Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans

Barker, Tyler; Martins, Thomas B.; Hill, Harry R.; Kjeldsberg, Carl R.; Dixon, Brian; Schneider, Erik; Henriksen, Vanessa T.; Weaver, Lindell K.

doi:10.1016/j.cyto.2013.12.004

Cited by 41 publications

(39 citation statements)

References 13 publications

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“…Work and fatigue were not modulated by supplemental vitamin D despite previous trends for vitamin D sufficient [43] and vitamin D treated adults [31] to perform more repetitions during and to display greater deficits in peak isometric force and peak power output immediately after exercise. Although it is beyond the scope of this study, several potential explanations could account for the inability of supplemental vitamin D to alter work or work fatigue.…”

Section: Discussioncontrasting

confidence: 68%

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Barker

Rogers

Levy³

et al. 2015

Cytokine

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Section: Discussioncontrasting

confidence: 68%

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Barker

Rogers

Levy³

et al. 2015

Cytokine

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“…b Quantitation results. n = 6; **p < 0.01 when compared to control group; △△ p < 0.01 when compared to high-intensity group One implication of these findings is that calcitriol may be used to protect the bones of military recruits and elite athletes with excessive training, as exhaustive exercise causes inflammation and produces free radicals, which may negatively regulate bone mass accrual [65,66]. In response to exhaustive exercise, calcitriol may execute its anti-inflammation and anti-reactive oxygen species (ROS) effects, thus leading to an increase in bone mass.…”

Section: A Link Between Exercise and Vitamin D?mentioning

confidence: 90%

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength

Zhang

Chen

et al. 2016

J Bone Miner Metab

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Physical exercise is beneficial to bone health. However, little is known how different intensities of exercise affect bone mass and strength. In the present study, we used young mice to study the effects of different intensities of exercise on bone mass and bone strength in comparison to pharmacological doses of active vitamin D (calcitriol). We found that only the medium level of exercise tested showed a positive effect on bone mineral density, trabecular bone volume, and bone strength, which are attributable to a decrease in bone resorption and an increase in bone formation, with the latter being accompanied by an increase in the number of osteogenic mesenchymal stem cells in the bone marrow. Calcitriol increases bone volume and bone strength, yet the combination of calcitriol and medium-intensity exercise did not further improve bone mass or strength. Moreover, calcitriol also showed some protective effect on the bone in mice with high levels of exercise. These results indicate that exercise at medium intensity increases bone mass and strength via affecting both bone formation and resorption and that its beneficial effects on bone mass cannot be further improved by calcitriol.

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“…Five studies [34][35][36][37][38] recruited healthy participants, amongst these studies, one reported a significant improvement in the inflammatory marker hs-CRP (mean ± SD) 4.53 ± 0.64 µg/ml -3.12 ± 0.46 µg/ml, P = 0.01) [34]. The remaining four studies did not report significant improvements in the markers/parameters measured.…”

Section: Studies In Healthy Participantsmentioning

confidence: 99%

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Agbalalah

Hughes

Freeborn

et al. 2017

The Journal of Steroid Biochemistry and Molecular Biology

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Highlights• Vitamin D deficiency has been identified as a potential risk factor for cardiovascular disease.• Review of RCTs of effects of vitamin D supplementation on endothelial function/inflammation.• 8/29 studies reported improvements in the endothelial/inflammatory parameters measured.• This review does not support use of vitamin D as a preventative measure for CVD. AbstractThis systematic review aims to evaluate randomised controlled trials (

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Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans

Cited by 41 publications

References 13 publications

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: A randomized, double blind, placebo-controlled study

The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

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