Numerous studies have shown that the macroscopic ("gross") tumor volume (GTV) at the primary site, as calculated from pretreatment computed tomography (CT) scans, can predict local control in squamous cell carcinoma (SCC) arising in different subsites of the head and neck in patients who are treated with definitive radiation therapy (RT). [5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Larger volume tumors have a higher likelihood of local recurrence than smaller volume lesions arising in the same anatomic subsite. [5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Threshold volumes have been identified in nasopharyngeal, oropharyngeal, supraglottic, pyriform sinus, and T3 glottic carcinomas. [5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control. 6,7,[15][16][17][18] This additional information helps physicians to counsel patients regarding the relative likelihood of local tumor control with primary surgery or RT with or without chemotherapy.…”

“…[5][6][7][8][9][10][11][12][13][14][15][16][17] Several investigators also have shown that there is a stronger association between GTV and local control than the association between T classification and local control. 6,7,[15][16][17][18] This additional information helps physicians to counsel patients regarding the relative likelihood of local tumor control with primary surgery or RT with or without chemotherapy. In regard to laryngeal carcinoma, information regarding the relative risk of local failure based on an objective, quantitative measure of GTV may assist patients in determining the risk they are willing to assume to preserve native laryngeal function.…”

Prognostic Significance of Maximum Primary Tumor Diameter in Nasopharyngeal Carcinoma

“…Previous research demonstrated that the primary tumor volume (PTV) could serve as an important prognostic factor in NPC [5,6]. Chua et al reported that the PTV represented an independent prognostic factor for local control, which appeared to be more predictive than Ho's T stage classification [7]. Sze et al also discovered that the PTV was a highly significant factor for predicting local control in NPC.…”