Clitoria ternatea is a perennial herb of India which is reported to possess several therapeutic properties. It is also found in China, Philippines and Madagascar. It is a vigorous, persistent, herbaceous perennial legume. Most of the plant parts are reported to possess therapeutic properties. In the traditional system of medicine, Clitoria ternatea has been utilized for treatment of worm infestation, infertility, skin problems, tonsillitis, cough, asthma traditionally etc. In the present study, fifty percent hydromethanolic extract of leaf of Clitoria ternatea (CTE) was prepared and subjected to various biochemical qualitative tests and GC-MS analysis to detect the presence of various phytoconstituents in CTE. Biochemical tests confirmed the presence of various phytochemicals viz., saponins, resins, tannins, flavonoids, alkaloids, glycosides, etc. GC-MS analysis revealed the occurrence of thirty compounds in CTE. The main phyto-composition of Clitoria ternatea is predicted to be Butyl-2-methyl-propylphthalate (20.11%), Butyl-2-methylpropylphthalate (10.39%), Butylocty-lphthalate (11.29%), Diisononylphthalate (3.54%) etc., whereas, Butyl-2-ethyl-hexyl-phthalate was major phytoconstituents with 30.19% of total constituents. Thus it could be inferred that the therapeutic potential of CTE is because of different phytochemicals present in the extract prepared.
Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phytoformulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using -Nano Delivery Systems‖ (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient's compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for
Nutritional research has recently emphasized the role of nutrients on gene expression and regulation. Although not as broadly appreciated, availability of nutrients affects gene expression. The response to a nutrient status seems in many cases to be specific for each genotype and specific nutrient impairment results in altered gene expression, depending on each genotype. Recent literature has suggested that carbohydrates, fatty acids, minerals, and vitamins of all the dietary constituents participate in the regulation of gene expression. Here, we summarize the current knowledge on the role of nutrients on cancer, phenylketonuria, cardiovascular and other life threatening diseases.
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