Vitamin E supplementation in canine atopic dermatitis: improvement of clinical signs and effects on oxidative stress markers

Abstract

Low levels of plasma vitamin E concentrations were found in canine atopic dermatitis (CAD). The present study was aimed at determining the effect of an eight-week vitamin E supplementation on clinical response (Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) scores and pruritus intensity) in dogs with atopic dermatitis. Levels of oxidative stress markers (plasma malondialdehyde and total antioxidant capacity (TAC), blood glutathione peroxidase and erythrocyte superoxide dismutase, plasma and skin vitamin E concentrations) were also determined. Twenty-nine dogs with CAD were included in the study. Fourteen received vitamin E (8.1 IU/kg once daily, orally) and 15 received mineral oil as placebo (orally). All dogs were treated with antihistamine fexofenadine. Levels of oxidative stress markers (with the exception of skin vitamin E), CADESI-03 and pruritus intensity were determined at the beginning, then every two weeks. Skin vitamin E was determined at the beginning and at the end of the treatment. Significantly higher plasma levels of vitamin E and TAC were observed in the vitamin E group than in the placebo group. CADESI-03 scores determined throughout the treatment in the vitamin E group were significantly lower than in the placebo group. The findings of this study support the supplementation of vitamin E in dogs with atopic dermatitis.

Selected serum oxidative stress biomarkers in dogs with non‐food‐induced and food‐induced atopic dermatitis

“…In the present study, OS was supported by both a significant decrease of antioxidant capacity, except for FRAP values, and increase of oxidative damage in the serum of both NFIAD and FIAD dogs compared to healthy dogs. The OS observed in this study is in accordance with previous reports in canine and human AD, and also in human food allergy . However, in previous studies performed on canine AD, neither distinction between FIAD and NFIAD, nor pruritus was reported, and the biomarkers measured were different compared to this study .…”

“…In addition, there is evidence that OS may be implicated in the pathogenesis of both human and canine AD, through several distinct mechanisms. Data in the veterinary literature regarding oxidative status in canine atopic diseases is limited . We used selected serum biomarkers of OS (sbOS) that have been validated in normal dogs and in dogs with different systemic chronic diseases .…”

Glutathione Peroxidase Activity, Plasma Total Antioxidant Capacity, and Urinary F2‐ Isoprostanes as Markers of Oxidative Stress in Anemic Dogs

“…The most common include the glutathione precursors, SAMe, and N‐acetylcysteine, which increase production of glutathione by provision of cysteine to the hepatocytes and have been associated with improved outcomes in states of oxidative stress in dogs . Vitamin E and vitamin C also have been used for their antioxidant properties and are readily available . Additional studies will be needed to evaluate the need for and impact of antioxidant supplementation in anemic dogs.…”

“…7 Vitamin E and vitamin C also have been used for their antioxidant properties and are readily available. 39,40 Additional studies will be needed to evaluate the need for and impact of antioxidant supplementation in anemic dogs.…”

Effects of Medium Molecular Weight Heparinyl Phenylalnine on Superoxide Dismutase Activity in Mice

“…Recently, participation of free radicals is reported in several diseases, such as in the cardiovascular system (14), Alzheimer's disease (15), arteriosclerosis (16), myocardial infarction (17), cerebral infarction (18), Parkinson's disease (19), pancreatitis (20), glomerulonephritis (21), diabetes (22), cirrhosis (23), stomach ulcers (24), atopic dermatitis (25) and asthma (26,27). Although the research on EC-SOD is advanced and several radical scavengers are under in vivo 30: 841-844 (2016) development, the number of ethical drugs is few.…”