Vitamin D supplementation after malnutrition associated with time-related increase of cancer diagnoses: A cohort study of 389 patients with Wernicke-Korsakoff syndrome

Wijnia, Jan W.; Oudman, Erik; Wierdsma, André I.; Oey, Misha J.; Bongers, Jeroen; Postma, Albert

doi:10.1016/j.nut.2019.05.008

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…15,16 In contrast, a retrospective cohort study of 389 malnourished patients with alcoholic Wernicke-Korsakoff syndrome found an increased time-related risk of cancer development; with the temporal relationship between vitamin D supplementation and newly diagnosed cancer being significant when the administration was started within the year leading up to the diagnosis. 17 With regard to the limitations of the current case report, there was no possibility to determine thiamine concentrations or measure the red blood cell transketolase activity in the patient. 18 Another shortcoming of this case report was that the patient's compliance with vitamin D administration could not be fully monitored after hospital discharge.…”

Section: Discussionmentioning

confidence: 89%

“…15,16 In contrast, a retrospective cohort study of 389 malnourished patients with alcoholic Wernicke–Korsakoff syndrome found an increased time-related risk of cancer development; with the temporal relationship between vitamin D supplementation and newly diagnosed cancer being significant when the administration was started within the year leading up to the diagnosis. 17…”

Section: Discussionmentioning

confidence: 99%

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Concomitant occurrence of Wernicke’s encephalopathy and sarcopenia due to vitamin D depletion in patients with alcohol use disorder: a case report

et al. 2023

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Individuals with alcohol use disorder frequently suffer from vitamin D deficiency, in addition to deficiencies in vitamins B12, folic acid and B1. This is due to inadequate dietary intake and behavioural changes. Each of these deficiencies results in different clinical symptoms. Subacute spinal cord degeneration, together with radicular and sensorimotor peripheral neuropathy, arises from B12 vitamin and folic acid deficiencies. B1 vitamin deficiency leads to Wernicke’s encephalopathy, which can include the classical triad of symptoms (i.e. cognitive changes, ataxia and ophthalmoplegia). Sarcopenia is a consequence of a long-term deficiency of vitamin D. This current case report describes a 43-year-old female patient with alcohol use disorder who complained of dizziness, postural disturbance and episodes of intermittent paraesthesia. She was subsequently shown to have concomitant Wernicke’s encephalopathy and sarcopenia due to vitamin D deficiency. This case report presents the diagnostic process undertaken to exclude conditions related to ataxia and paraparesis other than vitamins D and B1 deficiencies. It also emphasizes the importance of concomitant replacement of the depleted vitamins because the vitamin deficiency may occur simultaneously, which causes the accompanying manifestations of several clinical syndromes.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Concomitant occurrence of Wernicke’s encephalopathy and sarcopenia due to vitamin D depletion in patients with alcohol use disorder: a case report

et al. 2023

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“…A translational rodent model showed neuroanatomical substrates for memory loss resembling, although not wholly replicating human WKS (Savage et al, 2012). A European center found that WKS patients started on supplemental vitamin D within the previous year had a higher cancer rate than other WKS patients at p < 0.011 (Wijnia et al, 2019). Logistic regression analysis further revealed that tobacco smoking and length of stay significantly increased the odds ratios for cancer in WKS patients (respectively, odds ratio = 2.74 and 1.68).…”

Section: Literature Search Reviewmentioning

confidence: 99%

Identifying, Assessing, and Treating Korsakoff Syndrome Patients

et al. 2021

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Objectives consist of updating published reports on the recognition, assessment, and care of patients with Wernicke-Korsakoff syndrome (WKS). Methods included defining relevant terms, describing core clinical phenomena, conducting meaningful reviews for latter-day WKS publications, and selecting instructive case examples. Findings covered epidemiology, precipitants, neuroimaging studies, alternate learning strategies in WKS, adjunctive treatments, and promising research. In conclusion, patients, their family members, clinicians, and public health experts should benefit from this updated knowledge. Countries with substantial alcohol consumption should consider emulating Holland in designating WKS research centers, founding regional clinical facilities, and funding multidisciplinary expert teams.

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Wernicke-Korsakoff syndrome diagnostics and rehabilitation in the post-acute phase

Oudman

Oey²,

Batjes³

et al. 2022

Addiction Neuroscience

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Vitamin D supplementation after malnutrition associated with time-related increase of cancer diagnoses: A cohort study of 389 patients with Wernicke-Korsakoff syndrome

Cited by 8 publications

References 24 publications

Concomitant occurrence of Wernicke’s encephalopathy and sarcopenia due to vitamin D depletion in patients with alcohol use disorder: a case report

Concomitant occurrence of Wernicke’s encephalopathy and sarcopenia due to vitamin D depletion in patients with alcohol use disorder: a case report

Identifying, Assessing, and Treating Korsakoff Syndrome Patients

Wernicke-Korsakoff syndrome diagnostics and rehabilitation in the post-acute phase

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