Voltammetric determination of wedelolactone, an anti-HIV herbal drug, at boron-doped diamond electrode

Abstract

Boron-doped diamond electrode has been utilized for the study of electrochemical behaviour of an anti-HIV herbal drug wedelolactone in Britton-Robinson buffer (pH-2.5) by square-wave and cyclic voltammetry techniques. The response characteristics of cyclic voltammetry and square wave voltammetry showed a remarkable increase in the anodic peak current and electrochemical impedance spectroscopy revealed a lowering in charge transfer resistance at the boron-doped diamond electrode as compared to the glassy carbon electrode that can be attributed to the higher sensitivity of boron-doped diamond sensor. Cyclic voltammetry at the boron-doped diamond surface revealed the oxidation of wedelolactone with two oxidation peaks (P 1 and P 2 ) with Ep 1 = 0.4V and Ep 2 =1.00 V with scan rate varying from 10 -220 mV/s and exhibits diffusion-controlled process. Based on the electrochemical measurements, a probable oxidation mechanism has been deduced and the electrode dynamics parameters have been evaluated. The effect of concentration on the peak currents of wedelolactone was found to have a linear relationship within the concentration range of 50-700 ng/mL. The LOD and LOQ were found to be 43.87 and 132.93 ng/mL respectively. The applicability of the proposed method was further scrutinized by the successful determination of wedelolactone in real plant samples.

Analytical Applications of Electrochemically Pretreated Boron‐Doped Diamond Electrodes

“…Interestingly, in the last decade or so, there were many reports of different analytical applications based on CPT‐BDDEs, but lacking comparisons with the performance of the APT or as‐grown electrode; the CPT may have been preceded or not by an APT. This direct, trustful use of CPT‐BDDEs is most probably based on the understanding that HT‐BDD surfaces are hydrophobic and thus might better interact with the investigated analyte, consequently resulting in a higher intensity of the current signal …”

TiO2/Graphene/Chitosan-Nanocomposite-Based Electrochemical Sensor for the Sensing of Anti-HIV Drug Topotecan

“…Additional application of electrochemistry includes the determination of the redox properties of drugs which provides an insight into their metabolic fate and the in-vivo redox process which makes it easier to understand the pharmacological activities. [15][16][17][18][19][20][21][22][23][24] The development of electrochemical sensors for the analysis of pharmaceutically important compounds with respect to their sensitivity, accuracy, and simplicity have been of greater interest in recent years.Modified electrodes have recently received tremendous interest largely because they have a wide range of potential applications in electrochemical technology, energy conversion, and, particularly, in chemical analysis. 25-30 Nanomaterials exploitation to develop the sensitive potentiometric sensors is now one of the most interesting research fields, because of their high electrocatalytic activity, lowering of overpotentials, good adsorption characteristics, enhanced surface area, and high conductivity with increased electron transfer rate.…”

“…Additional application of electrochemistry includes the determination of the redox properties of drugs which provides an insight into their metabolic fate and the in-vivo redox process which makes it easier to understand the pharmacological activities. [15][16][17][18][19][20][21][22][23][24] The development of electrochemical sensors for the analysis of pharmaceutically important compounds with respect to their sensitivity, accuracy, and simplicity have been of greater interest in recent years.…”