Identifying, Assessing, and Treating Korsakoff Syndrome Patients

Westermeyer, Joseph; Soukup, Beverly; Mayer, John R.; Lee, Kathryn

doi:10.1097/nmd.0000000000001351

Cited by 4 publications

(4 citation statements)

References 82 publications

(101 reference statements)

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“…It has been reported that neurons could be irreversibly damaged by a lack of thiamine, thus failing to respond to thiamine treatment even when presented with adequate amounts [ 9 , 17 ]. Bolus IV thiamine infusion is mostly considered unhelpful after patients have passed the acute stage of Wernicke syndrome [ 6 , 12 ]. This could explain Mr. A's failure to improve following his IV thiamine infusion.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, alcohol use can also lead to Wernicke's encephalopathy and Korsakoff syndrome. The clinical presentation of each of these two conditions can be diverse and complicated [ 6 – 9 ]. Moreover, patients with severe mental illnesses such as schizophrenia and bipolar disorder can also gradually develop cognitive deficits [ 4 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech

Deng

Negro

Jung

et al. 2022

Case Reports in Psychiatry

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Our patient Mr. A is a mentally and physically disabled gentleman. He was first diagnosed with bipolar disorder as a teenager. He incurred a lumbar spinal injury due to a motor vehicle incident in his 20s which led to weakness, numbness, and frequent infection over both of his lower extremities. He also developed alcohol addiction over the course of his life. Mr. A presented to our facility with complicated neuropsychiatric symptoms. By adopting various clinical strategies, we were able to control his symptoms of agitation, self-harm, mood swings, and stereotyped behavior. However, we were not able to improve his neurocognitive functioning or speech impairment which seemed to become severe and irreversible in a period of a few months. We felt disappointed and perplexed by the mixed treatment responses. To understand Mr. A’s clinical presentation, various laboratory tests and imaging studies were performed. Different psychotropic medications were used to manage his symptoms. Gradually, we felt that we were able to understand this case better clinically and etiologically. His bipolar disorder, alcohol addiction, and physical injury had likely all contributed to his neuropsychiatric symptoms, directly or indirectly. It is highly possible that an alcohol-related progressive dementia along with his chronic bipolar disorder played a key role in the progression of his brain neurodegeneration. Also, Wernicke-Korsakoff syndrome could reasonably be considered having developed during his clinical course. Moreover, the fluctuation of the patient’s neuropsychiatric symptoms we observed during his hospitalization reflects the increased vulnerability of the human brain under sustained neurodegeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech

Deng

Negro

Jung

et al. 2022

Case Reports in Psychiatry

View full text Add to dashboard Cite

show abstract

“…Det anslås at fra 50 til 70-80 % av AUD-pasienter har en eller annen grad av kognitiv forstyrrelse, og at en andel av disse igjen har en kognitiv svekkelse av klinisk betydning (Bates et al, 2013;Bernardin et al, 2014;Nixon & Lewis, 2019). En liten andel personer med høyt alkoholinntak over lang tid vil kunne utvikle mer alvorlige kognitive svekkelser, som Korsakoffs syndrom eller alkoholassosiert demens (Westermeyer et al, 2021).…”

Section: Kognitive Vanskerunclassified

Behandling av alkoholbrukslidelse: pasientfaktorers betydning for gjennomføring og utfall

Høiland¹,

Egeland²

2022

TNPF

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Alcohol use disorder (AUD) is among the three most common mental disorders in Norway. In general, treatment is provided by interdisciplinary specialized substance use disorder clinics. However, a substantial portion of AUD patients do not receive effective treatments, and we need to develop more efficient treatments that are tailored to the patient. This article presents findings from a clinically situated literature search on the significance of patient factors for completion and outcomes of AUD treatment. We found that severity of alcohol dependence, social network, personality disorders and cognitive impairments were significant factors for completion and outcomes in AUD treatment. Demographic factors such as gender and age were of minor importance. This can be useful hands-on knowledge for clinicians working in the field of addiction treatment when providing and adapting treatment to AUD patients. Keywords: alcohol use disorder, evidence-based practice, patient factors, treatment outcome, psychotherapy.

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Section: Kognitive Vanskerunclassified

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2022

TNPF

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Identifying, Assessing, and Treating Korsakoff Syndrome Patients

Cited by 4 publications

References 82 publications

Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech

Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech

Behandling av alkoholbrukslidelse: pasientfaktorers betydning for gjennomføring og utfall

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