Vogt–Koyanagi–Harada disease occurring during interferon-alpha and ribavirin therapy for chronic hepatitis C virus infection

Al-Muammar, Abdulrahman; Al-Mudhaiyan, Tariq M.; Otaibi, Mohammed Al; Abdo, Ayman A.; El‐Asrar, Ahmed M. Abu

doi:10.1007/s10792-010-9357-0

Cited by 15 publications

(7 citation statements)

References 8 publications

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“…Some scholars believe that viral infection may be an important cause of VKHD. The clinical samples involved in such studies include cerebrospinal fluid aqueous humour and serum, and the types of viruses tested include herpes simplex virus (HSV), herpes zoster virus (VZV), cytomegalovirus (CMV), Epstein‒Barr virus (EBV) and human herpes virus type 6 (HHV-6) [ 32 , 50 – 52 ]. The research trends related to viral infection have declined in the past five years, but it is worth noting that many clinical studies and case reports in the past three years found that VKHD was associated with COVID-19 as well as with the COVID-19 vaccine [ 54 – 61 ].…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

Li¹,

Liu²,

Zhou³

et al. 2023

Int Ophthalmol

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Purpose As an autoimmune disease, Vogt‒Koyanagi‒Harada disease (VKHD) is a main type of uveitis in many countries and regions, significantly impacting patient vision. At present, information regarding VKHD is still limited, and further research is needed. We conducted a bibliometric analysis to characterize the overall status, current trends, and current focus of VKHD research. Method Literature published from 1975 to 2022 was obtained from the Web of Science core collection and analysed with the R-language packages Bibliometrix, VOSviewer, and CiteSpace software. Results A total of 1050 papers on VKHD were retrieved from 261 journals, and 16,084 references were obtained from the papers in the original search. The average annual number of published articles was approximately 21.9, and the number of publications rapidly increased after 2004. The journal Ocular Immunology and Inflammation published the most papers on VKHD, while the American Journal of Ophthalmology has the highest citation frequency. The leading countries were Japan, China (PRC), and the United States of America (USA). Yang PZ from Chongqing Medical University was the most prolific and cited author. The most frequently cited study discussed revision of VKHD diagnostic criteria. An analysis of the highest frequency keywords showed that most research focused on the treatment, diagnosis, and pathogenesis of VKHD and its relationship with other related diseases. At present, the most urgent research direction is in the relationship between COVID-19 or COVID-19 vaccines and VKHD and the corresponding mechanisms underlying it. Conclusion Utilizing dynamic and visualization tools, bibliometrics provides a clear depiction of the research history, development trends, and research hotspots in VKHD It serves as a valuable tool for identifying research gaps and areas that necessitate further exploration. Our study revealed potential directions for future VKHD research, including investigating specific molecular mechanisms underlying the disease, exploring the clinical utility of optical coherence tomography angiography and other diagnostic techniques, and conducting clinical research on novel therapeutic drugs.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

Li¹,

Liu²,

Zhou³

et al. 2023

Int Ophthalmol

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“…Vogt-Koyanagi-Harada (VKH) syndrome and panuveitis are also described in patients during IFN treatment (21,79) . The diagnosis of VKH is confirmed by retinal fluorescein angiography, typically showing multiple dots in the retinal pigment epithelium, and bilateral serous retinopathy and serous retinal detachment in combination with papillitis and optic disc edema (80) .…”

