Vogt‐Koyanagi‐Harada's Syndrome Associated with Hashimoto's Thyroiditis

Chi, Hyung-In; Furue, Masutaka; Ishibashi, Yoshihiro

doi:10.1111/j.1346-8138.1994.tb01817.x

Cited by 15 publications

(14 citation statements)

References 6 publications

(8 reference statements)

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“…sively in darkly pigmented individuals (for review Vogt-Koyanagi-Harada (VKH) disease is an un-see Rao et al, 1995). All of these affected organs common systemic disorder characterized by panu-contain melanocytes and this disease often accomveitis associated with disorders of skin (e.g., panies human leucocyte antigen (HLA)-DR4 (Davis vitiligo, alopecia, and poliosis), inner ear (e.g., tin-et al, 1990;Shindo et al, 1994;Pivetti-Pezzi et al, 19961, which is related to autoimmune diseases and is sometimes associated with autoimmune diseases themselves (Cavalli et al, 1985;Chi et al, 1994;Jovic et al, 1996). Thus, it is tempting to conceive that this disease is an autoimmune disease whose targets are melanocyte-specific proteins (as in the case of vitiligo), and the following findings are consistent with this hypothesis.…”

Section: Healthy Melanocytes Are Required For Normal Strial Functionmentioning

confidence: 99%

Sound Needs Sound Melanocytes to Be Heard

Tachibana

1999

Pigment Cell Research

118

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Intermediate cells in the stria vascularis of the mammalian cochlea are melanocytes, which contain melanin pigments and are capable of synthesizing melanin. These melanocytes are required for normal development of the cochlea, as evidenced by studies of mutant mice with congenital melanocyte anomalies. Melanocytes are also needed for developed cochleae to function normally, as evidenced by studies of mutant mice with late-onset melanocyte anomaly and humans with acquired melanocyte anomaly. Melanin, per se, does not seem to be essential for normal hearing function, but it may protect against traumata to the cochlea, e.g., noise and ototoxic aminoglycosides. Recent electrophysiological studies have revealed that strial intermediate cells are provided with specific ionic channels, such as inwardly rectifying K+ channels (Kir4.1) and voltage-dependent outwardly rectifying K+ channels. These channels may play central roles in strial function and thus in normal hearing.

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Section: Healthy Melanocytes Are Required For Normal Strial Functionmentioning

confidence: 99%

Sound Needs Sound Melanocytes to Be Heard

Tachibana

1999

Pigment Cell Research

118

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“…4 , 7 –9 , 11 , 12 In our case, complete blood counts and biochemical parameters, including T 3 and T 4 , were also performed with normal results. Thyroid evaluation was indicated as thyroiditis may be associated with VKH syndrome in humans 23 …”

Section: Discussionmentioning

confidence: 99%

Uveodermatological syndrome (Vogt–Koyanagi–Harada‐like syndrome) with generalized depigmentation in a Dachshund

Herrera

Duchene

1998

Veterinary Ophthalmology

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A 3-year-old, female, black and tan Dachshund was referred with visual impairment, bilateral anterior and posterior uveitis, poliosis, and generalized dermal depigmentation. Complete blood counts and biochemical parameters, including T3 and T4, were normal. The skin biopsy showed lichenoid dermatoses with dermal infiltration of histiocytes and lymphocytes suggesting uveodermatological syndrome. Medical treatment was initiated with oral prednisone and azathioprine, and topical prednisolone and atropine. The clinical signs improved, vision was retained, and the skin began to repigment 2 months following the initiation of therapy.

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“…Treatment of VKH syndrome is based on steroids and immunosuppressors and treatment of hypothyroidism is substitutive thyroid hormone. Captopril establishes myocarditis; when due to hypothyroidism, it is also reversible when hormonal disorder is early corrected [1,7,11,13].…”

Section: Discussionmentioning

confidence: 99%

“…This was mainly Hashimoto's disease [4][5][6][7][8], more rarely with Graves' disease [9] or polyglandular syndrome [10]. The pathogenesis of Hashimoto's thyroiditis appears to involve humoral immunity as evidenced by the presence of anti-thyroid, but also cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada syndrome associated to hypothyroidism revealed by myocarditis

Ismail¹,

Mzabi²,

Karmani³

et al. 2012

OJIM

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Purpose: Vogt-Koyanagi-Harada (VKH) syndrome is usually defined as an uveo-meningitis who may be associated with auditory and cutaneous signs. Association of VKH syndrome and autoimmune thyroiditis is uncommon. Observation: A 28-year-old man was admitted with thoracic pain due to myocarditis. Two years ago he presented VKH syndrome with specific ocular manifestation and deafness, treated by corticosteroids and immunosuppressive. Etiologic investigation of myocarditis concluded to deep hypothyroidism related to Hashimoto thyroiditis. The patient improved after substitutive treatment by thyroid hormones. Conclusion: Thyroid function should be systematically investigated in case of VKH syndrome and particularly when associated to dysthyroidism symptoms.

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Vogt‐Koyanagi‐Harada's Syndrome Associated with Hashimoto's Thyroiditis

Cited by 15 publications

References 6 publications

Sound Needs Sound Melanocytes to Be Heard

Sound Needs Sound Melanocytes to Be Heard

Uveodermatological syndrome (Vogt–Koyanagi–Harada‐like syndrome) with generalized depigmentation in a Dachshund

Vogt-Koyanagi-Harada syndrome associated to hypothyroidism revealed by myocarditis

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