Vitamin K and rheumatoid arthritis

Okamoto, Hiroshi

doi:10.1002/iub.41

Cited by 25 publications

(17 citation statements)

References 42 publications

(37 reference statements)

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“…Our data are consistent with these observations and suggest that vitamin K2-mediated down-regulation of inflammation may also translate into reduced RANKL production by immune and other cells, thus amplifying the direct suppressive effects of this agent on osteoclastogenesis and bone resorption through inhibitory effects on NF-κB activation. In fact vitamin K2 is reported to mediate potent anti-inflammatory effects on arthritis in vivo and to suppress the development of arthritis in the collagen-induced arthritis (CIA) animal model (49). The importance of the NF-κB pathway in the development of rheumatoid arthritis is well established and the pharmacological suppression of NF-κB activation itself is reported to ameliorate bone erosions in a rheumatoid arthritis animal model in vivo (9).…”

Section: Discussionmentioning

confidence: 99%

Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation

2010

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Abstract. Several bone protective factors are reported to exhibit stimulatory activities on bone formation coupled with inhibitory effects on bone resorption; one such factor is vitamin K2. Vitamin K species [K1 (phylloquinone) and K2 (menaquinone)] have long been associated with bone protective activities and are receiving intense interest as nutritional supplements for the prevention or amelioration of bone disease in humans. However, the mechanisms of vitamin K action on the skeleton are poorly defined. Activation of the nuclear factor κB (NF-κB) signal transduction pathway is essential for osteoclast formation and resorption. By contrast, NF-κB signaling potently antagonizes osteoblast differentiation and function, prompting us to speculate that NF-κB antagonists may represent a novel class of dual anticatabolic and pro-anabolic agents. We now show that vitamin K2 action on osteoblast and osteoclast formation and activity is accomplished by down-regulating basal and cytokineinduced NF-κB activation, by increasing IκB mRNA, in a Á-carboxylation-independent manner. Furthermore, vitamin K2 prevented repression by tumor necrosis factor · (TNF·) of SMAD signaling induced by either transforming growth factor ß (TGFß) or bone morphogenetic protein-2 (BMP-2). Vitamin K2 further antagonized receptor activator of NF-κB (RANK) ligand (RANKL)-induced NF-κB activation in osteoclast precursors. Our data provide a novel mechanism to explain the dual pro-anabolic and anti-catabolic activities of vitamin K2, and may further support the concept that pharmacological modulation of NF-κB signal transduction may constitute an effective mechanism for ameliorating pathological bone loss and for promoting bone health.

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Section: Discussionmentioning

confidence: 99%

Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation

2010

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“…Recently, it was found that MK-4 could induce apoptosis of synovial cells and thus be a novel treatment for RA [17][18]. Therefore, it is necessary to study the correlation between circulating vitamin K homologues levels in RA patients and RA biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients

Ahmed

Kishikawa

Ohyama

et al. 2011

Talanta

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Vitamin K is a fat-soluble vitamin involved in blood coagulation and bone metabolism. The detection and monitoring of vitamin K homologues in rheumatoid arthritis (RA) patients is a challenging problem due to the smaller concentrations of vitamin K and the presence of several interfering medications. Therefore, this study aimed to develop a new highly sensitive and selective chemiluminescence (CL) method designated to quantify vitamin K homologues in plasma of RA patients selectively including phylloquinone (PK, vitamin K 1 ), menaquinone-4 (MK-4, vitamin K 2 ) and menaquinone-7 (MK-7, vitamin K 2 ). The method was based on the unique photochemical properties of vitamin K homologues that were exploited for selective luminol CL reaction. The correlation coefficients of 0.998 or more were obtained in the concentration ranges of 0.1-100 ng mL -1 vitamin K homologues. The detection limits were 0.03-0.1 ng mL -1 in human plasma for vitamin K homologues. The developed HPLC-CL system was successfully applied for selective determination of vitamin K homologues in plasma of RA patients. The developed method may provide a useful tool for monitoring vitamin K homologues in different clinical studies such as RA, osteoporosis and hepatocellular carcinoma in which vitamin K is intervented.

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“…We consider that the use of vitamin K1 oxide in cosmetics may lead to unnecessary sensitization in patients, who may then be denied vitamin K‐containing therapies for treatment of important systemic diseases. Vitamin K is widely used in medicine and new significance therapeutic indications are being studied (17–19).…”

Section: Discussionmentioning

confidence: 99%