Vitamins and Regulation of Gene Expression

Azzi, Angelo; Aratri, Elisabetta; Boscoboinik, Daniel; ́ment, S. Cle; ̈zer, N. O; Ricciarelli, Roberta; Spycher, Stefan; Stocker, Achim

doi:10.1159/000059476

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Mostly all vitamins are involved in gene expression. (74) Vitamin C and Vitamin E are helpful in prevention of oxidation to DNA and lipid oxidation while its deficiency is associated with increased baseline level of DNA strand breaks, chromosome breaks, and oxidative DNA lesions and lipid peroxide adducts on DNA. (75) Folate and vitamin B12 play major roles in maintenance and methylation of DNA synthesis of dTMP from dUMP and efficient recycling of folate but in deficient condition, uracil misincorporation in DNA, increased chromosome breaks and DNA hypomethylation occur.…”

Section: Effect Of Vitamins On Gene Expressionmentioning

confidence: 99%

Nutrigenomics: Nutrient-Gene Interactions

Siddique¹,

Tandon²,

Ambwani³

et al. 2009

Food Reviews International

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Nutritional research has recently emphasized the role of nutrients on gene expression and regulation. Although not as broadly appreciated, availability of nutrients affects gene expression. The response to a nutrient status seems in many cases to be specific for each genotype and specific nutrient impairment results in altered gene expression, depending on each genotype. Recent literature has suggested that carbohydrates, fatty acids, minerals, and vitamins of all the dietary constituents participate in the regulation of gene expression. Here, we summarize the current knowledge on the role of nutrients on cancer, phenylketonuria, cardiovascular and other life threatening diseases.

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Section: Effect Of Vitamins On Gene Expressionmentioning

confidence: 99%

Nutrigenomics: Nutrient-Gene Interactions

Siddique¹,

Tandon²,

Ambwani³

et al. 2009

Food Reviews International

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Nutrients and Gene Expression

Caterina

Madonna

Hassan

et al. 2004

Nutrigenetics and Nutrigenomics

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Role of Nutrients and Physical Activity in Gene Expression

Caterina

Madonna²

2005

World Review of Nutrition and Dietetics

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In prokaryotes and lower eukaryotes, the regulation of gene expression in response to changes in nutrients is common and well-documented [1]. In multicellular organisms, nutrients are effectors of more complex functions, such as the stimulation of hormone synthesis and the secretion of neurotransmitters. Nutrients such as fatty acids and their metabolites [2], monosaccharides [3], amino acids [4], nucleotides [5], and vitamins [6] regulate gene expression by interacting directly with transcription factors controlling the expression of specific genes through cis-regulatory elements in the promoter region or altering the stability of messenger(m)RNA.We recently reviewed several examples of regulation of gene expression by micro-and macro-nutrients [7,8]. We herein expand on the issue of the regulation of gene expression by nutrients during physical activity, and summarize recent insights from our own research into regulation of gene expression by polyunsaturated fatty acids. Finally we will here highlight how the intake of specific nutrients may condition the expression of a specific genotype, an example of the expanding interest in the area of nutrigenetics. Nutrients, Physical Activity and Gene ExpressionThe skeletal muscle has a major impact on whole-body metabolic homeostasis, being capable of remarkable adaptation in response to exercise and dietary intervention. Transcriptional activation and increased mRNA stability are the main mechanisms by which exercise increases the expression of many genes in skeletal muscle. Nutrient availability and associated alterations of hormone levels are additional modifiers of skeletal muscle gene expression.

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Vitamins and Regulation of Gene Expression

Cited by 4 publications

References 16 publications

Nutrigenomics: Nutrient-Gene Interactions

Nutrigenomics: Nutrient-Gene Interactions

Nutrients and Gene Expression

Role of Nutrients and Physical Activity in Gene Expression

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