Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in Japan

Miyazawa, Kenji; Nishimaki, Jiroh; Ohyashiki, Kazuma; Enomoto, Soichi; Kuriya, S; Fukuda, Ryuki; Hotta, Tomomitsu; Teramura, Masanao; Mizoguchi, Hideaki; Uchiyama, Takashi; Omine, Mitsuhiro

doi:10.1038/sj.leu.2401790

Cited by 37 publications

(33 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Therefore, it is not so surprising that these vitamin K compounds show some anti-leukemic activity. However, unlike these anti-tumor reagents, VK2 has a much lower toxicity and does not induce bone marrow suppression, [13][14][15]30 which are important clinical benefits for the treatment of patients with MDS and AML. Considerable evidence shows that mitochondria play a central role in apoptosis (reviewed in Ref.…”

Section: Discussionmentioning

confidence: 99%

“…15 Improvement of cytopenias such as anemia and thrombocytopenia has also been reported in 20% of patients having RA, according to a retrospective clinical survey. 14 Since there were no adverse effects or bone marrow suppression, a differentiation inducing effect of VK2 on the MDS clone may be involved. 14 In addition, a combination of all-trans retinoic acid and VK2 succeeded in inducing complete hematological remission in a case of relapsed acute promyelocytic leukemia, probably because of the induction of leukemic cell differentiation.…”

Section: Leukemiamentioning

confidence: 99%

“…[13][14][15] In patients with MDS of refractory anemia of excess of blasts in transformation (RAEB-T) and post-MDS AML (a secondary AML arising from MDS), 16 VK2 has been reported to have an effect in the reduction of blast cell numbers and improvement of cytopenia without any adverse effects. 13,14 These data appear to be consistent with our in vitro observations showing that VK2 selectively induces apoptosis of blastic populations in the bone marrow cells of patients with refractory anemia of excess of blasts (RAEB), RAEB-T and AML. 17 However, VK2 therapy has also been reported to show the improvement of cytopenias in patients with refractory anemias (RA).…”

Section: Introductionmentioning

confidence: 99%

“…17 However, VK2 therapy has also been reported to show the improvement of cytopenias in patients with refractory anemias (RA). 14,15 This might be interpreted as either the differentiation-inducing effect or the elimination of the MDS clone by VK2 treatment.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells

et al. 2001

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Leukemiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells

et al. 2001

Self Cite

View full text Add to dashboard Cite

“…The importance of vitamin K in bone metabolism is further supported by studies showing that vitamin K inhibits osteoclastic bone resorption by induction of osteoclast apoptosis [13,14]. In addition to these biological activities, vitamin K 2 has been reported to induce apoptosis in hepatocellular carcinoma, leukaemia [15] and myelodysplastic syndrome cell lines [16].…”

Section: Introductionmentioning

confidence: 97%

Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients

Ahmed

Kishikawa

Ohyama

et al. 2011

Talanta

View full text Add to dashboard Cite

Vitamin K is a fat-soluble vitamin involved in blood coagulation and bone metabolism. The detection and monitoring of vitamin K homologues in rheumatoid arthritis (RA) patients is a challenging problem due to the smaller concentrations of vitamin K and the presence of several interfering medications. Therefore, this study aimed to develop a new highly sensitive and selective chemiluminescence (CL) method designated to quantify vitamin K homologues in plasma of RA patients selectively including phylloquinone (PK, vitamin K 1 ), menaquinone-4 (MK-4, vitamin K 2 ) and menaquinone-7 (MK-7, vitamin K 2 ). The method was based on the unique photochemical properties of vitamin K homologues that were exploited for selective luminol CL reaction. The correlation coefficients of 0.998 or more were obtained in the concentration ranges of 0.1-100 ng mL -1 vitamin K homologues. The detection limits were 0.03-0.1 ng mL -1 in human plasma for vitamin K homologues. The developed HPLC-CL system was successfully applied for selective determination of vitamin K homologues in plasma of RA patients. The developed method may provide a useful tool for monitoring vitamin K homologues in different clinical studies such as RA, osteoporosis and hepatocellular carcinoma in which vitamin K is intervented.

show abstract

Vitamin K and rheumatoid arthritis

Okamoto

2008

IUBMB Life

View full text Add to dashboard Cite

SummaryVitamin K2 [menaquinone-4 (MK-4)] has been reported to induce apoptosis in hepatocellular carcinoma, leukemia, and MDS cell lines. The effects of MK-4 on the development of arthritis have never been addressed so far. In this study, we investigated the effect of MK-4 upon the proliferation of rheumatoid synovial cells and the development of arthritis in collageninduced arthritis (CIA). We analyzed the effect of MK-4 on the proliferation of fibroblast-like synoviocytes (FLSs) using the 3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The proapoptotic effect of MK-4 upon FLS was investigated with annexin V staining and DNA fragmentation and caspase 3/7 assays. Moreover, we analyzed the effect of MK-4 on the development of CIA in female dark agouti rats. Our results indicated that MK-4 inhibited the proliferation of FLS and the development of CIA in a dose-dependent manner. We concluded that MK-4 may represent a new agent for the treatment of RA in the setting of combination therapy with other disease-modifying antirheumatic drugs. Keywords vitamin K2 (menaquinone-4); rheumatoid arthritis; apoptosis; collagen type II-induced arthritis.

show abstract

Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in Japan

Cited by 37 publications

References 7 publications

Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells

Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells

Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients

Vitamin K and rheumatoid arthritis

Contact Info

Product

Resources

About