Voltammetric oxidation of trazodone

Kauffmann, Jean‐Michel; Vire, J. C.; Patriarche, Gaston; Nuñez-Vergara, L.J.; Squella, J.A.

doi:10.1016/0013-4686(87)80028-2

Cited by 60 publications

(29 citation statements)

References 7 publications

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“…As is obvious, the second oxidation process is chemically irreversible. A similar irreversible behavior was reported for the electrooxidation of the piperazine rings of trazodone and doxazosin drug molecules [23,24].…”

Section: Cyclic Voltammetrysupporting

confidence: 52%

“…The cathodic peak is formed as a consequence of the reduction of the ®rst oxidation product of KC. The piperazine ring of the KC molecule is oxidized at high positive potentials (close to the solvent evolution) in a similar process to that reported for the oxidation of the piperazine rings of trazodone [23] and doxazosin molecules [24]. The anodic peak at 870 mV is due to the oxidation of the cathodic peak.…”

Section: Cyclic Voltammetrymentioning

confidence: 75%

“…cation radical is the loss of an electron from the piperazine ring of the KC molecule [23,24]. However, the initial reversible oxidation step may occur as a result of the loss of an electron from either the imidazole ring or the methoxyl group of the drug molecule.…”

Section: Mechanismmentioning

confidence: 99%

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Electrochemical Behavior and Determination of Ketoconazole from Pharmaceutical Preparations

Shamsipur

Farhadi

2000

Electroanalysis

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The oxidation of ketoconazole (KC) was investigated by rotating disk electrode voltammetry, cyclic voltammetry, and controlled potential coulometry in chloroform at platinum (Pt), gold (Au), and glassy carbon (GC) electrodes using tetrabutylammonium perchlorate as supporting electrolyte. Based on the electrochemical results obtained, the following possible mechanism was proposed to explain the electrochemical oxidation of KC KC Àe ÀÀÀB AÀÀÀ KC Á À À À? Àe P j ; P H A differential pulse voltammetric method at a Pt electrode was developed for the determination of KC from pharmaceutical preparations in the concentration of 3.0610 76 ±1.061074 M. The procedure was applied to the determination of KC in its tablets and creams as well as its recovery from blood serum and urine samples.

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Section: Cyclic Voltammetrysupporting

confidence: 52%

Section: Cyclic Voltammetrymentioning

confidence: 75%

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Electrochemical Behavior and Determination of Ketoconazole from Pharmaceutical Preparations

Shamsipur

Farhadi

2000

Electroanalysis

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“…The official method for analysis of trazodone hydrochloride based on HPLC using octadecylsilane column and water-0.01 M ammonium phosphate buffer pH 6.0 (60: 40) as mobile phase 2 and potentiometric non-aqueous titration with perchloric acid 3 .The analytical methods that are reported for the determination of trazodonehydrochloride in pharmaceutical formulations include spectrophoto-metric methods [4][5][6][7] ion-selective electrodes 8,9 voltammetry [10][11][12][13] and various chromatographic methods including; HPLC 2,[14][15][16][17] capillary gas chromatography 18 , liquid chromatography-tandem mass spectrometry 19 and instrumental thin layer chromatography 20 . Also, spectrofluorimetric methods have been reported 21,22 .…”

Section: Introductionmentioning

confidence: 99%

Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

Salama

Attia

Said

et al. 2018

Journal of Advanced Pharmacy Research

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Objectives: Conductometric determination of trazodone hydrochloride, with two precipitating reagents; Ammonium Reineckate and sodium tetraphenylborate has been investigated. Methods: The formed ion-associates were studied conductomterically for the determination of solubility products and other functions associated with the process of precipitating trazodone hydrochloride were determined. Moreover, two new maneuvers towards equivalence point detection were carried out. In this study, data processing was performed using numerical derivatization (second derivative) and Boltzmann algorithm. Results: Although, the described procedures allowed the determination of trazodone hydrochloride within the range of 2-14 mg using both reagents has less sensitivity other than reported method but has more advantages in simplicity, low cost , relatively short analysis time and direct analysis with good recoveries between 100.01% and 100.07% with relative standard deviation less than 2%. Conclusion: These methods were validated and successfully applied for the determination of trazodone hydrochloride in Trittico ® tablets. The obtained results were statistically compared with those of the official method by applying t-test and F-value at 95% confidence level and no significant difference was observed regarding accuracy and precision.

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“…3 A literature survey revealed that several techniques have been developed for the quantitative determination of trazodone hydrochloride in pharmaceutical formulations, including spectrophotometric methods, [4][5][6][7][8][9] potentiometric methods, 10,11 voltammetry, [12][13][14][15] and different chromatographic methods including HPLC, 3,16-21 capillary gas chromatography, 22 high-performance liquid chromatographytandem mass spectrometry, 23,24 and high performance thin layer chromatography. 25 In addition, spectrouorimetric methods have been reported.…”

mentioning

confidence: 99%

Disposable gold nanoparticle functionalized and bare screen-printed electrodes for potentiometric determination of trazodone hydrochloride in pure form and pharmaceutical preparations

et al. 2018

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In the present study, screen-printed electrodes unmodified and chemically modified with gold nanoparticles were used as sensitive electrochemical sensors for the determination of trazodone hydrochloride. The sensors were based on the use of a tetraphenylborate ion association complex as an electroactive material in screen-printed electrodes with dioctyl phthalate (DOP) as a solvent mediator modified with gold nanoparticles which improve the electrode conductivity and enhance the surface area. The sensors displayed a stable response for 5, 6 and 7 months with a reproducible potential and linear response over the concentration range 1 Â 10 , 7.6 Â 10 À6 and 6.8 Â 10 À6 mol L À1 for sensor 1, 2 and 3 respectively. The analytical performance of the screen printed electrodes in terms of selectivity coefficients for trazodone hydrochloride relative to the number of potentially interfering substances was investigated. The proposed method has been applied successfully for the analysis of the drug in its pure and dosage forms and there is no interference from any common pharmaceutical additives.

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Voltammetric oxidation of trazodone

Cited by 60 publications

References 7 publications

Electrochemical Behavior and Determination of Ketoconazole from Pharmaceutical Preparations

Electrochemical Behavior and Determination of Ketoconazole from Pharmaceutical Preparations

Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

Disposable gold nanoparticle functionalized and bare screen-printed electrodes for potentiometric determination of trazodone hydrochloride in pure form and pharmaceutical preparations

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