Vitrectomy Combined With Periocular/Intravitreal Injection of Steroids for Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Wei, Yubin; Wang, Ke; Chen, Fenghua; Wang, Huaizhou; Bi, Chuncao; Zu, Zhongqiao; Yang, Xingguang

doi:10.1097/iae.0b013e3182923463

Cited by 29 publications

(33 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Most studies have focused on the treatment of RRDCD, and the underlying etiology and pathogenesis of RRDCD have not been elucidated because of its poor prognosis. 6 Hypotony may be the most important factor in the pathogenesis of RRDCD. 7,8 The vitreous humor enters into the subretina via a retinal tear, which may lead to hypotony.…”

mentioning

confidence: 99%

Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Min

Zhang

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Min

Zhang

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…A recent retrospective study showed that both systemic steroids and periocular steroids were equally effective in management of RRD/CD in aspect of anatomical reattachment (Wei et al. ). The current study is of prospective nature and conducted a careful OCT follow‐up of reattached macula; less oedematous changes of macula was noted for subtenon TA group at both postoperative 1‐ and 3‐month.…”

Section: Discussionmentioning

confidence: 99%

“…; Wei et al. ). Systemic steroids can reduce CD associated inflammation and stabilize retina–blood barrier for better controlled surgery and better surgical results.…”

Section: Introductionmentioning

confidence: 98%

Perioperative pharmacological management of choroidal detachment associated with rhegmatogenous retinal detachment

Shen

Mao

Sun

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To compare subtenon triamcinolone versus systemic dexamethasone for perisurgical management of primary rhegmatogenous retinal detachment presenting with a choroidal detachment (RRD/CD). Methods: Thirty consecutive primary RRD/CD patients were prospectively studied. Sixteen RRD/CD patients were injected with a 40 mg subtenon triamcinolone acetonide (TA) 5 days before a scheduled vitrectomy (TA group) while the other 14 RRD/CD patients were intravenously infused daily with 10 mg dexamethasone (Dex) for 5 days before a scheduled vitrectomy (Dex group). All patients were followed up for 6 months. Changes of choroid detachment on B ultrasonography and preoperative intraocular pressure (IOP), systemic and ocular steroid level, blood sugar, and postoperative macular oedema were compared between the two groups. Results: During 5 days of presurgical treatment, the IOP recovery from the baseline was 3.29 AE 4.56 mmHg for the TA group versus 1.16 AE 1.60 mmHg for the Dex group (p = 0.021). The height of CD decreased significantly more for the TA group (3.55 AE 1.33 versus 1.84 AE 1.5 mm, p = 0.0029). The physiological cortisol level in the plasma was significantly suppressed for the Dex group (8.35 AE 10.35 versus 51.9 AE 35.9 ng/ml, p = 0.01). Postoperative 1-month macula was less oedematous for TA group (401 AE 196 versus 256 AE 66 lm, p = 0.0498). Conclusion: Subtenon TA seems to be a better option for perisurgical management of RRD/CD patients than systemic steroid application. Subtenon TA is more convenient for patients and imposes much less stress to patients' hormones homeostasis. This is especially important for those who are suffering metabolic disorders and need vitrectomy surgery for repairing RRD/CD.

show abstract

“…It is generally accepted that rhegmatogenous retinal detachment (RRD), when complicated by choroidal detachment (CD), has an especially unfavorable prognosis [1][2][3], with clinically apparent intraocular inflammation being a feature of the disease [4,5]. RRD is a degenerative disease with clinical signs of retinal hypoxia, which even if uncomplicated, is associated with expression of inflammatory mediators in ocular tissues and fluids [6].…”

Section: Introductionmentioning

confidence: 99%

Comparing bioelectrical activity of the peripheral retina among myopic patients operated for rhegmatogenous retinal detachment complicated by choroidal detachment

Yassine¹,

Ponomarchuk²,

Levytska³

et al. 2018

Oftalmol Zh

View full text Add to dashboard Cite

High myopia is known to be a major risk factor for the development of choroidal detachment (CD) in eyes with rhegmatogenous retinal detachment (RRD). Trophic disturbances of the retina in axial myopia have been previously confirmed by electroretinography (ERG) data, and are likely to play an important role in the pathogenesis of RRD complicated by CD. To the best of our knowledge, no study has examined in detail the ERG in myopic patients operated for RRD combined with CD. Purpose: 1) To investigate the bioelectrical activity of the peripheral retina after successful surgery for combined RRD and CD in patients differing in the degree of myopia, and 2) to compare the characteristics with those of normal eyes and myopic patients successfully operated for uncomplicated RRD. Materials and Methods: Fifty two patients (52 eyes) were included into the study 3 months after undergoing a single successful vitrectomy with gas tamponade, either for uncomplicated RRD (32 eyes), or combined RRD and CD (20 eyes). They were divided into four groups: Groups 1 and 2 (moderate and high myopes after surgery for uncomplicated RRD; 21 and 11 patients, respectively), and Groups 3 and 4 (moderate and high myopes after surgery for combined RRD and CD; 9 and 11 patients, respectively). Fourteen age-matched individuals (28 eyes) without any ocular or systemic disease were enrolled as controls (Group 5). Scotopic rod response, scotopic combined rod-cone response, and scotopic oscillatory potentials (OPs) were recorded to examine the bioelectrical activity of the peripheral retina. Results: The b-wave amplitude of scotopic rod-mediated response (the summed response of the midperipheral retinal layers to a weak flash arising from the rods in the dark-adapted eye) in myopic eyes in Groups 3 and 4 was 12-fold lower than in normal eyes, 4.3-to 8.8-fold lower than in the fellow eye, and 2.9-to 8.4-fold lower than in myopic eyes in Groups 1 and 2. In addition, the a-wave amplitude (the response of the peripheral retinal photoreceptors) in myopic eyes in Groups 1 and 3 was 1.8-fold lower than in normal eyes, and in highly myopic eyes, 3.4-fold lower than in normal eyes. The b-wave amplitude of scotopic combined rod-cone response (representing the activity of the midperipheral retinal layers) in Groups 3 and 4 was 2.5-fold and 7.5-fold lower, respectively, than in normal eyes, and 1.5-fold and 4.4-fold lower, respectively, than in the fellow eye, and 1.87-fold lower than in myopic eyes in Groups 1 and 2. The OP amplitude in myopic eyes in Groups 3 and 4 was 8.2-fold lower than in normal eyes, 4-fold lower than in the fellow eye, and 2.6-to 5.5-fold lower than in myopic eyes myopic eyes in Groups 1 and 2. The b-wave implicit time of scotopic combined rod-cone response in myopic eyes in Groups 1 to 4 was 19.9% (p < 0.05) longer than in normal eyes. In addition, myopic eyes in Groups 1 to 4 had similar a-wave implicit time compared with normal eyes. We found direct correlations between BCVA and b-wave and a-wave amplitudes of the scotopic rod-mediated ...

show abstract

Vitrectomy Combined With Periocular/Intravitreal Injection of Steroids for Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Cited by 29 publications

References 30 publications

Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Metabolomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment Associated With Choroidal Detachment

Perioperative pharmacological management of choroidal detachment associated with rhegmatogenous retinal detachment

Comparing bioelectrical activity of the peripheral retina among myopic patients operated for rhegmatogenous retinal detachment complicated by choroidal detachment

Contact Info

Product

Resources

About