Vitamin D Status, Bone Mineral Density, and VDR Gene Polymorphism in a Cohort of Belarusian Postmenopausal Women

Marozik, Pavel; Rudenka, Alena; Kobets, Katsiaryna; Rudenka, Ema

doi:10.3390/nu13030837

Cited by 22 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degree of bile acid receptor activation is largely influenced by the GM (Jones et al, 2014). Vitamin D plays an important role in bone metabolism and the prevention of multifactorial pathologies, including osteoporosis (Marozik et al, 2021). Vitamin D and its active metabolites further participate in bone tissue mineralization, maintaining calcium homeostasis, and bone remodeling, which are mediated through the VDR (Banjabi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Qiao

Zhang²,

Li³

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundAssessing the correlation between gut microbiota (GM) and bone homeostasis has increasingly attracted research interest. Meanwhile, GM dysbiosis has been found to be associated with abnormal bone metabolism. However, the function of GM in disuse-induced osteoporosis (DIO) remains poorly understood. In our research, we evaluated the characteristics of GM and fecal metabolomics to explore their potential correlations with DIO pathogenesis.MethodsDIO rat models and controls (CON) underwent micro-CT, histological analyses, and three-point bending tests; subsequently, bone microstructures and strength were observed. ELISAs were applied for the measurement of the biochemical markers of bone turnover while GM abundance was observed using 16S rDNA sequencing. Metabolomic analyses were used to analyze alterations fecal metabolites. The potential correlations between GM, metabolites, and bone loss were then assessed.ResultsIn the DIO group, the abundance of GM was significantly altered compared to that in the CON group. Moreover, DIO significantly altered fecal metabolites. More specifically, an abnormally active pathway associated with bile acid metabolism, as well as differential bacterial genera related to bone/tissue volume (BV/TV), were identified. Lithocholic acid, which is the main secondary bile acid produced by intestinal bacteria, was then found to have a relationship with multiple differential bacterial genera. Alterations in the intestinal flora and metabolites in feces, therefore, may be responsible for DIO-induced bone loss.ConclusionsThe results indicated that changes in the abundance of GM abundance and fecal metabolites were correlated with DIO-induced bone loss, which might provide new insights into the DIO pathogenesis. The detailed regulatory role of GM and metabolites in DIO-induced bone loss needs to be explored further.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Qiao

Zhang²,

Li³

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Importantly, such gene polymorphisms affect VDR expression and function, thereby influencing the risk of developing osteoporosis [ 14 ]. The VDR FokI variant is located in exon 2 of the VDR gene; this causes the loss of the ATG translation initiation region, resulting in a shorter and more active VDR protein, which plays a crucial role in message stability and posttranscriptional processes [ 15 , 16 ]. In 2006, Zintzaras et al [ 17 ] performed a meta-analysis on the correlation between VDR gene polymorphisms and osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Decisive gene strategy on osteoporosis: a comprehensive whole-literature-based approach for conclusive candidate gene targets

Chen

Tsai

Wang

et al. 2022

Aging

View full text Add to dashboard Cite

Purpose: Previous meta-analyses only examined the association between single gene polymorphisms and osteoporosis; there is no compilation of all gene loci that correlate with osteoporosis in the literature. In this study, we develop a new literature-based approach, a decisive gene strategy (DGS), to examine the sufficiency of the cumulative sample size for each gene locus and to assess whether a definite conclusion of the association between the gene locus and osteoporosis can be drawn. Methods: The DGS was used to search PubMed, Embase, and Cochrane databases for all meta-analyses that correlated gene polymorphisms with osteoporosis. Trial sequential analysis was employed to examine the sufficiency of the cumulative sample size. Finally, we assessed the importance of gene loci in osteoporosis based on whether there were enough sample sizes and the heterogeneity of the literature with the I 2 value. Results: After excluding 169 irrelevant publications, 39 meta-analysis papers were obtained. Among Caucasians, in 17 gene loci, there were eight gene loci (e.g., vitamin D Receptor ApaI rs7975232) with sufficient cumulative sample size to confirm that they were unrelated to the disease. Among Asians, in 15 gene loci, four gene loci that had sufficient sample sizes were risk factors: VDR FokI rs2228570 (odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.22–1.70), TGF β1 rs1800470 (OR = 1.35, 95% CI = 1.10–1.65), IGF1 rs2288377 (OR = 1.44, 95% CI = 1.28–1.62), and IGF1 rs35767 (OR = 1.20, 95% CI = 1.06–1.36), respectively, whereas one gene locus, ESR2 RsaI rs1256049 (OR = 0.69, 95% CI = 0.59–0.81), was a protective factor. Conclusions: The DGS successfully identified five gene loci in osteoporosis that will apply to other diseases to find causal genes, which may contribute to further genetic therapy.

show abstract

“…A significant dose effect of 25 (OH) D was found for the rs1544410, rs731236, and rs11568820 genotypes. 25 (OH) D deficiency has been associated with the rs731236 A / A polymorphism [60]. Carriage of the homozigous genotype TT rs2228570 gene and the homozigous genotype CC rs731236 of the VDR was associated with the presence of osteopenia and decreased BMD along with impaired vitamin D function in young healthy women in Saudi Arabia [61].…”

Section: Association Of the Vdr Ggene's Snvs With The Development Of Osteoporosismentioning

confidence: 98%

Perspectives of personalized approach to prevention and treatment of anticonvulsant-induced osteoporosis via action on vitamin D exchange and VDR expression

Dontseva

Trefilova²,

Попова³

et al. 2021

jour

View full text Add to dashboard Cite

Anticonvulsant-induced osteoporosis (AIO) and associated pain syndromes and patient disabilities are an important interdisciplinary medical problem generated by various molecular, genetic and pathophysiological mechanisms. AIO are the most important pathological processes associated with chronic pain in adults with epilepsy. Standard approaches to their prevention and treatment do not always solve the problem of the progression of the pathological process and chronicity of AIO. This is the reason for the search for new personalized strategies for the prevention and treatment of AIO. Vitamin D metabolism, expression and specificity of vitamin D receptors (VDRs) may play a key role in the development of AIO and chronic back pain in patients with epilepsy. The aim of the study was to review publications on changes in the vitamin D system in patients with AIO. We searched for articles published in e-Library, PubMed, Oxford Press, Clinical Case, Springer, Elsevier, and Google Scholar. The search was carried out by key-words and their combinations. The role of vitamin D and VDR in the development of AIO and the chronicity of back pain has been demonstrated mainly in animal models and humans. Associative genetic studies have shown that single nucleotide variants (SNVs) of the VDR gene encoding VDR may be associated with the development of osteoporosis of the spine (including those associated with the intake of an anticonvulsants). The prospects for the use of vitamin D preparations for modulating the effect of anticonvulsants used to treat epilepsy are discussed. Genetic association studies of VDR gene SNVs are important for understanding the genetic predictors of AIO and chronic back pain in patients with epilepsy, as well as for developing new personalized pharmacotherapy strategies.

show abstract

Vitamin D Status, Bone Mineral Density, and VDR Gene Polymorphism in a Cohort of Belarusian Postmenopausal Women

Cited by 22 publications

References 37 publications

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Decisive gene strategy on osteoporosis: a comprehensive whole-literature-based approach for conclusive candidate gene targets

Perspectives of personalized approach to prevention and treatment of anticonvulsant-induced osteoporosis via action on vitamin D exchange and VDR expression

Contact Info

Product

Resources

About