Topic: Optical DevicesInternational audienceWe present a simple method to determine simultaneously the main characteristics of passive or active high-Q optical resonators. The method is based on cavity ringdown spectroscopy, where the probe wavelength is rapidly swept across the resonance. It has already been shown that this technique allows the loaded cavity lifetime of passive resonators to be obtained. We show that we can also infer the coupling regime for passive resonators and the resonant gain for active resonators. The method is tested on Er3+ doped fiber resonators and also applied to determine the intrinsic and external Q-factors of an MgF2 whispering gallery mode resonator

Obesity is a global pandemic and it is well evident that obesity is associated with the development of many disorders including many cancer types. Breast cancer is one of that associated with a high mortality rate. Adipocytes, a major cellular component in adipose tissue, are dysfunctional during obesity and also known to promote breast cancer development both in vitro and in vivo. Dysfunctional adipocytes can release metabolic substrates, adipokines, and cytokines, which promote proliferation, progression, invasion, and migration of breast cancer cells. The secretion of adipocytes can alter gene expression profile, induce inflammation and hypoxia, as well as inhibit apoptosis. It is known that excessive free fatty acids, cholesterol, triglycerides, hormones, leptin, interleukins, and chemokines upregulate breast cancer development. Interestingly, adiponectin is the only adipokine that has anti-tumor properties. Moreover, adipocytes are also related to chemotherapeutic resistance, resulting in the poorer outcome of treatment and advanced stages in breast cancer. Evaluation of the adipocyte secretion levels in the circulation can be useful for prognosis and evaluation of the effectiveness of cancer therapy in the patients. Therefore, understanding about functions of adipocytes as well as obesity in breast cancer may reveal novel targets that support the development of new anti-tumor therapy. In this systemic review, we summarize and update the effects of secreted factors by adipocytes on the regulation of breast cancer in the tumor microenvironment.

Ultrahigh-quality (Q) factor microresonators have a lot of applications in the photonics domain ranging from low-threshold nonlinear optics to integrated optical sensors. Glass-based whispering gallery mode (WGM) microresonators are easy to produce by melting techniques, however they suffer from surface contamination which limits their long-term quality factor to a few 108. Here we show that an optical gain provided by erbium ions can compensate for residual losses. Moreover it is possible to control the coupling regime of an ultrahigh Q-factor three port microresonator from undercoupling to spectral selective amplification by changing the pumping rate. The optical characterization method is based on frequency-swept cavity-ring-down-spectroscopy. This method allows the transmission and dispersive properties of perfectly transparent microresonators and intrinsic finesses up to 4.0 × 107 to be measured. Finally we characterize a critically coupled fluoride glass WGM microresonator with a diameter of 220 μm and a loaded Q-factor of 5.3 × 109 is demonstrated.