Vitamin D status is related to severity at onset of diabetes and worse glycemic control

Segovia‐Ortí, Raquel; Bennassar, A. Barceló; Sotto-Esteban, Diego de; Sanchís, Pilar

doi:10.1515/jpem-2020-0149

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…A summary of the selection process for the studies is presented in Fig. 1 Descriptions of included studies Out of the 45 studies, 19 had cross-sectional designs [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], 23 were case-control studies , 2 had baseline cross-sectional data from a longitudinal study [64,65] and one was based on the baseline data of a cohort study [66]. The reported data also included 6,995 participants, mostly aged ≤ 18 years old, of which 2,436 were children/adolescents with T1D as well as vitamin D de ciency (sample size n=13~1,426).…”

Section: Resultsmentioning

confidence: 99%

“…In accordance with the recommended NOS and AHRQ criteria, only studies of acceptable quality were included in the present meta-analysis; eight studies received 9 stars [51,53,[56][57][58]62,63,66], ten studies received 8 stars [43,[48][49][50]52,54,55,[59][60][61], ve studies received 7 stars [42,[44][45][46][47] and one study received 6 stars [41]. When using the quality assessment criteria from the AHRQ, three studies received a score of 11 [24,29,65], ten received a score of 10 [22,25,28,29,31,33,34,36,39,40], three received a score of 9 [23,32,35], one received a score of 8 [27], one received a score of 7 [37] and two received a score of 5 [26,38], the quality assessment are shown in Appendix S2. Therefore, no article from the meta-analysis was excluded for quality reasons.…”

Section: Resultsmentioning

confidence: 99%

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Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Yang

Chai

Meng

2023

Preprint

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Background: The impact of vitamin D on type 1 diabetes has been a controversial topic in public health. Furthermore, significant differences in the proportion of vitamin D have been noted. The purpose of this systematic review was to determine the overall proportion of vitamin D deficiency in children/adolescents with type 1 diabetes (T1D). Methods: Based on six electronic databases (PubMed, Web of Science, Embase, Ovid Medline, ProQuest, and Cochrane Library), eligible studies since the databases’ inception up to April 2022 were searched. Reference lists were also manually searched to identify additional studies. Overall, studies with statistical information on vitamin D deficiency in children and adolescents with T1D were included, and a random effects model was applied for the meta-analysis. In addition, subgroup and sensitivity analyses were carried out to evaluate heterogeneity, and publication bias was evaluated by using Egger’s test. Results: A total of 45 studies involving 6,995 participants were selected for the meta-analysis. The proportion of vitamin D deficiency in children/adolescents with T1D was found to be 45% (95% confidence interval [CI] 37-54%, I2 = 97.94%). Subgroup analysis further showed that the publication year, study design, classification of vitamin D, different seasons and geographical region could significantly contribute to variations in the reported proportion of vitamin D deficiency. Conclusions: This systematic review analyzed the available literature and revealed that the proportion of vitamin D deficiency among T1D children/adolescents was 45%. In addition, the proportion remains higher, which has important implications for adapting health and social care systems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Yang

Chai

Meng

2023

Preprint

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“… 31 This was consistent with other reports in which improvements in glycemic control measured by HbA1c levels were documented but without statistical significance. 23 , 24 , 32 In a systematic meta-analysis review conducted in 2022, Nascimento et al evaluated the effect of vitamin D supplementation on HbA1c levels and reported a significant improvement in glycemic control in 50% of the analyzed studies. 33 However, there is yet to be consistent evidence on the effect of vitamin D supplementation on the glycemic control of children/adolescents with T1DM, as other studies have shown that vitamin D supplements fail to improve glycemic control.…”

Section: Discussionmentioning

confidence: 99%

Does vitamin D supplementation benefit patients with type 1 diabetes mellitus who are vitamin D deficient? A study was performed at the Sudan Childhood Diabetes Center from 2019 to 2022

Suliman,

Elkhawad,

Babiker

et al. 2024

SAGE Open Medicine

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Objectives: Type 1 diabetes mellitus is a chronic autoimmune disease caused by insufficient production of insulin. Many studies have linked type 1 diabetes mellitus to vitamin D3 deficiency. We investigated the prevalence of vitamin D deficiency in Sudanese children and adolescents with type 1 diabetes mellitus and assessed the impact of vitamin D deficiency treatment on their glycemic control. Methods: In 2019–2022, we conducted a quasi-experimental study on 115 children with type 1 diabetes mellitus (1–19 years old) at the Sudan Childhood Diabetes Center. Vitamin D supplements were given orally to deficient patients for 3 months. The concentrations of hemoglobin A1c, fasting blood glucose, insulin dosage, and vitamin D (25-hydroxyvitamin D (25(OH)D)) were measured before and after vitamin D3 administration. One-way ANOVA and paired sample t-tests were used to evaluate the effect of supplementation. Results: Only 27% of type 1 diabetes mellitus children were deficient in vitamin D, whereas 31.1% were inadequate and 40.9% were sufficient. The administration of vitamin D supplements slightly improved hemoglobin A1c levels in 67.7% of the patients, but the difference was not significant (mean 10.8 ± 2.1% before, 10.1 ± 2.5% after, p0.05 = 0.199). However, there was a significant decrease in the fasting blood glucose level (mean: 174.978.5–136.759.1 ng/ml; p0.05 = 0.049). Vitamin D levels were significantly increased after treatment (mean = 49.6 ng/mL; t-test = −11.6, 95% CI 40.8–(−28.6); p0.05 = 0.000). After vitamin D3 supplementation, 25.8% of individuals changed their insulin dosage; however, there was no significant variation in insulin needs. Conclusions: The prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes mellitus in Sudan is relatively high; incorporating vitamin D supplements in their treatment plan may improve their glycemic control.

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Vitamin D and type 1 diabetes

Martens,

Gysemans,

Mathieu

2024

Feldman and Pike's Vitamin D

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Vitamin D status is related to severity at onset of diabetes and worse glycemic control

Cited by 5 publications

References 38 publications

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Does vitamin D supplementation benefit patients with type 1 diabetes mellitus who are vitamin D deficient? A study was performed at the Sudan Childhood Diabetes Center from 2019 to 2022

Vitamin D and type 1 diabetes

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