Antioxidants for female subfertility

Abstract

Analysis 3.1. Comparison 3 Pentoxifylline versus placebo or no treatment/standard care, Outcome 1 Live birth; pentoxifylline vs placebo or no treatment/standard treatment (natural conceptions and undergoing fertility treatments

Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters

“…Melatonin is a highly safe preparation when used as an antioxidant. No serious side effects were observed in any of the studies (21). No teratogenic effects were observed in the pregnant or infertile patient population (22).…”

Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters

“…Melatonin is a highly safe preparation when used as an antioxidant. No serious side effects were observed in any of the studies (21). No teratogenic effects were observed in the pregnant or infertile patient population (22).…”

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

“…Melatonin supplementation may improve the clinical outcomes of ART only in a subset of infertile patients. Cochrane's systematic review also concluded that oral antioxidants, including combinations of N-acetyl-cysteine, melatonin, L-arginine, vitamin E, myo-inositol, vitamin C, vitamin D-calcium, and omega-3-polyunsaturated fatty acids, are not associated with increased live birth rates (OR 1.25, 95 % CI 0.19-8.26, p = 0.82) or clinical pregnancy rates (OR 1.30, 95 % CI 0.92-1.85, p = 0.14) compared to those seen with placebo or no treatment [63].…”

Clinical adjuncts in in vitro fertilization: a growing list

“…A recent Cochrane meta-analysis ( 15) pooled the results of RCTs and found no evidence for an increased LBR with antioxidants compared with placebo or no treatment (OR 1.21; 95% CI, 0.69-2.11; 4 RCTs, n ¼ 230). Neither was there any statistically significant difference in clinical pregnancy rates noted (OR 1.19; 95% CI, 0.98-1.43; 15 RCTs, n ¼ 2,263) (15).…”

Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters

“…Melatonin is a highly safe preparation when used as an antioxidant. No serious side effects were observed in any of the studies (21). No teratogenic effects were observed in the pregnant or infertile patient population (22).…”

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

“…Melatonin supplementation may improve the clinical outcomes of ART only in a subset of infertile patients. Cochrane's systematic review also concluded that oral antioxidants, including combinations of N-acetyl-cysteine, melatonin, L-arginine, vitamin E, myo-inositol, vitamin C, vitamin D-calcium, and omega-3-polyunsaturated fatty acids, are not associated with increased live birth rates (OR 1.25, 95 % CI 0.19-8.26, p = 0.82) or clinical pregnancy rates (OR 1.30, 95 % CI 0.92-1.85, p = 0.14) compared to those seen with placebo or no treatment [63].…”

Clinical adjuncts in in vitro fertilization: a growing list

“…A recent Cochrane meta-analysis ( 15) pooled the results of RCTs and found no evidence for an increased LBR with antioxidants compared with placebo or no treatment (OR 1.21; 95% CI, 0.69-2.11; 4 RCTs, n ¼ 230). Neither was there any statistically significant difference in clinical pregnancy rates noted (OR 1.19; 95% CI, 0.98-1.43; 15 RCTs, n ¼ 2,263) (15).…”

Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters

“…Melatonin is a highly safe preparation when used as an antioxidant. No serious side effects were observed in any of the studies (21). No teratogenic effects were observed in the pregnant or infertile patient population (22).…”

Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

“…Melatonin supplementation may improve the clinical outcomes of ART only in a subset of infertile patients. Cochrane's systematic review also concluded that oral antioxidants, including combinations of N-acetyl-cysteine, melatonin, L-arginine, vitamin E, myo-inositol, vitamin C, vitamin D-calcium, and omega-3-polyunsaturated fatty acids, are not associated with increased live birth rates (OR 1.25, 95 % CI 0.19-8.26, p = 0.82) or clinical pregnancy rates (OR 1.30, 95 % CI 0.92-1.85, p = 0.14) compared to those seen with placebo or no treatment [63].…”

Clinical adjuncts in in vitro fertilization: a growing list

“…A recent Cochrane meta-analysis ( 15) pooled the results of RCTs and found no evidence for an increased LBR with antioxidants compared with placebo or no treatment (OR 1.21; 95% CI, 0.69-2.11; 4 RCTs, n ¼ 230). Neither was there any statistically significant difference in clinical pregnancy rates noted (OR 1.19; 95% CI, 0.98-1.43; 15 RCTs, n ¼ 2,263) (15).…”