For the selective detection of the antibiotic lincomycin, we developed a voltammetric sensor based on a glassy carbon electrode modified with reduced graphene oxide and polyarylenephthalide containing diphenylenethio and diphenyleneoxide fragments in the main chain of the polymer in the 1:1 ratio with lincomycin molecular imprints obtained by phase inversion. Using FTIR spectroscopy, electrochemical impedance spectroscopy, cyclic and differential-pulse voltammetry, the electrochemical and analytical characteristics of the sensor were studied. The detection of lincomycin was carried out by differential pulse voltammetry. The linear concentration range was 2.5·10–7–5·10–4 M with a limit of detection of 6.8·10–8 M. It was shown that the presence of molecular imprints increases the sensitivity of the developed sensor in comparisons with a sensor with non-imprinted polymer by a factor of 3.05.
The recognition and determination of enantiomers plays an important role in modern medicine and pharmaceuticals, since living organisms react differently to their presence in medicines. Currently, chromatographic and spectrometric methods are often used to determine enantiomers, but the use of electrochemical methods can theoretically become a more cost-effective alternative due to their relative cheapness of instruments, rapidity, and low consumption of reagents. In this regard, enantioselective voltammetric sensors (EVS) are receiving increasing attention.
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