Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion

Novelli, G. P.; Adembri, Chiara; Gandini, E.; Orlandini, Sandra Zecchi; Papucci, Laura; Formigli, Lucia; Manneschi, Lidia Ibba; Quattrone, Alessandro; Pratesi, Carlo; Capaccioli, S.

doi:10.1016/s0002-9610(97)89593-1

Cited by 54 publications

(46 citation statements)

References 16 publications

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“…It has been demonstrated that vitamin E had a protective effect on oxidative muscle damage after a period of I/R in human. It was observed that MDA level and neutrophil infiltration in muscle fibers decreased in vitamin E-treated patients after a period of I/R [58]. Our results revealed that I/R injury led increases in MDA and PO levels in the skeletal muscle tissue.…”

Section: Resultssupporting

confidence: 54%

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Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Avcı¹,

Kadıoğlu

Şehirli

et al. 2012

Journal of Surgical Research

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Section: Resultssupporting

confidence: 54%

“…The administration of vitamin E prevents the muscles from oxidative stress, endothelial damage, intramuscular edema, and major muscle fiber damage [57,58]. It has been demonstrated that vitamin E had a protective effect on oxidative muscle damage after a period of I/R in human.…”

Section: Resultsmentioning

confidence: 99%

Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Avcı¹,

Kadıoğlu

Şehirli

et al. 2012

Journal of Surgical Research

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“…In fact, serum IL-6 significantly augments at the femoral vein than at the systemic circulation in patients during AAA repair 19 . Patients subjected to open AAA surgical repair have endothelial activation and accumulation of activated neutrophils in muscles as a result of ischemia/reperfusion injury 27,28 . This evidence suggests that the inferior members are the source of inflammation in ischemia/reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

et al. 2007

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PURPOSE: The aim of this study was to investigate whether the hind limbs or intestinal tract is the most important initiator of the inflammatory response secondary aortic clamping and hind limb ischemia/reperfusion injury. METHODS: Blood samples of Wistar rats obtained from posterior cava vein, portal vein, and heart cavity during either laparotomy (control group, n=8) or laparotomy + 2 h of aortic clamping and bilateral hind limb ischemia (ischemia group, n=8), or 2 h after ischemia and 2 h of reperfusion (ischemia-reperfusion group, n=8) were assayed for interleukin 6 (IL-6) and C-reactive protein (CRP). RESULTS: Serum IL-6 at the heart (223.6±197.9 [10-832] pg/mL) was higher (p<0.001) than at both portal (133.08±108.52 [4-372] pg/mL) and posterior cava veins (127.58±109.15 [8-388] pg/mL). CRP was not significant different among groups. CONCLUSION: The splanchnic region is also a source of inflammatory response secondary to ischemia and reperfusion of the hind limbs.

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“…I/R of the lower limb leads to pulmonary edema by means of pulmonary vasoconstriction, pulmonary hypertension and a rise in alveolar membrane permeability [2]. Various drugs have been reported to reduce IRI during aortic cross clamping [5,6]. Recently, studies have demonstrated that hyperbaric oxygenation (HBO) limits the consequences of IRI in various tissues [7,8].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of hyperbaric oxygen and iloprost on ischemia/reperfusion-induced lung injury in a rabbit model

et al. 2012

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BackgroundThe role of multiorgan damage in the mortality caused by ischemic limb injury is still not clarified. The objective of this study was to examine the potential protective effects of hyperbaric oxygen (HBO) and iloprost (IL) therapy on lung damage induced by limb ischemia/reperfusion injury in a rabbit model, using both biochemical and histopathological aspects.MethodsForty New Zealand white rabbits were randomly allocated into one of five study groups: HBO group (single session of HBO treatment); IL group (25 ng/kg/min infusion of IL); HBO + IL group (both HBO and IL); Control group (0.9% saline only); and a sham group. Acute hind limb ischemia-reperfusion was established by clamping the abdominal aorta for 1 h. HBO treatment and IL infusion were administrated during 60 min of ischemia and 60 min of reperfusion period. Blood pH, partial pressure of oxygen, partial pressure of carbon dioxide and levels of bicarbonate, sodium, potassium, creatine kinase, lactate dehydrogenase, and tumor necrosis factor alpha were determined at the end of the reperfusion period. Malondialdehyde was measured in the plasma and lung as an indicator of free radicals. After sacrifice, left lungs were removed and histopathological examination determined the degree of lung injury.ResultsIn the control group, blood partial pressure of oxygen and bicarbonate levels were significantly lower and creatine kinase, lactate dehydrogenase, malondialdehyde and tumor necrosis factor-α levels were significantly higher than those of the HBO group, IL group, HBO + IL group and sham group. Similarly, the malondialdehyde levels in the lung tissue and plasma levels were significantly lower in the treatment groups compared with the control group. The extent of lung injury according to the histological findings was significantly higher in the control group.ConclusionsThese results suggest that both HBO and IL therapies and their combination might be effectively used in the prevention of lung injury after ischemia/reperfusion injury of the lower extremities.

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Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion

Cited by 54 publications

References 16 publications

Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

Protective effects of hyperbaric oxygen and iloprost on ischemia/reperfusion-induced lung injury in a rabbit model

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