Section: Ocular Changes Associated With Ifn and Ribavirin Treatmentmentioning

confidence: 98%

O olho na hepatite C: uma revisão

Bertrand

Gomes

et al. 2019

Arquivos Brasileiros De Oftalmologia

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| This review aims to caution ophthalmologists about the ocular consequences leading to the diagnosis of hepatitis C virus infection. In addition, in this context, the effects of old and new drugs are discussed in the ophthalmological setting. The importance of early diagnosis and the curative treatment of the disease has been reported in the national and international literature, demonstrating that its progression has important implications for daily clinical and surgical ophthalmological practice. Despite the scarcity of studies on new direct-acting antiviral drugs, fewer side effects of these drugs have been shown when compared with conventional interferon treatment with or without ribavirin. The ophthalmologist's risk of becoming infected, as demonstrated by the presence of the virus in ocular structures, and the possibility of contamination, is also discussed.Keywords: Hepatitis C/ complications; Hepatitis C/drug therapy; Interferon/therapeutic use; Direct-acting antiviral drugs RESUMO | Esta revisão objetiva alertar os oftalmologistas sobre as consequências oculares que levam ao diagnóstico da infecção pelo vírus da Hepatite C. Além disso, neste contexto, os efeitos de drogas antigas e novas são discutidos no cenário oftalmológico. A importância do diagnóstico precoce e do tratamento curativo da doença tem sido relatada na literatura nacional e internacional, demonstrando que sua progressão tem implicações importantes para a prática oftalmológica diária. Apesar da escassez de estudos sobre novos medicamentos antivirais de ação direta, foram demonstrados menos efeitos colaterais desses medicamentos quando comparados ao tratamento convencional com interferon, com ou sem ribavirina associado ou não à rivabirina. O risco do oftalmologista de se infectar, como demonstrado pela presença do vírus nas estruturas oculares, e a possibilidade de contaminação, também é discutido.Descritores: Hepatite C/complicações; Hepatite C/tratamento farmacológico; Interferon/uso terapêutico; Drogas antivirais de ação direta

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“…In addition to the study of genetic susceptibility, virus infection is also an important research hotspot [23,[41][42][43][44][45][46]. In addition, some scholars believe that viral infection may be an important cause of VKHD.…”

Section: Focus On Vkhd Researchmentioning

confidence: 99%

“…In addition, some scholars believe that viral infection may be an important cause of VKHD. The clinical samples involved in the study included cerebrospinal uid aqueous humor and serum, and the types of viruses tested included herpes simplex virus (HSV), herpes zoster virus (VZV), Cytomegalovirus (CMV), and Epstein-Barr virus (EBV) and human herpes virus type 6 (HHV-6) [23,[41][42][43]. The trend of research related to viral infection has declined in the past ve years, but it is worth noting that many clinical studies and case reports have found VKHD associated with COVID-19 in the past three years as well as with the COVID-19 vaccine [45][46][47][48][49][50][51][52].…”

Section: Focus On Vkhd Researchmentioning

confidence: 99%

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

Liu

Zhou

et al. 2023

Preprint

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Background: As an autoimmune disease, Vogt‒Koyanagi‒Harada disease (VKHD) is one of the main types of uveitis in many countries and regions significantly impacting patent’s vision. At present, information regarding VKHD is still limited, and further research is needed. We conducted a bibliometric analysis to characterize the overall status, current trends, and current focus of VKHD research. Methods: Literature published from 1975 to 2022 was obtained from the Web of Science core collection and analyzed by the R-language packages Bibliometrix, VOSviewer, and CiteSpace software. Results: A total of 1050 papers on VKHD were retrieved from 261 journals and 16,084 references were obtained from the papers in the original search. The average annual number of published articles is approximately 21.9, and the number of publications rapidly increased after 2004. Ocular Immunology and Inflammation is the journal that published the most papers on VKHD, while the American Journal of Ophthalmology has the highest cited frequency. The leading countries were Japan, China (PRC), and the United States of America (USA). Yang PZ. from Chongqing Medical University is the most prolific and cited author. The most frequently cited literature is the literature on the revision of VKHD diagnostic criteria. An analysis of high-frequency keywords showed that the research focused on the treatment, diagnosis, and pathogenesis of VKHD and its relationship with other related diseases. At present, the urgent research direction is the relationship and specific mechanism between COVID-19 or COVID-19 vaccines and VKHD. Conclusion: Bibliometrics can clearly show the research history, development trends, and research hotspots of VKHD through dynamic and visualization tools. It is an efficient way to study the literature and is helpful for future researchers.

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Vogt–Koyanagi–Harada disease occurring during interferon-alpha and ribavirin therapy for chronic hepatitis C virus infection

Cited by 15 publications

References 8 publications

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

O olho na hepatite C: uma revisão

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

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