SUMMARY Five cases of reactive perforating collagenosis (RPC) are reported. Four of these cases were in a father and his three children. This is the first reported instance of RPC occurring in more than one generation. The clinical and histological features of the disease are described and compared with other disorders showing perforating skin lesions, such as Kyrle's disease, perforating folliculitis and elastosis perforans serpiginosa. Evidence is presented to show that RPC is a genetically determined disorder with an inherited predisposition to an unusual skin reaction to superficial trauma.

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A comparative clinical evaluation of desoximetasone, a corticosterone derivative by a double blind study showed that desoximetasone has potent topical activity as effective as betamethasone valerate and probably more effective than triamcinolone acetonide.

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