Effects of Medium Molecular Weight Heparinyl Phenylalnine on Superoxide Dismutase Activity in Mice

Effects of Medium Molecular Weight Heparinyl Arginine on Scorpion Venom-induced Pulmonary Edema in Rats

“…We have synthesized and studied a novel medium molecular weight HE (MHE) and its amino acid derivatives (MHADs), in which eleven kinds of amino acids were adducted to MHE to develop safe and effective heparin derivatives. We found that some MHADs had a function as indirect radical scavengers (1)(2)(3). In this paper, we examined the inhibitory action of MHADs on scorpion venom (SV)-induced acute pulmonary edema.…”

Effects of Medium Molecular Weight Heparinyl Phenylalanine on Type I Hypersensitivity

“…MHF, in particular, exhibited not only preventive effects, but also therapeutic effects on ischemic paw edema in mice (5). MHF and MHL also demonstrated radical scavenging ability by increasing the extracellular superoxide dismutase (EC-SOD) activity, and MHF was superior to HE and MHL (6). Furthermore, MHR prevented scorpion venom-induced acute pulmonary edema in rats (7).…”