Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency

Ardabili, Hania R.; Gargari, Bahram Pourghassem; Farzadi, Laya

doi:10.1016/j.nutres.2012.02.001

Cited by 81 publications

(105 citation statements)

References 35 publications

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“…The only randomized placebo-controlled trial that administered vitamin D3 and examined metabolic disturbances as primary prespecified outcomes did not indicate a significant effect on IR after the administration of three oral doses of vitamin D3 in 2 months. The increase in serum 25OHD levels was 40 nmol/l in the vitamin D group (30). The authors did find a significant increase in insulin secretion in the vitamin D group, but compared with the placebo group, this was not significant.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 85%

“…Ten intervention trials had been carried out and published until our search in January 2013 (30,31,32,33,34,35,36,37,38,39,40). Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31).…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31). One RCT carried out by Ardabili et al had a randomized placebo-controlled double-blind study design in which the effect of vitamin D3 supplementation on metabolic parameters and cardiovascular risk factors was evaluated in 50 PCOS women.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…One RCT carried out by Ardabili et al had a randomized placebo-controlled double-blind study design in which the effect of vitamin D3 supplementation on metabolic parameters and cardiovascular risk factors was evaluated in 50 PCOS women. This trial resulted in two articles included in this review (30,34). In their RCT, Sathyapalan et al The number of participants included in the intervention trials ranged from 11 to 100, and all were premenopausal PCOS women.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…Seven intervention trials examined the effect of vitamin D supplementation on IR and other metabolic characteristics (30,32,33,36,37,39,40). The only randomized placebo-controlled trial that administered vitamin D3 and examined metabolic disturbances as primary prespecified outcomes did not indicate a significant effect on IR after the administration of three oral doses of vitamin D3 in 2 months.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

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The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

109

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Context: Metabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS. Objective: The aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS. Design and methods: A systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature. Results: We found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women. Conclusions: Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

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Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 85%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

See 3 more Smart Citations

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

109

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2013

Cochrane Database of Systematic Reviews

117

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2017

Cochrane Database of Systematic Reviews

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Background A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results. This review assesses the evidence for the effectiveness of different antioxidants in female subfertility. Objectives To determine whether supplementary oral antioxidants compared with placebo, no treatment/standard treatment or another antioxidant improve fertility outcomes for subfertile women. Search methods We searched the following databases (from their inception to September 2016) with no language or date restriction: Cochrane Gynaecology and Fertility Group (CGFG) specialised register, the Cochrane Central Register of Studies (CENTRAL CRSO), MEDLINE, Embase, PsycINFO, CINAHL and AMED. We checked reference lists of appropriate studies and searched for ongoing trials in the clinical trials registers. Selection criteria We included randomised controlled trials (RCTs) that compared any type, dose or combination of oral antioxidant supplement with placebo, no treatment or treatment with another antioxidant, among women attending a reproductive clinic. We excluded trials comparing antioxidants with fertility drugs alone and trials that only included fertile women attending a fertility clinic because of male partner infertility. Data collection and analysis Two review authors independently selected eligible studies, extracted the data and assessed the risk of bias of the included studies. The primary review outcome was live birth; secondary outcomes included clinical pregnancy rates and adverse events. We pooled studies using a fixed-effect model, and calculated odds ratios (ORs) with 95% confidence intervals (CIs) for the dichotomous outcomes of live birth, clinical pregnancy and adverse events. We assessed the overall quality of the evidence by applying GRADE criteria.

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Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency

Cited by 81 publications

References 35 publications

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Antioxidants for female subfertility

Antioxidants for female subfertility

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