The intestinal tract as the major source of interleukin 6 production during abdominal aortic clamping and hind limb ischaemia-reperfusion injury

Pimenta, Márcio Benedito Palma; Aguilar-Nascimento, José Eduardo de; Martins, Dely Cristina; Silva, Daniele Ribastski da; Bacelo, Kátia Leston; Bocchese, Isabel Cristina; Zaffani, Sarai; Zaffani, Elieser; Silveira, Érika Alessandra Oliveira; Carmo, Aracelle Victor do; Ferreira, Simone Sampaio Saldanha

doi:10.1590/s0102-86502007000700008

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…Table S6 in Additional file 6 summarizes the mechanistic studies of mediators in animal models [ 124 – 170 ]. Thirty-nine of the 47 studies used rodents to develop abdominal sepsis models (i.e., cecum ligation and puncture (CLP)) [ 124 , 125 , 127 , 128 , 131 – 133 , 136 – 138 , 143 , 145 , 151 , 154 , 156 , 157 , 159 , 162 , 164 , 165 , 167 – 170 ], or shock-resuscitation, or abdominal compartment syndrome (ACS), or two-hit models [ 126 , 130 , 132 , 135 – 140 , 142 , 144 , 146 – 150 , 152 , 160 – 162 , 166 ]. The remaining utilized swine [ 129 , 134 , 155 , 158 , 163 ], baboons [ 141 ], or dogs [ 153 ].…”

Section: Resultsmentioning

confidence: 99%

Inflammatory mediators in intra-abdominal sepsis or injury – a scoping review

et al. 2015

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IntroductionInflammatory and protein mediators (cytokine, chemokine, acute phase proteins) play an important, but still not completely understood, role in the morbidity and mortality of intra-abdominal sepsis/injury. We therefore systematically reviewed preclinical and clinical studies of mediators in intra-abdominal sepsis/injury in order to evaluate their ability to: (1) function as diagnostic/prognostic biomarkers; (2) serve as therapeutic targets; and (3) illuminate the pathogenesis mechanisms of sepsis or injury-related organ dysfunction.MethodsWe searched MEDLINE, PubMed, EMBASE and the Cochrane Library. Two investigators independently reviewed all identified abstracts and selected articles for full-text review. We included original studies assessing mediators in intra-abdominal sepsis/injury.ResultsAmong 2437 citations, we selected 182 studies in the scoping review, including 79 preclinical and 103 clinical studies. Serum procalcitonin and C-reactive protein appear to be useful to rule out infection or monitor therapy; however, the diagnostic and prognostic value of mediators for complications/outcomes of sepsis or injury remains to be established. Peritoneal mediator levels are substantially higher than systemic levels after intra-abdominal infection/trauma. Common limitations of current studies included small sample sizes and lack of uniformity in study design and outcome measures. To date, targeted therapies against mediators remain experimental.ConclusionsWhereas preclinical data suggests mediators play a critical role in intra-abdominal sepsis or injury, there is no consensus on the clinical use of mediators in diagnosing or managing intra-abdominal sepsis or injury. Measurement of peritoneal mediators should be further investigated as a more sensitive determinant of intra-abdominal inflammatory response. High-quality clinical trials are needed to better understand the role of inflammatory mediators.Electronic supplementary materialThe online version of this article (doi:10.1186/s13054-015-1093-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Inflammatory mediators in intra-abdominal sepsis or injury – a scoping review

et al. 2015

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“…Moreover, IL-1 primarily serves a role in chemoattraction, macrophage stimulation and increase of downstream cell and chemical factors. IL-6 is also involved in systemic immune responses and inflammatory cascades, and can activate neutrophils to exacerbate the production of inflammatory mediators after trauma, effectively enhancing the severity of tissue injury (30). MPO is produced by polymorphonuclear leukocytes, and the levels of active MPO reflect the activation of polymorphonuclear leukocytes in the lungs (31).…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture pre‑conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF‑κB in rats

Lou

et al. 2020

Mol Med Rep

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limb ischemia/reperfusion (i/r) can induce inflammation, causing acute lung injury. The Toll-like receptor 4 (Tlr4)/nF-κB pathway plays an important role in acute and chronic inflammatory disorders. Several studies have demonstrated the efficacy of acupuncture in lung inflammatory injury. The aim of the present study was to elucidate the mechanism underlying the protective effect of electroacupuncture (ea) against lung injury induced by limb i/r. ea applied at the Zusanli and Sanyinjiao acupoints attenuated lung injury and decreased the secretion of inf lammatory factors such as tumor necrosis factor-α, interleukin (il)-1, il-6 and myeloperoxidase. Moreover, the expression levels of TLR4 and NF-κB were suppressed by EA. Thus, the present findings suggested that EA can reduce pulmonary inflammation induced by limb I/R injury, possibly via the inhibition of the TLR4/NF-κB pathway.

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“…Although reperfusion is essential for the survival of ischemic tissue, there is good evidence that reperfusion itself causes additional cellular injury. Renal ischemia-reperfusion (I/R) injury is caused by multiple mechanisms involving tubular cell apoptosis, oxygen free radical formation, mitochondrial dysfunction, inflammatory cytokine generation, and neutrophil sequestration [3][4][5]. I/R injury is closely associated with acute renal injury leading to increased acute rejection and unacceptable high mortality of patients [6].…”

Section: Introductionmentioning

confidence: 99%