Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Pham, Thi Hai Yen; Trang, Thi Thu; Nguyen, Hoang Anh; Chu, Thi Thu Hien; Vu, Thi Thu Ha; Le, Quoc Hung

doi:10.1155/2021/8823452

Cited by 15 publications

(5 citation statements)

References 57 publications

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“…This result is consistent with previous studies on similar electrochemical systems. 37,[44][45][46][47] Reproducibility of the FeBTC@CPE electrode.-For electrode performance evaluation, the repeatability and reproducibility were investigated in AMX solution.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Nanostructured Mixed-Valence Fe(II,III) Metal-Organic Framework and Its Application in Electrochemical Sensing of Amoxicillin

Nguyên

Nguyen

et al. 2023

J. Electrochem. Soc.

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The study reports the development of a nanostructured mixed-valence Fe(II)Fe(III)BTC metal-organic framework (BTC = 1,3,5-benzenetricarboxylate) modified carbon paste electrode as a novel sensor for the amoxicillin detection in aqueous solutions using square wave voltammetry. The physicochemical properties of FeBTC were characterized using X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, Brunauer-Emmett-Teller analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy. These techniques revealed that FeBTC has a surface area of 1211 m2/g, a total pore volume of 1.46 cm3/g, particle sizes ranging from 10 to 20 nm, and a mixed-valence structure. Furthermore, SEM, TEM, and energy-dispersive X-ray spectroscopy showed homogeneous distribution of FeBTC throughout the modified electrode. The electrochemical study showed that the mixed-valence FeBTC improved the electron transfer capabilities of the electrode. Under optimal conditions, the modified electrode exhibited a significant increase in peak height compared to the unmodified electrode (4.6 times higher), with an acceptable reproducibility of 4.88% relative standard deviation. The linear range of the sensor was 1-100 µM with a good coefficient of determination of 0.9985, and a detection limit of 0.107 µM. Additionally, the sensor demonstrated excellent performance with the satisfactory recoveries and a good correlation with LC-MS/MS analysis.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Nanostructured Mixed-Valence Fe(II,III) Metal-Organic Framework and Its Application in Electrochemical Sensing of Amoxicillin

Nguyên

Nguyen

et al. 2023

J. Electrochem. Soc.

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“…The drug Amoxycillin trihydrate is mixed with the polymer mixture. The ATR-FTIR analysis for the drug-polymer mixture was carried out as described by Wood et al 20,21 .…”

Section: Drug Excipient Interaction Study Using Ftir Spectroscopymentioning

confidence: 99%

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2023

IJPSR

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Novel drug delivery approach by using natural polymers is a newer area of formulation development. The oral drug delivery in the buccal cavity to treat the dental infections has some limitations such as slow onset of actions and is also affected by the first pass metabolism. In order to overcome these challenges plant derived mucoadhesive gum from the fruit pulp of Ziziphus mauritiana L.(ZM) is used in the preparation of Denticap and evaluated in vitro for to analysis its sustained release action. Antibacterial drug Amoxycillin Trihydrate has been taken as the model drug. The denticap was formulated using Carbopol 934P, Z Mgum, Ethyl cellulose and ethanol by solvent evaporation technique. The physicochemical parameters such as swelling index, surface pH, tooth adhesion test etc were carried out. The swelling % ranges from 40-55%. The tooth adhesive strength and pH was 45g and 6.7 respectively. The cumulative drug release from the ZM denticap was found to be 67% at 30 hr. The drug release kinetic study shows that formulation follows diffusion mechanism. The antibacterial study against various oral infection pathogens like Lactobacillus acidophillus, Staphylococcus aureus, Porphyromonas Gingivalis and Streptococcus mutans showed that the ZM gum possess certain antibacterial activity. SEM study shows the surface morphology of the denticap. The stability study following ICH guidelines shows that the formulation is stable. The formulated Denticap using ZM gum is a newer approach for sustained delivery of drug for treatment of dental infections. INTRODUCTION:Plants have been used in the traditional system of medicine for several thousand years. The development of various excipients that can be used in formulation development is moving toward utilizing natural sources in the modern world 1, 2 . Presently, many polysaccharides are identified and isolated from various plant sources 3, 4 . They are used in various formulations such as tablets, emulsions, suspensions, microparticle nanoparticles etc. Thus, to fulfill the increasing industrial demands for plant polysaccharides, it is vital to explore newer sources 5 .

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“…It is difficult to imagine modern medicine without antibiotics. However, their uncontrolled use has led to antibiotic contamination of ecosystems and food [1][2][3][4]. This has increased the already high level of resistance of many bacteria to antimicrobial drugs.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric sensor based on molecular imprinted polymer for lincomycin determination

et al. 2023

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For the selective detection of the antibiotic lincomycin, we developed a voltammetric sensor based on a glassy carbon electrode modified with reduced graphene oxide and polyarylenephthalide containing diphenylenethio and diphenyleneoxide fragments in the main chain of the polymer in the 1:1 ratio with lincomycin molecular imprints obtained by phase inversion. Using FTIR spectroscopy, electrochemical impedance spectroscopy, cyclic and differential-pulse voltammetry, the electrochemical and analytical characteristics of the sensor were studied. The detection of lincomycin was carried out by differential pulse voltammetry. The linear concentration range was 2.5·10–7–5·10–4 M with a limit of detection of 6.8·10–8 M. It was shown that the presence of molecular imprints increases the sensitivity of the developed sensor in comparisons with a sensor with non-imprinted polymer by a factor of 3.05.

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Voltammetric Determination of Amoxicillin Using a Reduced Graphite Oxide Nanosheet Electrode

Cited by 15 publications

References 57 publications

Synthesis of Nanostructured Mixed-Valence Fe(II,III) Metal-Organic Framework and Its Application in Electrochemical Sensing of Amoxicillin

Synthesis of Nanostructured Mixed-Valence Fe(II,III) Metal-Organic Framework and Its Application in Electrochemical Sensing of Amoxicillin

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Voltammetric sensor based on molecular imprinted polymer for lincomycin determination

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