Nutrigenomics: Nutrient-Gene Interactions

Siddique, R. A.; Tandon, Mayank; Ambwani, Tanuj Kumar; Rai, S. N.; Atreja, S. K.

doi:10.1080/87559120903155883

Cited by 7 publications

(4 citation statements)

References 97 publications

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“…Nutrients behave as transcription factors after interacting with a receptor, which binds tightly to DNA and intensely induces gene expression. For instance, as in the case of lac operon, which is by default turned off if lactose is not present in a cell (e.g., bacterial cell) (Siddique et al, 2009). The lacI inhibitor gene binds with promoter region and as a result will not allow RNA polymerase to transcribe, and hence no transcription of DNA takes place.…”

Section: Origin Of Nutrigenomicsmentioning

confidence: 99%

Nutrigenomics: linking food to genome

Jabeen

Malik²,

Mir³

et al. 2023

Ital. J. Food Sci.

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Nutrigenomics has an undoubtedly immeasurable potential for revamping human health. It has become an important regimen due to its consequential role in medical and nutritional sciences. It is an interdisciplinary science that amalgamates the information from physiology, pathology, genetics, molecular biology, and nutrition to establish the effects of ingested nutrients on expression and regulation of genes. The ultimate aim of nutrigenomics is to ascertain the nutritional requirement of an individual in accordance with genetic makeup. Moreover, it aims to purvey treatment in the management of certain ailments having a dietary role based on individual’s genomic profile. Therefore, vast research in the field of nutritional genomics is a dire need to make people aware regarding their health and diet relationship. Here, we have given an overview of nutrigenomics coupled with novel technologies to produce utilitarian information for health professionals and researchers by divulging certain properties that interfere with the genomic machinery.

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Section: Origin Of Nutrigenomicsmentioning

confidence: 99%

Nutrigenomics: linking food to genome

Jabeen

Malik²,

Mir³

et al. 2023

Ital. J. Food Sci.

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“…The nutrients in our body can interact with our genes. Fundamentally, the nutrient-gene interactions can occur in three ways and could potentially act as drivers of drug-food interactions (Table 6 ) [ 119 , 120 ].…”

Section: Personalized Wellness: Nutrigenomics and Nutrigeneticsmentioning

confidence: 99%

Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health

Roy

Marakkar

Vayalil

et al. 2022

RAFNA

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The drug-food interaction brings forth changes in the clinical effects of drugs. While favourable interactions bring positive clinical outcomes, unfavourable interactions may lead to toxicity. This article reviews the impact of food intake on drug-food interactions, the clinical effects of drugs, and the effect of drug-food in correlation with diet and precision medicine. Emerging areas in drug-food interactions are the food–genome interface (nutrigenomics) and nutrigenetics. Understanding the molecular basis of food ingredients, including genomic sequencing and pharmacological implications of food molecules, help to reduce the impact of drug-food interactions. Various strategies are being leveraged to alleviate drug-food interactions: measures including patient engagement, digital health, approaches involving machine intelligence, and big data are a few of them. Furthermore, delineating the molecular communications across diet-microbiome-drug-food-drug interactions in a pharmacomicrobiome framework may also play a vital role in personalized nutrition. Determining nutrient-gene interactions aids in making nutrition deeply personalized and helps mitigate unwanted drug-food interactions, chronic diseases, and adverse events from its onset. Translational bioinformatics approaches could play an essential role in the next generation of drug-food interaction research. In this landscape review, we discuss important tools, databases, and approaches along with key challenges and opportunities in drug-food interaction and its immediate impact on precision medicine.

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“…Accordingly, in a rapidly changing environment, it is suggested that the adaptation of a DNA sequence to specific changes is a slow process [28]. Thus, the flexibility for rapid adaptation to the environment is therefore facilitated by mechanisms that allow for the modification of a phenotype by epigenetic programming [28].…”

Section: Our Dynamic Genomementioning

confidence: 99%

“…Moreover, it has recently been demonstrated that the epigenome is highly dynamic and changes in response to aging, physical exercise, and nutrients for example [29,32]. Epigenetics is emerging as perhaps the most important mechanism whereby the diet and nutrients can directly affect the genome and thus the modulation of gene expression [28].…”

Section: Gene-nutrient Interactions: Epigenetic Programmingmentioning

confidence: 99%

Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past

Myers

Williamson²

2014

J Diabetes Metab 2013

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Contemporary humans are genetically adapted to the environment that their ancestors survived in and that consequently selected their genetic makeup. Since the agricultural revolution some 10,000 years ago, the lifestyles and dietary requirements of modern humans have changed dramatically. It is suggested that these changes have occurred too recently on an evolutionary time scale for the modern human genome to adapt. Therefore, our ancestral genome is ill-suited for our current modern consumption and existence, and thus contributes to diseases associated with contemporary lifestyles, such as cardiovascular disease, obesity and type 2 diabetes. It is therefore suggested that a diet similar to our ancestors could circumvent many of our modern illnesses and serve as a reference for better nutrition, health, and longevity. Although this model should certainly be commended for its simplistic dietary practices that no doubt improve health and well-being; its premise is cemented in the thrifty genome hypothesis and the fact that humans are modern hunters and gatherers whose genome is ill-suited for modern diets. This is a disjointed view of modern humans and our ability to evolve under different eco regions and nutritional pressures through post-genomic and post-transcriptional changes in our genome. Accordingly, a major challenge associated with nutritional research is to understand how these changes in our genome reflect on our nutrition habits and lifestyles to ameliorate many of our modern lifestyle diseases.

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Nutrigenomics: Nutrient-Gene Interactions

Cited by 7 publications

References 97 publications

Nutrigenomics: linking food to genome

Nutrigenomics: linking food to genome

Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health

Nutrition, Genes and Modern Disease: A Current Dilemma or a Legacy of our Past

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