2020
DOI: 10.1590/2175-8239-jbn-2019-0192
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Abstract: Fortification of food products with vitamin D was central to the eradication of rickets in the early parts of the 20th century in the United States. In the subsequent almost 100 years since, accumulating evidence has linked vitamin D deficiency to a variety of outcomes, and this has paralleled greater public interest and awareness of the health benefits of vitamin D. Supplements containing vitamin D are now widely available in both industrialized and developing countries, and many are in the form of unregulate… Show more

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Cited by 15 publications
(16 citation statements)
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References 25 publications
(16 reference statements)
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“…Toxicity is related to high calcium levels; 25(OH)D levels higher than 150 ng/ml in conjunction with high calcium levels produce weakness, GI symptoms and accompanying weight loss, arrhythmias, confusion, and kidney damage (28,88,92). Historically, toxic levels of vitamin D (>150 ng/ml) have almost exclusively been the result of industrial errors (inaccurate doses in supplements or fortified foods), and the few cases of toxicity from extremely high doses being intentionally taken for prolonged periods of time (sometimes under the direction of a health care practitioner) were rarely severe (94,95).…”
Section: Controversy Concerning Risk Of Overdosementioning
confidence: 99%
See 1 more Smart Citation
“…Toxicity is related to high calcium levels; 25(OH)D levels higher than 150 ng/ml in conjunction with high calcium levels produce weakness, GI symptoms and accompanying weight loss, arrhythmias, confusion, and kidney damage (28,88,92). Historically, toxic levels of vitamin D (>150 ng/ml) have almost exclusively been the result of industrial errors (inaccurate doses in supplements or fortified foods), and the few cases of toxicity from extremely high doses being intentionally taken for prolonged periods of time (sometimes under the direction of a health care practitioner) were rarely severe (94,95).…”
Section: Controversy Concerning Risk Of Overdosementioning
confidence: 99%
“…Although vitamin D toxicity is extremely rare, considering the recent spate of chloroquine overdoses due to panic from COVID-19, recommendations include cautioning the public that excessive artificial supplementation can lead to serious harm (94,225,249,250). Suresh noted that in India, vitamin D deficiency is due in large part to calcium deficiency, which must therefore also be addressed (234).…”
Section: Covid-19-specific Recommendations Of Expertsmentioning
confidence: 99%
“…There were no reported complications following vitamin D administration in this study. Some previous studies reported complications that occurred from iatrogenic accidental overdoses [ 22 ]. The clinical presentation of vitamin D toxicity may range from asymptomatic to life-threatening features resulting from persistent, prolonged hypercalcemia.…”
Section: Discussionmentioning
confidence: 99%
“…Ниркові симптоми включають гіперкальціурію як першу ознаку, поліурію, полідипсію, дегідратацію, нефрокальциноз та ниркову недостатність. Інші симптоми токсичності вітаміну D, спричинені гіперкальціємією, включають стрічкову кератопатію, втрату слуху та періартикулярний кальциноз [33][34][35].…”
Section: синдром токсичности витамина D: взгляд токсикологаunclassified
“…Renal symptoms include hypercalciuria as the first sign, polyuria, polydipsia, dehydration, nephrocalcinosis, and renal failure. Other symptoms of vitamin D toxicity caused by hypercalcemia include tape keratopathy, hearing loss, and periarticular calcification [33][34][35].…”
Section: синдром токсичности витамина D: взгляд токсикологаmentioning
confidence: 99%