Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults

Nakazato, Mio; Maeda, Takahiro; Takamura, Noboru; Wada, Mitsuhiro; Hironori, Yamasaki; Johnston, Kelley E.; Tamura, Tsunenobu

doi:10.1007/s00394-010-0165-0

Cited by 27 publications

(21 citation statements)

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“…Since only 4 students was classified as BMI ≥ 25 and had low serum folate concentrations, further studies are needed to confirm the association of BMI and serum folate concentrations. There were no significant associations between BMI and RBC folate concentrations in both male and female students and these results are consistent with previous studies [15,31]. Our data shows that the students who practiced physical activity for 30 min/day three times or more per week had higher folate intake and blood folate concentrations even after controlling for other health-related behaviors.…”

Section: Discussionsupporting

confidence: 91%

“…Higher BMI has been shown to be associated with lower serum folate concentrations in male and female adults [31], as well as in child-bearing age women [15]. Serum folate concentration in female students whose BMI is higher than 25 was significantly lower compared to those less than 25, but no association was found after controlling for other health-related behaviors.…”

Section: Discussionmentioning

confidence: 99%

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Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students

et al. 2013

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The purpose of this study is to assess folate intake, and serum and red blood cell (RBC) folate concentrations, and investigate the association between folate status and health-related behaviors among Korean college students. A total of 169 students, aged between 18 and 27 years, participated in this study. Dietary intake data were collected by trained interviewers using a 24-hour recall method for three non-consecutive days in 2009. Information on health-related behaviors was obtained by a self-administered questionnaire. Serum and RBC folate concentrations were measured by microbiological assay. The average intakes of folate were 456 µgDFE and 347 µgDFE in male and female students, respectively. While the average serum folate concentration was significantly lower in male students (8.9 ng/mL) compared to female students (12.5 ng/mL), RBC concentrations were not significantly different between male (398.6 ng/mL) and female students (405.3 ng/mL). In male students, low serum folate concentrations were associated with total folate intake less than the Estimated Average Requirement, non-use of folic acid supplements, smoking, alcohol drinking at least once a week and low physical activity. In female students, low serum folate concentrations were associated with smoking and alcohol drinking at least two drinks at a time and BMI ≥ 25. Alcohol drinking and low physical activity were also associated with low RBC folate concentrations in both male and female students. In order to improve folate nutritional status of college students, the practice of desirable health-related behaviors, such as non-smoking, moderate alcohol drinking, regular physical activity, and maintenance of healthy BMI should be encouraged along with consumption of folate-rich foods and supplements.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students

et al. 2013

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“…The positive effect of body weight on bone mass may be attributable to a number of factors: increased mechanical load which has an anabolic effect on bone [4]; conversion of steroid precursors to estrogen in peripheral adipose tissue [5] or through the secretion of bone active hormones from β-cells in the pancreas and adipocytes themselves [6]. Homocysteine (Hcy), vitamin B12, vitamin D and folate are biomarkers for a number of pathologies including cardiovascular disease and diabetes and a strong correlation between these biomarkers with BMI has been reported [7]–[10]. Elevated levels of Hcy and low levels of vitamin D are strong and independent risk factors for osteoporotic fracture risk [11], [12].…”

Section: Introductionmentioning

confidence: 99%

Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women

et al. 2014

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Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r2 = 0.2–0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs. CC: BUA: 100 vs. 103 vs. 103; p = 0.002); (SOS: 1521 vs. 1526 vs. 1524; p = 0.008); (Stiffness index: 69 vs. 73 vs. 74; p = 0.0006) after adjustment for confounders. They also had low folate (18 vs. 17 vs. 16; p = 0.03) and vitamin D (93 vs. 91 vs. 90; p = 0.03) and high Hcy levels (13.7 vs 14.4 vs. 14.5; p = 0.06). Fracture incidence was lower among women with the C-allele, (52% vs. 58%; p = 0.067). Variation in MC4R was not associated with BMD or body composition in either OPRA or PEAK-25. SNPs close to FTO and INSIG2 were not associated with any bone phenotypes in either cohort and FTO SNPs were only associated with body composition in PEAK-25 (p≤0.001). Our results suggest that genetic variation close to MC4R is associated with quantitative ultrasound and risk of fracture.

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“…In the present study, homocysteine was not associated with BMI among normal weight, overweight, or obese subjects, nor in the whole population after adjusting for cardiac medication use, or when looking exclusively at those without diabetes. Conflicting results between BMI and circulating homocysteine levels have been reported, and a recent study of men and women in Western Japan also showed no association between BMI and plasma homocysteine 31. In contrast, CRP and fibrinogen were positively associated with BMI in the overall population and among obese subjects, with strong positive associations additionally noted among overweight and normal weight subjects for CRP.…”

Section: Discussionmentioning

confidence: 85%

The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults

Costa¹,

Arora²,

García‐Bailo³

et al. 2012

DMSO

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IntroductionObesity is associated with a state of chronic inflammation, and increased cardiometabolic disease risk. The present study examined the relationship between body mass index (BMI) and cardiometabolic and inflammatory biomarkers among normal weight, overweight, and obese Canadian adults.MethodsSubjects (n = 1805, aged 18 to 79 years) from the Canadian Health Measures Survey (CHMS) were examined for associations between BMI, cardiometabolic markers (apolipoprotein [Apo] A1, ApoB, low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], total cholesterol, total cholesterol/HDL ratio [total:HDL-C ratio], triglycerides, and glycosylated hemoglobin [HbA1c]), inflammatory factors (C-reactive protein [CRP], fibrinogen, and homocysteine), and 25-hydroxyvitamin D [25(OH)D]. Bootstrap weights for variance and sampling weights for point estimates were applied to account for the complex survey design. Linear regression models adjusted for age, sex, physical activity, smoking status, and ethnicity (in addition to season of clinic visit, for vitamin D analyses only) were used to examine the association between cardiometabolic markers, inflammatory factors, and BMI in Canadian adults.ResultsAll biomarkers were significantly associated with BMI (P ≤ 0.001). ApoA1 (β = −0.31, P < 0.0001), HDL-C (β = −0.61, P < 0.0001), and 25(OH)D (β = −0.25, P < 0.0001) were inversely associated with BMI, while all other biomarkers showed positive linear associations. Distinct patterns of association were noted among normal weight, overweight, and obese groups, excluding CRP which showed a significant positive association with BMI in the overall population (β = 2.80, P < 0.0001) and in the normal weight (β = 3.20, P = 0.02), overweight (β = 3.53, P = 0.002), and obese (β = 2.22, P = 0.0002) groups.ConclusionsThere is an apparent profile of cardiometabolic and inflammatory biomarkers that emerges as BMI increases from normal weight to obesity. Understanding these profiles may permit developing an effective approach for early risk prediction for cardiometabolic disease.

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Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults

Cited by 27 publications

References 21 publications

Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students

Intake and blood concentrations of folate and their association with health-related behaviors in Korean college students

Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women

The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults

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