Conductometric Titration for Determination of Trazodone Hydrochloride and Solubility Products of its Ion-Associated Complex Species

Abstract

Objectives: Conductometric determination of trazodone hydrochloride, with two precipitating reagents; Ammonium Reineckate and sodium tetraphenylborate has been investigated. Methods: The formed ion-associates were studied conductomterically for the determination of solubility products and other functions associated with the process of precipitating trazodone hydrochloride were determined. Moreover, two new maneuvers towards equivalence point detection were carried out. In this study, data processing was performed using numerical derivatization (second derivative) and Boltzmann algorithm. Results: Although, the described procedures allowed the determination of trazodone hydrochloride within the range of 2-14 mg using both reagents has less sensitivity other than reported method but has more advantages in simplicity, low cost , relatively short analysis time and direct analysis with good recoveries between 100.01% and 100.07% with relative standard deviation less than 2%. Conclusion: These methods were validated and successfully applied for the determination of trazodone hydrochloride in Trittico ® tablets. The obtained results were statistically compared with those of the official method by applying t-test and F-value at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Versatile Sensor Modified with Gold Nanoparticles Carbon Paste Electrode for Anodic Stripping Determination of Brexpiprazole: A Voltammetric Study

“…2 It is practically insoluble in water and freely soluble in methanol. 3 A review of the literature summarize briefly a small number of analytical methods described for the determination of BRX in its dosage form by HPLC method [4][5][6][7][8][9] and in human urine sample with its metabolites using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF). 10 Only one UV spectrophotometric method was reported for determination of BRX by direct measurement at 215 nm using methanol as a solvent.…”