Abstract:Vitiligo is a chronic stigmatizing disease, already known for millennia, which
mainly affects melanocytes from epidermis basal layer, leading to the
development of hypochromic and achromic patches. Its estimated prevalence is
0.5% worldwide. The involvement of genetic factors controlling susceptibility to
vitiligo has been studied over the last decades, and results of previous studies
present vitiligo as a complex, multifactorial and polygenic disease. In this
context, a few genes, including DDR1, XBP1 and NLR… Show more
“…It has its onset mostly during the 2nd and 3rd decade of life and affects females with a slight predilection over males. Although found globally, vitiligo tends to be more frequent among Asians and Africans (Tarle, Nascimento, Mira, & Castro, 2014;Zhang et al, 2016). In Mexico, a multicentre survey with 50,000 individuals estimated the prevalence to be 0.21% (Estrada Castañón et al, 1992), but data for South America are relatively sparse.…”
Section: Prevalence Of Vitiligo In Brazil-a Population Surveymentioning
“…It has its onset mostly during the 2nd and 3rd decade of life and affects females with a slight predilection over males. Although found globally, vitiligo tends to be more frequent among Asians and Africans (Tarle, Nascimento, Mira, & Castro, 2014;Zhang et al, 2016). In Mexico, a multicentre survey with 50,000 individuals estimated the prevalence to be 0.21% (Estrada Castañón et al, 1992), but data for South America are relatively sparse.…”
Section: Prevalence Of Vitiligo In Brazil-a Population Surveymentioning
“…31,32 The leading theory is that generalized vitiligo is a multifactorial, polygenic autoimmune disorder that occurs in only a minority of genetically susceptible individuals and is therefore believed to have a strong component of environmental triggering. Other theories of vitiligo development include biochemical defects in the tetrahydrobiopterin pathway/oxidative damage, adhesion defects, and neural induction 33 ; however, generalized disease at this point in time is usually presumed autoimmune in nature, with demonstrable autoantibodies against pigment cells in patients with vitiligo. 34 In a survey of 2624 primarily White probands, frequency was 6.1% in siblings, and concordance only 23% in identical twins.…”
Section: Pathophysiology and Genetic Determinantsmentioning
Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.
“…Vitiligo is a social stigma and is associated
with a decreased quality of life, especially when lesions are located over the face;
thus, it may affect the quality of social and personal life depending on the
patient's perception. 2 …”
BACKGROUNDVitiligo is an acquired pigmentary skin disorder that affects 0.5% to 2.0% of
the population.OBJECTIVEPatients' knowledge, opinions, and attitudes about vitiligo were
evaluated.METHODSThe team conducted a cross-sectional, descriptive, prospective study between
June 2014 and May 2015. The study included 100 patients aged over 12 years
who were diagnosed with vitiligo. A questionnaire including items on
knowledge, opinions, and beliefs about vitiligo and the Illness Perception
Questionnaire (IPQ) were filled out by the patients, and the results were
analyzed.RESULTSIn total, 100 (58 female, 42 male) patients were included in the study. Of
them, 74% knew the name of their disease, 90% thought that vitiligo was not
contagious, 48% reported that they obtained information on the disease from
a doctor, and 69% believed they had adequate information on vitiligo. Eighty
percent reported no negative effects from vitiligo on relationships with
friends or family. It was believed that stress, excessive sun exposure, and
heredity were causes of vitiligo, according to 84%, 37%, and 22% of the
patients, respectively. Thirty-six patients (36%) believed that their
illness was a serious disease and 35% deemed that it did not have a major
impact on their lives.CONCLUSIONSOur results show that vitiligo patients were generally highly aware of their
condition. The disease did not negatively affect patient opinions or
attitudes about vitiligo. The authors believe that improving
patient-physician communication will impact positively on the course of the
disease.
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