Vitiligo‐A Retrospect

Nair, B. K. H.

doi:10.1111/ijd.1978.17.9.755

Cited by 40 publications

(21 citation statements)

References 3 publications

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“…[6] The Ebers Papyrus in 1550 BC mentioned two forms of depigmentation that could be interpreted as leprosy or depigmentation resembling vitiligo. [7] By 1400 BC white leprosy spots were called Sveta khushtha in the Atharva Veda[8] and in 1200 BC Japanese Shinto prayers described depigmentation in the Amarakosa. [57] Around 600 BC, the Ashtanaga hridaya explained prognostic factors of depigmentation.…”

Section: Historical Aspectsmentioning

confidence: 99%

Vitiligo and the melanocyte reservoir

Falabella

2009

Indian J Dermatol

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Repigmentation of vitiligo depends on available melanocytes from three possible sources: from the hair follicle unit which is the main provider of pigment cells, from the border of vitiligo lesions, and from unaffected melanocytes within depigmented areas; pigment cells at these locations originate a perifollicular, border spreading and a diffuse repigmentation pattern. In order for repigmentation to take place under stimulation with diverse therapies, melanocytes should be present in appropriate numbers. Melanocyte tissue stem cells located in the niche at the bulge region of the hair follicle are the most important sources for providing immature pigment cells that undergo terminal differentiation and originate repigmentation, but cytokines, UVR and other molecules acting in melanogenesis with adequate regulation mechanisms contribute to successful recovery in vitiligo. The presence of keratinocyte stem cells in the interfollicular epidermis raises the question on the possibility of melanocyte stem cells in a similar location and the development of future strategies for therapeutic purposes.

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Section: Historical Aspectsmentioning

confidence: 99%

Vitiligo and the melanocyte reservoir

Falabella

2009

Indian J Dermatol

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“…Others believe that the actual word was first used by Celsus in his tome De Medicina in the first century A.D.[467]…”

Section: Historical Perspectivementioning

confidence: 99%

Evolution and evaluation of autologous mini punch grafting in vitiligo

Lahiri

2009

Indian J Dermatol

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Vitiligo is a result of disrupted epidermal melanization with an undecided etiology and incompletely understood pathogenesis. Various treatment options have resulted in various degrees of success. Various surgical modalities and transplantation techniques have evolved during the last few decades. Of them, miniature punch grafting (PG) has established its place as the easiest, fastest, and least expensive method. Various aspects of this particular procedure have been discussed here. The historical perspective, the instruments, evolution of mini grafting down the ages, and the methodology, advantages, and disadvantages have been discussed. A detailed discussion on the topic along with a review of relevant literature has been provided in this article.

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“…1 Vitiligo has been reported since ancient times and a description of it exists in the Latin medical classic De Medicina of Celsus during the second century. 2,3 The name might come from the Latin "vitium, " meaning defect or blemish. 4 Although vitiligo is not a rare disease, it has been until recently an orphan disease in terms of drug development and a neglected one in the field of dermatology.…”

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confidence: 99%

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

Ezzedine

Silverberg

2016

Pediatrics

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Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.

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Vitiligo‐A Retrospect

Cited by 40 publications

References 3 publications

Vitiligo and the melanocyte reservoir

Vitiligo and the melanocyte reservoir

Evolution and evaluation of autologous mini punch grafting in vitiligo

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children

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