The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel, Yvonne H M; Snackey, Chantal; Louwers, Yvonne V.; Lips, Paul; Lambalk, Cornelis B.; Laven, Joop S.E.; Şimşek, Suat

doi:10.1530/eje-13-0617

Cited by 108 publications

(82 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested that vitamin D status may contribute to the development of the metabolic disturbances associated with PCOS, chiefly insulin resistance and glucose intolerance states (95). Current evidence, based on a recent systematic review, supports an inverse association between vitamin D serum levels and body weight and metabolic alterations in PCOS (96,97).…”

Section: Laboratory and Biomarkersmentioning

confidence: 99%

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

Conway¹,

Dewailly²,

Diamanti-Kandarakis³

et al. 2014

European Journal of Endocrinology

556

482

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of endocrinologists. Great efforts have been made in the last 2 decades to define the syndrome. The presence of three different definitions for the diagnosis of PCOS reflects the phenotypic heterogeneity of the syndrome. Major criteria are required for the diagnosis, which in turn identifies different phenotypes according to the combination of different criteria. In addition, the relevant impact of metabolic issues, specifically insulin resistance and obesity, on the pathogenesis of PCOS, and the susceptibility to develop earlier than expected glucose intolerance states, including type 2 diabetes, has supported the notion that these aspects should be considered when defining the PCOS phenotype and planning potential therapeutic strategies in an affected subject. This paper offers a critical endocrine and European perspective on the debate on the definition of PCOS and summarises all major aspects related to aetiological factors, including early life events, potentially involved in the development of the disorder. Diagnostic tools of PCOS are also discussed, with emphasis on the laboratory evaluation of androgens and other potential biomarkers of ovarian and metabolic dysfunctions. We have also paid specific attention to the role of obesity, sleep disorders and neuropsychological aspects of PCOS and on the relevant pathogenetic aspects of cardiovascular risk factors. In addition, we have discussed how to target treatment choices based according to the phenotype and individual patient's needs. Finally, we have suggested potential areas of translational and clinical research for the future with specific emphasis on hormonal and metabolic aspects of PCOS.

show abstract

Section: Laboratory and Biomarkersmentioning

confidence: 99%

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

Conway¹,

Dewailly²,

Diamanti-Kandarakis³

et al. 2014

European Journal of Endocrinology

556

482

View full text Add to dashboard Cite

show abstract

“…7 Coexistence of hyperinsulinemia, VDD and AE in women has frequently been described, 8,9 and the prevalence of VDD in women with AE is 67%-85%. 10,11 Taking into consideration the frequent comorbidities of PCOS and VDD with hyperinsulinemia, in the recent article, we aimed to examine some metabolic parameters and early alterations in the coronary resistance artery function in an animal model, in which female rats were subjected to excess androgen (inducing explicit PCOS histology in ovaries) with and without VDD deficiency. [12][13][14][15] …”

Section: Introductionmentioning

confidence: 99%

Insulin resistance in an animal model of polycystic ovary disease is aggravated by vitamin D deficiency: Vascular consequences

Hadjadj

Várbı́ró

Horváth

et al. 2018

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

Hyperandrogenic state in females is accompanied with metabolic syndrome, insulin resistance and vascular pathologies. A total of 67%-85% of hyperandrogenic women suffer also from vitamin D deficiency. We aimed to check a potential interplay between hyperandrogenism and vitamin D deficiency in producing insulin resistance and effects on coronary resistance arteries. Adolescent female rats were divided into four groups, 11-12 animals in each. Transdermal testosterone-treated and vehicle-treated animals were kept either on vitamin D-deficient or on vitamin D-supplemented diet for 8 weeks. Plasma sexual steroid, insulin, leptin and vitamin D plasma levels were measured, and oral glucose tolerance test was performed. In coronary arterioles, insulin receptor and vitamin D receptor expressions were tested by immunohistochemistry, and insulin-induced relaxation was measured in vitro on isolated coronary resistance artery segments. Testosterone impaired glucose tolerance, and it diminished insulin relaxation but did not affect the expression of insulin and vitamin D receptors in vascular tissue. Vitamin D deficiency elevated postprandial insulin levels and homeostatic model assessment insulin resistance. It also diminished insulin-induced coronary arteriole relaxation, while it raised the expression of vitamin D and insulin receptors in the endothelial and medial layers. Our conclusion is that both hyperandrogenism and vitamin D deficiency reduce sensitivity of coronary vascular tissue to insulin, but they do it with different mechanisms.

show abstract

“…Although the literature reports an inverse relationship between vitamin d levels and insulin resistance in PCOS patients, these studies are still very heterogeneous, hencehindering a conclusion [24].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and polycystic ovary syndrome: an integrating review

Lopes¹,

Meireles

Ferreira³

et al. 2017

int arch med

View full text Add to dashboard Cite

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathyin women of reproductive age. It causes a metabolic syndrome characterized by insulin resistance, hyperinsulinemia, and dyslipidemia. Vitamin d deficiency and its association with PCOS still represents a controversial subject in the literature.Objective: In this context, this study aimed to understand the association between polycystic ovary syndrome and vitamin d deficiency, and how it occurs. Method:It was an integrative review conducted in the PubMed, Scopus, LILACS, and CINAHL databases from August 2016 to January 2017, with a sample of 7 articles analyzed in their entirety. Results:The evidences according to the studies conducted and the conclusions they identified. Conclusions:It was concluded that we cannot yet assume that vitamin d deficiency contributes to the pathogenesis of PCOS, nor that the syndrome causes vitamin d deficiency, since the studies are controversial and there is a need for research with higher levels of evidence to clarify these doubts.

show abstract

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Cited by 108 publications

References 53 publications

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

The polycystic ovary syndrome: a position statement from the European Society of Endocrinology

Insulin resistance in an animal model of polycystic ovary disease is aggravated by vitamin D deficiency: Vascular consequences

Vitamin D and polycystic ovary syndrome: an integrating review

Contact Info

Product

Resources

About