Uveodermatological syndrome (Vogt–Koyanagi–Harada‐like syndrome) with generalized depigmentation in a Dachshund

Abstract

A 3-year-old, female, black and tan Dachshund was referred with visual impairment, bilateral anterior and posterior uveitis, poliosis, and generalized dermal depigmentation. Complete blood counts and biochemical parameters, including T3 and T4, were normal. The skin biopsy showed lichenoid dermatoses with dermal infiltration of histiocytes and lymphocytes suggesting uveodermatological syndrome. Medical treatment was initiated with oral prednisone and azathioprine, and topical prednisolone and atropine. The clinical signs improved, vision was retained, and the skin began to repigment 2 months following the initiation of therapy.

Uveodermatologic syndrome in a Brazilian Fila dog

“…(1977) 2 . Since then, several other affected breeds including the Siberian Husky, Dachshund, Fox Terrier, Shetland Sheepdog, Saint Bernard, Irish Setter, Old English Sheepdog, and Chow‐Chow have been reported 3–10 …”

Canine Secondary Glaucomas

“…The condition was first described in Akitas, although it has since been diagnosed in several other breeds. 30,[124][125][126][127] Akitas with a particular dog leukocyte antigen haplotype are thought to be at greater risk of developing the disease, suggesting an immunemediated pathogenesis. 128 UDS is characterized by a severe granulomatous anterior uveitis and chorioretinitis.…”

Canine and Feline Uveitis

“…Affected patients are usually presented with anterior uveitis or panuveitis characterized by iridal or choroidal depigmentation, bullous retinal detachment, or blindness [3]. The ocular lesions may precede the cutaneous lesions, which include poliosis and vitiligo of the facial mucocutaneous junctions, nasal planum, scrotum, and footpads [81,82]. Generalized vitiligo may also occur [81].…”

“…The ocular lesions may precede the cutaneous lesions, which include poliosis and vitiligo of the facial mucocutaneous junctions, nasal planum, scrotum, and footpads [81,82]. Generalized vitiligo may also occur [81]. Because of the chronic nature of the disease, affected patients typically develop extensive posterior synechia, iris bombé, cataract, and secondary glaucoma.…”