Vitex agnus castus L.,—traditional drug and actual indications

Odenthal, K.P.

doi:10.1002/(sici)1099-1573(1998)12:1+<s160::aid-ptr283>3.0.co;2-y

Cited by 22 publications

(14 citation statements)

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“…Previous investigations suggested that the fruits of V. agnus-castus (VAC) contain a mixture of iridoids and flavonoids, and some compounds isolated from the leaves and flowers were found to be similar in chemical structure to human sex hormones (Wuttke 1996;Wuttke et al 2003). The seeds of this plant also contain phenolic compounds, terpens, flavonoids and aetheric oils (Odenthal 1998).…”

Section: Discussionmentioning

confidence: 99%

“…The violet flowers, the shrub and its fruits are often mentioned in ancient literature in relation to different cultural usages (Bohnert and Hahn 1990). Nowadays, preparations of different parts of the plant are used in complementary medicine for indications spanning from the treatment of male impotence to female cycle disorders (Odenthal 1998;Baytop 1999). Hobbs (1996) reported that (1) V. agnus-castus is an effective remedy for emmeniopathy, including amenorrhea, oligomenorrhea, and menorrhea; (2) through estrogen hypersecretion before menstruation in premenstrual tension, long-term use of V. agnus-castus reduced those symptoms and prevented relapse of the disease; and (3) the function of the corpus luteum deficiency syndrome improved with V. agnus-castus due to the crinogenic effect of luteinizing hormone.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the seeds of this plant contain phenolic compounds: terpens, flavonoids and aetheric oils (Odenthal 1998). Hirobe et al (1997) previously reported an anti-tumor effect of the extract of ripened Israeli-grown V. agnus-castus fruits on the Chinese hamster lung carcinoma cells line V-79.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant activity and anticancer effect ofVitex agnus-castusL. (Verbenaceae) seed extracts on MCF–7 breast cancer cells

Aslantürk

Çelik

2013

Caryologia

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Aim: The aim of this study was to investigate the in vitro antioxidant and anticancer activities of diethyl ether, petroleum ether, ethyl acetate, methanol and water (infusion and decoction) extracts from Vitex agnus-castus L. (Verbenaceae) seeds. Materials and methods: Antioxidant activities of crude extracts from V. agnus-castus L. seeds were evaluated by 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) scavenging assay, and anticancer activity of the extracts on MCF-7 breast cancer cells of extracts were evaluated by determining cytotoxic, DNA damaging and apoptotic activities with trypan blue exclusion assay, comet assay and Hoechst 33258/propidium iodide double staining. Results: Although V. agnus-castus L. methanol and water (infusion and decoction) extracts showed significant DPPH scavenging activity, diethyl ether, petroleum ether and ethyl acetate extracts have low DPPH scavenging activity. However, all of the extracts showed a significant cytotoxic, DNA damaging and apoptotic effects in MCF-7 human breast cancer cells. Cytotoxic, DNA damaging and apoptotic activities of the extracts increased in concentration dependent manner. Conclusion: Our results suggest crude extracts of V. agnus-castus seeds have potent antioxidant, cytotoxic and apoptotic activity. Further investigations are required for the isolation and identification of individual phenolic compounds in the extracts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant activity and anticancer effect ofVitex agnus-castusL. (Verbenaceae) seed extracts on MCF–7 breast cancer cells

Aslantürk

Çelik

2013

Caryologia

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“…6 Studies reported that the fruit of this plant contains phenolic compounds like terpenes, flavonoids and aetheric oils, etc. 7 Further studies on it showed that ethanolic extract from dried ripe VAC fruits displays cytotoxic activity against six human cell lines from different cancer tissue origins. 8 Studies for antioxidant activity in the past have shown that decreased GSH levels are indicator of cell viability along-with increased MDA levels showing marked cell proliferation in tumor tissues whereas decreased levels of the same are indicator improved oxidative status of the tissue.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitex agnus Extract on MNU Induced Mammary Tumor of Sprague Dawley Rats

