Vitamin status in morbidly obese patients: a cross-sectional study

Aasheim, Erlend T.; Hofsø, Dag; Hjelmesæth, Jøran; Birkeland, Kåre I.; Bøhmer, Thomas

doi:10.1093/ajcn/87.2.362

Cited by 273 publications

(242 citation statements)

References 45 publications

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“…It is well established that obesity is associated with vitamin D insufficiency. Our data confirm previous reports showing a high prevalence of vitamin D insufficiency in morbidly obese subjects (Carlin et al, 2006;Aasheim et al, 2008;Goldner et al, 2008;Lagunova et al, 2009). Our study has demonstrated that men had higher odds of vitamin D deficiency even after adjustment for the confounders season, age, current smoking and vitamin D supplements (model 2).…”

Section: Discussionsupporting

confidence: 91%

“…Women have relatively more body fat than men and store more fat in the gluteal-femoral region, while men typically store more fat in the visceral (abdominal) depot (Blaak, 2001;Hofso et al, 2009a). Some studies have found a higher prevalence of vitamin D deficiency among men than women (Aasheim et al, 2008;Lagunova et al, 2009). As vitamin D is a fat soluble vitamin that may potentially be sequestrated in adipose tissue (Wortsman et al, 2000), one could hypothesize that a gender difference in the prevalence of vitamin D deficiency is related to differences in the amount of body fat and/or its distribution.…”

Section: Introductionmentioning

confidence: 99%

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Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study

et al. 2011

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study

et al. 2011

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“…The observation that obesity is associated with below-normal serum 25-hydroxyvitamin D concentrations and/or overt deficiency is not new; however, as obesity prevalence has grown, so have the number of reports in the literature regarding this phenomenon. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Some of the most recent information about low vitamin D status and obesity comes from studies in bariatric surgery patients, reporting low preoperative circulating levels of 25-hydroxyvitamin D. [21][22][23][24][25][26][27][33][34][35][36][37][38] In fact, a recent systematic review of 14 studies with about 1500 patients undergoing bariatric surgical procedures confirmed that obese individuals have serum 25-hydroxyvitamin D levels below 80 nmol l À1 preoperatively. 39 Other investigators have reported that body mass index (BMI) 25,26,[40][41][42][43][44][45][46] and body fat 20,45,…”

Section: Methodsmentioning

confidence: 99%

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

et al. 2011

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Obesity and vitamin D deficiency have both been recognized as major public health issues worldwide, and there is growing evidence that they are related, although the cause-effect relationship remains unclear. Could obesity be contributing to low circulating 25-hydroxyvitamin D concentrations? Alternatively, could low vitamin D status predispose to obesity? In this review, the relationship between low circulating 25-hydroxyvitamin D and obesity, and possible underlying reasons from both perspectives, is presented. One potential mechanism by which obesity could contribute to low serum 25-hydroxyvitamin D is adipose sequestration of vitamin D. On the other hand, adipose tissue has both the vitamin D receptor and the ability to synthesize 1,25-dihydroxyvitamin D, and there is evidence that vitamin D may regulate adipose tissue mass, differentiation and metabolism in ways that might contribute to obesity. Of particular interest, vitamin D deficiency is common both before and after bariatric surgery, and is often difficult to treat, particularly with the more malabsorptive procedures. Additional research is needed to elucidate the complex and multifaceted factors underlying the association between low circulating 25-hydroxyvitamin D and obesity, and to identify optimal treatment approaches in obese individuals and in bariatric surgical patients both before and after surgery.

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“…One of these factors is body-mass index (BMI) that has been suggested to be negatively correlated with plasma/serum folate, although the findings are controversial [2][3][4][5][6][7][8][9][10][11][12][13][14]. For erythrocyte folate, another commonly used index of folate status, however, no such significant correlation are reported [4,5].…”

Section: Introductionmentioning

confidence: 99%

Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults

et al. 2011

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2 AbstractPurpose Plasma folate concentrations are suggested to be negatively associated with body-mass index (BMI, kg/m 2 ), although these findings are controversial. Our objective was to evaluate the association of BMI to blood folate and total homocysteine (tHcy) concentrations. MethodsWe measured plasma and erythrocyte folate and plasma tHcy concentrations in 434 healthy adults (343 women and 91 men; mean age of 63.8 ± 10.7 [SD, range 23-88] years old), who participated in a 2007 population-based survey in western Japan. ResultsThe overall mean plasma and erythrocyte folate and tHcy were 21.6 (± 11.0, SD) nmol/L, 844 (± 291) nmol/L and 11.6 (± 3.9) µmol/L, respectively. The mean BMI Mean plasma folate decreased as BMI increased (P-trend < 0.01), whereas mean erythrocyte folate and plasma tHcy were similar regardless of BMI (P-trends = 0.49 and 0.28, respectively). ConclusionOur data indicate that the interpretation of plasma folate concentrations to assess folate nutritional status is complicated by BMI, although the impact of BMI on plasma folate was relatively small. It is important to take this association into account for the selection of subjects for future large-scale studies. The mechanism of this inverse association between BMI and plasma folate concentrations should be investigated.

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Vitamin status in morbidly obese patients: a cross-sectional study

Abstract: Low concentrations of vitamin B-6, vitamin C, 25-hydroxyvitamin D, and vitamin E adjusted for lipids are prevalent in morbidly obese Norwegian patients seeking weight-loss treatment.

Cited by 273 publications

References 45 publications

Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study

Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study

The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications

Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults

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