Voltammetric Analysis in Blood Serum in Patients with Severe Combined Trauma

Tsivadze, A. Yu.; Петриков, С. С.; Goroncharovskaya, I. V.; Евсеев, А. К.; Шабанов, А. К.; Batishchev, Oleg V.; Андреев, В. Н.; Goldin, Mark M.

doi:10.1134/s0012501619050014

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…In order to obtain more complete information about changes in the components of this balance, we examined antioxidant capacity of blood serum using CV method. It has been found that at the time of admission, the value of antioxidant capacity, expressed in the amount of electricity spent for oxidation of antioxidants, was 25 (19; 29) μC and was within the range of Q values found for apparently healthy people (22 (19; 25) μC [34]) (Figure 2).…”

Section: Resultsmentioning

confidence: 56%

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Electrochemical Methods for Assessment of Polytrauma Outcomes

et al. 2020

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In this work we used electrochemical methods, open circuit potential (OCP) measurement with platinum electrode, and cyclic voltammetry (CV) in blood serum to assess redox states in patients with polytrauma (n=56) that allow to evaluate probability of survival early on, and therefore have the potential to improve therapy outcomes. Electrochemical assessment of redox states in sera samples correlated with traditional methods of prooxidant/antioxidant balance quantification. OCP and quantity of electricity passed (Q), calculated from CVs, were significantly different between the survivors and non‐survivors. Patients with Q>22 μC (day 1) and OCP>34 mV (day 3) had low chance of survival.

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Section: Resultsmentioning

confidence: 56%

“…The examined patients were divided into 2 groups according to the trauma outcome criterion: the group of survivors and the group of non‐survivors. As reference values, we used the data of blood serum analysis of practically healthy volunteers, which we obtained earlier [8, 34].…”

Section: Methodsmentioning

confidence: 99%

Electrochemical Methods for Assessment of Polytrauma Outcomes

et al. 2020

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“…It is worth mentioning that attempts to study blood serum voltammetrically date back to the early works of Koryta et al [5,6], where CV was applied at a Pt electrode. More recent studies have used CV to detect antioxidants or to generally characterize the redox status of a serum [41,42]. However, when comparing the typical SW voltammetric pro le of a serum sample (red curve in Fig.…”

Section: Discussionmentioning

confidence: 99%

Square-Wave Voltammetry of Human Blood Serum

Kokoškarova

Stojanov

Najkov

et al. 2023

Preprint

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A study on voltammetric analysis of whole blood serum is presented using advanced square-wave voltammetry at an edge plane pyrolytic graphite electrode. The results demonstrate that even in a complex medium like human blood serum, electrochemical characterization can be achieved through the use of advanced voltammetric techniques in conjunction with an appropriate commercially available electrode, such as the edge plane pyrolytic graphite electrode, which boasts superior electrocatalytic properties. Without undergoing any chemical treatment of the serum sample, the square-wave voltammetry technique reveals, for the first time, the electrode reactions of uric acid, bilirubin, and albumin in a single experiment, as represented by well-defined, separated, and intense voltammetric signals. All electrode processes are surface-confined, indicating that the edge plane sites of the electrode serve as an ideal platform for the competitive adsorption of electroactive species, despite the extensive chemical complexity of the serum samples. The speed and differential nature of square-wave voltammetry are crucial for obtaining an outstanding resolution of the voltammetric peaks, maintaining the quasi-reversible nature of the underlying electrode processes, while reducing the impact of follow-up chemical reactions that are coupled to the initial electron transfer for all three detected species, and minimizing fouling of the electrode surface.

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Square-wave voltammetry of human blood serum

Kokoškarova

Stojanov

Najkov

et al. 2023

Sci Rep

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A study on voltammetric analysis of blood serum diluted in a phosphate buffer is presented using advanced square-wave voltammetry at an edge plane pyrolytic graphite electrode. The results demonstrate that even in a complex medium like human blood serum, electrochemical characterization can be achieved through the use of advanced voltammetric techniques in conjunction with an appropriate commercially available electrode, such as the edge plane pyrolytic graphite electrode, which boosts superior electrocatalytic properties. Without undergoing any chemical treatment of the serum sample, the square-wave voltammetry technique reveals, for the first time, the electrode reactions of uric acid, bilirubin, and albumin in a single experiment, as represented by well-defined, separated, and intense voltammetric signals. All electrode processes are surface-confined, indicating that the edge plane sites of the electrode serve as an ideal platform for the competitive adsorption of electroactive species, despite the extensive chemical complexity of the serum samples. The speed and differential nature of square-wave voltammetry are crucial for obtaining an outstanding resolution of the voltammetric peaks, maintaining the quasi-reversible nature of the underlying electrode processes, while reducing the impact of follow-up chemical reactions that are coupled to the initial electron transfer for all three detected species, and minimizing fouling of the electrode surface.

show abstract

Voltammetric Analysis in Blood Serum in Patients with Severe Combined Trauma

Cited by 4 publications

References 12 publications

Electrochemical Methods for Assessment of Polytrauma Outcomes

Electrochemical Methods for Assessment of Polytrauma Outcomes

Square-Wave Voltammetry of Human Blood Serum

Square-wave voltammetry of human blood serum

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