Kour¹,

Anantharaya

Bhat³

et al. 2017

JYP

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INTRODUCTIONBreast cancer is one of the most common cancers with over one million cases reported worldwide. It accounts up to 30% of all the cancers reported in female's worldwide. 1 Regardless of having advanced treatments, the disease continues to have the highest rate of treatment failure due to tumor resistance, both intrinsic and acquired.2 Many treatment strategies have been applied for the best results to ameliorate the cancer, but none has shown any significant results so far. Natural products have long been an important source for the treatment of different types of cancer. More than a thousand plants have been found to possess significant anticancer properties.3 Over 60% of currently used anticancer agents are derived from natural sources. 4 The Vitex agnus castus (VAC) is a shrub found in central Europe and central Asia has brown or black colored pepper like seeds having significant levels of herbal and medicinal properties.5 It is a well-known herb used for the treatment of female reproductive problem, especially pre-menstrual syndrome and certain endocrine related problems. 6 Studies reported that the fruit of this plant contains phenolic compounds like terpenes, flavonoids and aetheric oils, etc.7 Further studies on it showed that ethanolic extract from dried ripe VAC fruits displays cytotoxic activity against six human cell lines from different cancer tissue origins.8 Studies for antioxidant activity in the past have shown that decreased GSH levels are indicator of cell viability along-with increased MDA levels showing marked cell proliferation in tumor tissues whereas decreased levels of the same are indicator improved oxidative status of the tissue. From the recent literature, it is evident that ethanolic fruit extract of the VAC has shown some anticancer effects in, in-vitro studies and there is no recent data suggesting the anticancer property in vivo. Therefore, this study was conducted to elucidate the anticancer effect of the Vitex agnus seed extract along-with its antioxidant activity by estimating GSH and MDA levels on induced mammary tumor of SD rats in an in-vivo study. MATERIALS AND METHODS AnimalsAfter obtaining the permission from the institutional ethical committee, healthy, 30 days old inbred Sprague Dawley female rats of body weight 70-80 grams were taken for this study. Animals were maintained according to prescribed guidelines of a committee for control and supervision of experts on animals (CPCSEA), Govt. Of India, for the use of laboratory animals. All animals were maintained under normal day-night environment in temperature controlled institutional animal house. Animals were housed in polypropylene cages; paddy husk was used for bedding. Animals were given water ad libitum and standard rat feed pellet was used for feeding. Induction of tumor Preparation of the carcinogenMammary tumor was induced by injecting N-Methyl-N-Nitrosourea dissolved in normal saline with pH-4 maintained by adding 3% glacial acetic acid. The SD rats were given a single intraperitoneal dose of Effect o...

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“…It is also cultivated in the various regions including the United States [4]. The fruits of V. agnus-castus are popularly used as a phytomedicine in Europe for the treatment of female hormonal disorders [5–7]. The fruit extract is also used as an alternative phytotherapeutic agent in the treatment of mastalgia [8].…”

Section: Introductionmentioning

confidence: 99%

Compounds from the Fruits of the Popular European Medicinal PlantVitex agnus-castusin Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction

Qiu

Yao

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer chemoprevention. Chemically, the nitrogenous isolates were found to be two labdane diterpene alkaloids, each containing an α, β-unsaturated γ-lactam moiety. Structurally, they were elucidated to be 9α-hydroxy-13(14)-labden-16,15-amide (2) and 6β-acetoxy-9α-hydroxy-13(14)-labden-15,16-amide (3), which were named vitexlactams B and C, respectively. The 15 known isolates were identified as vitexilactone (4), rotundifuran (5), 8-epi-manoyl oxide (6), vitetrifolin D (7), spathulenol (8), cis-dihydro-dehydro-diconiferylalcohol-9-O-β-D-glucoside (9), luteolin-7-O-glucoside (10), 5-hydroxy-3,6,7,4′-tetramethoxyflavone (11), casticin (12), artemetin (13), aucubin (14), agnuside (15), β-sitosterol (16), p-hydroxybenzoic acid (17), and p-hydroxybenzoic acid glucose ester (18). All compound structures were determined/identified on the basis of 1D and/or 2D NMR and mass spectrometry techniques. Compounds 6, 8, 9, and 18 were reported from a Vitex spieces for the first time. The cancer chemopreventive potentials of these isolates were evaluated for NADP(H):quinone oxidoreductase type 1 (QR1) induction activity. Compound 7 demonstrated promising QR1 induction effect, while the new compound vitexlactam (3) was only slightly active.

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Vitex agnus castus L.,—traditional drug and actual indications

Cited by 22 publications

References 0 publications

Antioxidant activity and anticancer effect ofVitex agnus-castusL. (Verbenaceae) seed extracts on MCF–7 breast cancer cells

Antioxidant activity and anticancer effect ofVitex agnus-castusL. (Verbenaceae) seed extracts on MCF–7 breast cancer cells

Effect of Vitex agnus Extract on MNU Induced Mammary Tumor of Sprague Dawley Rats

Compounds from the Fruits of the Popular European Medicinal PlantVitex agnus-castusin Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction

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